:
Increased applications of pesticides mainly in agriculture and public health has resulted in increased chances of
human exposure to pesticides. Chronic exposure to pesticides has been implicated in several human diseases including
cardiovascular diseases. Cardiovascular diseases are broadly used for various heart pathological conditions including
defect blood vessels, and they include myocardial infarction, atherosclerosis, stroke, cardiomyopathy, coronary heart
disease etc. In this review, the association between human exposure to pesticides and development of cardiovascular
diseases was discussed using epidemiological and laboratory data. The toxicokinetics of pesticides in humans was
reviewed, as well as the risk factors for cardiovascular diseases. The important role of oxidative stress, and principally the
induction of reactive oxygen species as the signaling molecules for various signaling pathways involved in pesticidesinduced cardiovascular disease was discussed.