Cardiovascular Diseases and Periodontitis

Hansen, Peter Riis; Holmstrup, Palle

doi:10.1007/978-3-030-96881-6_14

Cited by 20 publications

(13 citation statements)

References 137 publications

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“…Patients of course need to brush and floss, but, even when used regularly and well, these tools are insufficient to manage periodontitis or advanced gingivitis, as is evident in the high rates of periodontal disease. Improving periodontal health will also provide protection from other diseases such as cardiovascular disease and diabetes [23]. Adding prescription tray delivery of the antimicrobial hydrogen peroxide is an excellent choice in the post-antibiotic age.…”

Section: Discussionmentioning

confidence: 99%

Oral Care in A Post-Antibiotic Age: Problems and Treatment Options

Dunlap¹

2022

OJDOH

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Antibiotic overuse has created a problem with increased antibiotic resistance of disease-causing microorganisms. Prophylactic antibiotic usage in dentistry has contributed to this problem and to adverse events like Clostridioides difficile infection. Antibiotic prescribing practices need review, and so do treatment options for patient care in the post-antibiotic age. Hydrogen peroxide is an example of an antimicrobial that can treat anaerobic organisms and those found in biofilms to reduce periodontal disease and improve general health. The development and use of non-antibiotic, broadspectrum antimicrobial and anti-inflammatory agents and narrowly targeted antibiotic prescription usage will improve dentistry.

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Section: Discussionmentioning

confidence: 99%

Oral Care in A Post-Antibiotic Age: Problems and Treatment Options

Dunlap¹

2022

OJDOH

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“…Intensive periodontitis treatment, consisting of oral hygiene education, scaling, and root planing, has been suggested to improve endothelial function by the vast majority of trials. Potential biomarkers linking periodontitis with endothelial dysfunction, including C-reactive protein (CRP), interleukin (IL)-1, ICAM-1, E-selectin, vWF, plasminogen activator inhibitor type-1 (PAT-1), and plasminogen, have been found to be decreased after periodontal treatment (Tonetti et al, 2007;Li et al, 2011b;D'Aiuto et al, 2013;Hansen and Holmstrup, 2022). More than 10 years ago, Tonetti et al (2007) showed that improved endothelial function paralleled periodontal health 60 and 120 days after periodontal therapy, although ED and an increase in inflammatory factors were observed 24 h after periodontal treatment.…”

Section: The Effect Of Periodontal Therapy On Vascular Endothelial Fu...mentioning

confidence: 99%

The impact of periodontitis on vascular endothelial dysfunction

Ouyang

2022

Front. Cell. Infect. Microbiol.

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Periodontitis, an oral inflammatory disease, originates from periodontal microbiota dysbiosis which is associated with the dysregulation of host immunoinflammatory response. This chronic infection is not only harmful to oral health but is also a risk factor for the onset and progress of various vascular diseases, such as hypertension, atherosclerosis, and coronary arterial disease. Vascular endothelial dysfunction is the initial key pathological feature of vascular diseases. Clarifying the association between periodontitis and vascular endothelial dysfunction is undoubtedly a key breakthrough for understanding the potential relationship between periodontitis and vascular diseases. However, there is currently a lack of an updated review of their relationship. Therefore, we aim to focus on the implications of periodontitis in vascular endothelial dysfunction in this review.

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“…For example, in the study of Orilisi and coworkers ( Orilisi et al, 2021 ) it was shown that patients with oral health problems were referred to intensive care more often than those without. The pathomechanism here involved is the chronic oral infection that upregulates many cytokines and inflammatory mediators with subsequent systemic organ effects ( Hansen and Holmstrup, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Periodontitis may predict the use of prescription medicines later in life, a database study

et al. 2023

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Medications used for the treatment of diseases also affect oral health. We investigated how having/not having periodontitis at baseline in 1985 was associated with purchases of medicines in the long term. The study paradigm is in the oral health-systemic health connections. We hypothesized that periodontitis links to purchases of medicines later in life. The study cohort consisted of 3,276 individuals from the greater Stockholm area, Sweden. Of them, 1,655 were clinically examined at baseline. Patients were followed-up for >35 years, using the national population and patient registers. The burden of systemic diseases and purchases of medicines were statistically analyzed comparing patients with (n = 285) and without (n = 1,370) periodontitis. The results showed that patients with periodontitis had purchased more of certain medications than non-periodontitis patients. Periodontitis patients purchased significantly more drugs used in diabetes (p = 0.035), calcium channel blockers (p = 0.016), drugs acting on the renin-angiotensin system (p = 0.024), and nervous system drugs (p = 0.001). Hence, patients with periodontitis indeed had purchased specific medications statistically significantly more than the periodontally healthy ones. This indicates that periodontitis, over time, might increase the risk for systemic diseases with the subsequent need for medication.

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Cardiovascular Diseases and Periodontitis

Cited by 20 publications

References 137 publications

Oral Care in A Post-Antibiotic Age: Problems and Treatment Options

Oral Care in A Post-Antibiotic Age: Problems and Treatment Options

The impact of periodontitis on vascular endothelial dysfunction

Periodontitis may predict the use of prescription medicines later in life, a database study

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