Cardiovascular disease risk factors and glucose tolerance The Wadena City health study

Sprafka, J. Michael; Xue, Songlin; Bushhouse, Sally; French, L. R.; Martinez, Anita M.; Goetz, Frederick C.

doi:10.1016/1047-2797(92)90009-f

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…Data from population‐based studies demonstrate that impaired glucose tolerance is associated with a high prevalence of cardiovascular risk factors and increased cardiovascular mortality [7–10]. In one study, an atherogenic risk profile was seen to precede the development of an overtly disordered glucose metabolism [11].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and glucose levels in a population‐based sample

et al. 2004

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Section: Introductionmentioning

confidence: 99%

Oxidative stress and glucose levels in a population‐based sample

et al. 2004

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“…This limitation is especially problematic for triglyceride and cholesterol valuesÐthe association between diabetes and dyslipidemia is well recognized; elevated triglycerides and LDL to HDL cholesterol ratios are associated with increased risk of CVD among persons with diabetes; 17,18 and a few studies have reported between-sex differences in these factors and their associated risks. 15,19,20 The extent to which comparisons between the sexes and over time in the present study were confounded by differences in unmeasured risk factors is unclear. It is also not known whether diabetic women and men differed with respect to temporal trends in these unmeasured factors.…”

Section: Discussionmentioning

confidence: 80%

Loss of the female advantage with cardiovascular disease forwomen with diabetes

Leibson

1999

Lupus

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There were 1330 diabetes cases 1970- 1989. Compared to men, women at diagnosis were older and more likely hypertensive, had similar levels of fasting glucose and persistent proteinuria, and less likely to smoke. Among persons diagnosed at younger ages, women were more likely than men to be obese. Comparison with published data for the Rochester population revealed the excess obesity and hypertension associated with diabetes were highest for women < age 55 y. Temporal trends in CVD risk factors did not differ between diabetic men and women.

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Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells

Rasmussen

Park

et al. 2011

Nutrition Research

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Adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a critical role in the formation and metabolism of high-density lipoproteins (HDLs). Adenosine triphosphate-binding cassette transporter A1 in the liver and small intestine, in particular, accounts for approximately 90% of plasma HDL cholesterol. Therefore, any alterations in the hepatic and intestinal expression of ABCA1 could have a large impact on HDL biogenesis. We tested the hypothesis that ABCA1 expression is regulated differentially by different types of fatty acids in the liver and small intestine. Human hepatoma HepG2 and human small intestine epithelial FHs 74 Int cells were used as an in vitro model. Cells were incubated with saturated and unsaturated fatty acids in the presence or absence of T0901317, a synthetic agonist of liver X receptor. Unsaturated fatty acids decreased ABCA1 protein levels at 100 μmol/L of concentration regardless of the agonist with a minimal effect on messenger RNA abundance. Incubation of HepG2 and FHs 74 Int cells with rottlerin, a protein kinase C δ (PKCδ) inhibitor, increased ABCA1 protein but did not abolish linoleic acid-induced decrease in ABCA1 protein levels. Depletion of PKCδ using small interfering RNA showed decreased ABCA1 protein levels in control, palmitic acid-, and linoleic acid-treated cells, but the repressive effect of linoleic acid was sustained. In conclusion, our results indicate that unsaturated fatty acids regulate ABCA1 expression in HepG2 and FHs 74 Int cells at the posttranscriptional level, and PKCδ is likely to be involved in maintaining ABCA1 protein levels.

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Cardiovascular disease risk factors and glucose tolerance The Wadena City health study

Cited by 5 publications

References 36 publications

Oxidative stress and glucose levels in a population‐based sample

Oxidative stress and glucose levels in a population‐based sample

Loss of the female advantage with cardiovascular disease forwomen with diabetes

Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells

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