Cardiovascular Effect of Diosgenin in Ovariectomized Rats

Morais, Ilmara Cecilia Pinheiro de Silva; Moura, Iris Jordaˆnia Luz; Sabino, Carla Kelly Barroso; Nicolau, Lucas A.D.; Souza, Fabiana de Moura e; Silva-Filho, José Couras; Oliveira, Rita de Ca ́ssia Meneses; Medeiros, Jand Venes R.; Lima, Sidney Gonçalo de; Oliveira, Aldeídia Pereira de

doi:10.1089/jmf.2018.0019

Cited by 9 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study, OVX rats treated 28‐days with diosgenin (50 mg/kg, p.o.) significantly reduced the malondialdehyde concentration, and increased glutathione, superoxide dismutase, and nitric oxide (De Silva Morais et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

et al. 2021

View full text Add to dashboard Cite

This study evaluates the modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum-graecum L. (PE-TFG) seed extract in ovariectomized rats.The HPTLC method was used for standardization and to quantify the diosgenin in PE-TFG. For testing PE-TFG in rats, the total duration of treatment was 12-weeks, and the rats were sacrificed on week 12. The tissue samples such as blood, liver, heart, and aorta were isolated for testing inflammatory markers such as adiponectin, leptin, PPARγ, TNFα, lipid profile, hepatic markers, antioxidants, and oxidative stress markers. The PE-TFG treatment decreased the elevation of total cholesterol, triglyceride, AST, and ALT. Upon PE-TFG treatment, there was a significant increase in adiponectin and PPARγ mRNA expression. Leptin and TNFα were normal after treatment with PE-TFG seed extract. Further, micro-steatosis of hepatocytes marked glomerular hypertrophy in the kidney and increased thickness of tunica intima and media of common carotid artery was reversed after treatment with PE-TFG. Practical applicationsTrigonella foenum-graecum L. is a curative plant used to treat inflammatory conditions like diabetes, obesity, dyslipidemia, arthritis, cancer, and digestive disorders. In our study, PE-TFG supplementation has a protective effect on OVX-induced inflammation, oxidative stress, mRNA expression of adiponectin and PPARγ, hepatic steatosis, and decreased thickness of tunica intima and media of common carotid artery.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…After 1 week of adaptive feeding, the rats were anesthetized in a gas anesthesia machine containing isoflurane. The SD rats then underwent bilateral oophorectomy . Specifically, at the beginning of the operation, the hair in the surgical area of the rat’s bilateral lower back was removed.…”

Section: Methodsmentioning

confidence: 99%

“…The SD rats then underwent bilateral oophorectomy. 27 Specifically, at the beginning of the operation, the hair in the surgical area of the rat's bilateral lower back was removed. After disinfection with iodophor, the skin and muscle tissue of the rat were incised longitudinally on both sides of the spine to expose the abdominal cavity.…”

Section: In Vitro and In Vivo Biosafety Evaluationmentioning

confidence: 99%

Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway

Zhu

Jia

Yang

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

In this study, biomimetic porous magnesium alloy scaffolds were prepared to repair femoral bone defects in ovariectomized osteoporotic rats. The purpose of the study was to investigate the effect of biomimetic porous magnesium alloy scaffolds on repairing osteoporotic bone defects and possible mechanisms. The animal model of osteoporosis was established in female SD rats. Three months later, a bone defect of 3 mm in diameter and 3 mm in depth was created in the lateral condyle of the right femur. The rats were then randomly divided into two groups: an experimental group and a control group. Four weeks after surgery, gross specimens were observed and micro-CT scans were performed. The repair of osteoporotic femoral defects in rats was studied histologically using HE staining, Masson staining, and Goldner staining. The expression of Wnt5a, β-catenin, and BMP-2 was measured between groups by immunohistochemical staining. The bone defect was repaired better after the application of biomimetic porous magnesium alloy scaffolds. Immunohistochemical results showed significantly higher expression of Wnt5a, β-catenin, and BMP-2. To conclude, the biomimetic porous magnesium alloy scaffolds proposed in this paper might promote the repair of osteoporotic femoral bone defects in rats possibly through activating the Wnt/β-catenin signaling pathway.

show abstract

“…In addition, Chinese yam polysaccharides also have anti-hyperlipidemic activity and can significantly reduce LDL and TC levels [ 96 ]. Dioscin, diosgenin and pseudoprotodioscin are phytoestrogens that are structurally similar to estrogens, with antioxidant, anti-inflammatory, anti-adipogenic, and inhibitory effects on atherosclerosis associated with estrogen deficiency [ 97 , 98 , 110 ]. Dioscin was found to not only regulate lipid metabolic homeostasis, but also attenuate postmenopausal atherosclerosis in HFD and ovariectomy (HFD-OVX)-induced low-density lipoprotein receptor-deficient (LDLR-/-) mice by inhibiting oxidative stress, inflammation, and apoptosis in part dependent on the peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α)/estrogen receptor alpha (Erα) pathway [ 98 ].…”

Section: Prevention and Treatment Of Metabolic Diseasesmentioning

confidence: 99%

Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases

et al. 2023

View full text Add to dashboard Cite

Dioscorea spp. belongs to the Dioscoreaceae family, known as “yams”, and contains approximately 600 species with a wide distribution. It is a major food source for millions of people in tropical and subtropical regions. Dioscorea has great medicinal and therapeutic capabilities and is a potential source of bioactive substances for the prevention and treatment of many diseases. In recent years, increasing attention has been paid to the phytochemicals of Dioscorea, such as steroidal saponins, polyphenols, allantoin, and, in particular, polysaccharides and diosgenin. These bioactive compounds possess anti-inflammatory activity and are protective against a variety of inflammatory diseases, such as enteritis, arthritis, dermatitis, acute pancreatitis, and neuroinflammation. In addition, they play an important role in the prevention and treatment of metabolic diseases, including obesity, dyslipidemia, diabetes, and non-alcoholic fatty liver disease. Their mechanisms of action are related to the modulation of a number of key signaling pathways and molecular targets. This review mainly summarizes recent studies on the bioactive compounds of Dioscorea and its treatment of inflammatory and metabolic diseases, and highlights the underlying molecular mechanisms. In conclusion, Dioscorea is a promising source of bioactive components and has the potential to develop novel natural bioactive compounds for the prevention and treatment of inflammatory and metabolic diseases.

show abstract

Cardiovascular Effect of Diosgenin in Ovariectomized Rats

Cited by 9 publications

References 22 publications

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway

Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases

Contact Info

Product

Resources

About