Cardiovascular diseases: Traditional and non-traditional risk factors

Shaima, Chittakath; Moorthi, Puthamohan Vinayaga; Shaheen, Naser Kutty

doi:10.5455/jmas.228597

Cited by 17 publications

(8 citation statements)

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“…Atherogenic dyslipidemia is one of the well-documented risk factors for CHD ( Shaima et al, 2016 ; Peters et al, 2016 ). Conventional lipid markers fail to distinguish between the size, density, concentration, or composition of lipoprotein particles, which may have contrasting effects on CHD risk ( Holmes et al, 2018 ; Würtz et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

et al. 2021

eLife

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Adherence to healthy lifestyles is associated with reduced risk of coronary heart disease (CHD), but uncertainty persists about the underlying lipid pathway. In a case–control study of 4681 participants nested in the prospective China Kadoorie Biobank, 61 lipidomic markers in baseline plasma were measured by targeted nuclear magnetic resonance spectroscopy. Baseline lifestyles included smoking, alcohol consumption, dietary habit, physical activity, and adiposity levels. Genetic instrument was used to mimic the lipid-lowering effect of statins. We found that 35 lipid metabolites showed statistically significant mediation effects in the pathway from healthy lifestyles to CHD reduction, including very low-density lipoprotein (VLDL) particles and their cholesterol, large-sized high-density lipoprotein (HDL) particle and its cholesterol, and triglyceride in almost all lipoprotein subfractions. The statins genetic score was associated with reduced intermediate- and low-density lipoprotein, but weak or no association with VLDL and HDL. Lifestyle interventions and statins may improve different components of the lipid profile.

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Section: Introductionmentioning

confidence: 99%

Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

et al. 2021

eLife

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“…The elevation of total cholesterol, triglyceride, or both, or a low HDL-C level called as dyslipidemia contributes to the development of atherosclerosis. High LDL cholesterol, low HDL cholesterol, high blood pressure, family history, diabetes mellitus, smoking, being postmenopausal for women and being older than 45, and obesity for men are traditional risk factors of CHD [7]. Dyslipidemia is a major risk factor for CHD.…”

Section: Examination Of Serum Lipid Profilementioning

confidence: 99%

“…Those cannot be controlled such as age, sex, family history, and race. The multiple interrelated factors seem responsible for occurrence of CHD [6], [7].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Endothelial Nitric Oxide Synthase with Dyslipidemia in Coronary Heart Disease

Darwin¹,

Elfi²,

Decroli³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Dyslipidemia is a medical condition that refers to an abnormal of blood lipids level, most common is hyperlipidemia. Elevation of blood lipid such as cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, or a low high-density lipoprotein (HDL) cholesterol level induces disturbance of endothelial function. Endothelial dysfunction in dyslipidemia is in large part due to a reduced bioavailability of nitric oxide (NO) which is synthesized by endothelial NO synthase (eNOS) which will trigger the development of atherosclerosis, and increases the risk of coronary heart disease (CHD). AIM: This study aims to determine the relationship of lipid profiles of dyslipidemia with eNOS levels in CHD patients. MATERIALS AND METHODS: This study design was a cross-sectional study. The sample in this study was 26 patients which diagnosed as CHD of outpatients in the department of cardiology of a regional general hospital and fulfilled the inclusion and exclusion criteria. Fifteen healthy individuals who come for the general check-up were included as a control group. Blood samples were collected for measurements of eNOS levels and lipid profiles that carried out according to laboratory standards. Statistical analyses were conducted using analysis of variance and Shapiro–Wilk test. RESULTS: The results of this study showed that eNOS levels in the group of CHD patients (24.174 ± 7.136 ng/ml) were significantly lower (p < 0.05) than those in the control group (72.092 ± 30.065 ng/ml). The mean of triglycerides and HDL levels has a weak correlation with the level of eNOS (p > 0.05). The mean of LDL level has moderately positive correlation with eNOS, while cholesterol has a moderate negative correlation with the level of eNOS (p > 0.05). CONCLUSION: This study concluded that high cholesterol levels and low HDL levels in dyslipidemia condition were correlated with eNOS, which has a protective function in CHD.

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“…and Cardiomyopathy (Lopez et al 2020). Hypertension, Physical inactivity, Smoking, High LDL or Low HDL cholesterol levels and High Blood Pressure are common risk factors of CVDs (Shaima et al 2016).…”

Section: Introductionmentioning

confidence: 99%

High-performance Cardiovascular Medicine: Artificial Intelligence for Coronary Artery Disease

Herath¹,

Karunasena²,

Priyankara³

et al. 2021

Preprint

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Cardiovascular disease (CVD) is identified as the leading cause of death globally, according to the World Health Organization (WHO). Approximately 17.9 million people are dying due to cardiovascular disease, which is an estimation of 31% of all deaths worldwide. CVDs are generally affecting the heart and blood vessels in the human body. Since healthcare is an essential factor for a country and its economy, researchers are looking for solutions to predict disease before getting into serious problems. This research introduces a method to development of an algorithm to predict coronary artery disease based on artificial intelligence. The algorithm was tested with 72 random subjects, which covered 11 attributes such as age, gender, height, weight, systolic and diastolic blood pressure, cholesterol, glucose, smoking, alcohol intake, and physical activities. According to the results, the prediction accuracy of the system was 81.62% at 0.879 precision.

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Cardiovascular diseases: Traditional and non-traditional risk factors

Cited by 17 publications

References 0 publications

Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

The Relationship between Endothelial Nitric Oxide Synthase with Dyslipidemia in Coronary Heart Disease

High-performance Cardiovascular Medicine: Artificial Intelligence for Coronary Artery Disease

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