Cardiovascular diseases and related risk factors accelerated cognitive deterioration in patients with late-life depression: a one-year prospective study

Zhong, Xiaomei; Wu, Zhi‐Ying; Ouyang, Cong; Liang, Wanyuan; Chen, Ben; Qi, Peng; Mai, Naikeng; Wu, Yuejie; Chen, Xinru; Zhang, Min; Ning, Yuping

doi:10.1017/s1041610218002041

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…There are some studies that have showed that the presence of particular aspects, or some diseases, in hypertensive population confers a greater risk of cognitive impairment. This is the case of hypertensive patients with depression (49,50), or hypertensive population with a worse economic situation (51). In general population, many others factors such as depression, educational level, socioeconomic status (rural areas, low income, less social participation), physical inactivity or unhealthy diet have also been related to the development of cognitive impairment (3,(52)(53)(54)(55).…”

Section: Other Factors Related To High Bp and Risk Of Developing Cognmentioning

confidence: 99%

Hypertension and the Risk of Dementia

Sierra

2020

Front. Cardiovasc. Med.

115

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Hypertension, particularly midlife high blood pressure, has been related to a higher risk of cognitive decline and dementia, including Alzheimer disease. However, these associations are complex and not fully elucidated. Cerebral small vessel disease emerges as one of the most important causes. Several observational studies have shown the potential beneficial role of antihypertensive treatment in preventing cognitive decline. However, randomized clinical trials (RCTs) have shown controversial results without proving nor disproving the association. On the other hand, in very elderly or frail people some studies have observed a relationship between low blood pressure and worse cognitive function. The optimal systolic and diastolic blood pressure values for protecting cognitive function, especially in elderly people, are not known.

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Section: Other Factors Related To High Bp and Risk Of Developing Cognmentioning

confidence: 99%

Hypertension and the Risk of Dementia

Sierra

2020

Front. Cardiovasc. Med.

115

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Independent and joint associations of cardiometabolic multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic

Zhao,

Xu,

Yan

et al. 2024

The Lancet Regional Health - Western Pacific

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Risk factors for cognitive dysfunction amongst patients with cardiovascular diseases

Pal,

Iantovics,

Preg

et al. 2024

Front. Public Health

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BackgroundThe impact of cardiovascular diseases on cognition raises important research questions. The study aimed to investigate the relationship between demographic data, cardiovascular diseases, kidney disease and depressive symptoms on cognition.MethodsA cross-sectional study of patients with cardiovascular diseases was performed. The Montreal Cognitive Assessment (MoCA) was applied for cognitive evaluation. Based on MoCA three groups were defined: preserved cognition, mild, and advanced cognitive dysfunction (CD). Data were analyzed using Cronbach alpha (Cα) and McDonald’s ω (Mω) for internal consistency. The Chi-square test, Cramer’s V test, and correlation analyses were also applied.ResultsOf 628 patients, 55.2% had mild CD, and the mean age was 67.95 (SD 9.53) years. Cα and Mω were 0.7, indicating good internal consistency. We found a moderate positive correlation between depression and the severity of CD (r = 0.25, p = 0.0001). A weak association between CD and female gender (p = 0.016), atrial fibrillation (p = 0.03), stroke (p = 0.009), and a moderate association for age group (p < 0.0001), education level (p < 0.0001), smoking (p < 0.0001), and renal dysfunction (p < 0.0001) was found. Age ≥ 70 years, eGFR 30–59 mL/min/1.73m2 significantly increased the likelihood for mild and advanced CD, while smoking and > 9 classes decreased it. Female gender, history of atrial fibrillation, and stroke significantly increased the likelihood of advanced CD.ConclusionMild CD was the most common in patients with cardiovascular diseases. Older age, lower education, being a non-smoker, and renal dysfunction were risk factors for both mild and advanced CD. Female gender, previous diagnosis of atrial fibrillation, and stroke are risk factors for advanced CD.

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Cardiovascular diseases and related risk factors accelerated cognitive deterioration in patients with late-life depression: a one-year prospective study

Cited by 3 publications

References 35 publications

Hypertension and the Risk of Dementia

Hypertension and the Risk of Dementia

Independent and joint associations of cardiometabolic multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic

Risk factors for cognitive dysfunction amongst patients with cardiovascular diseases

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