Cardiovascular Disease-Related Serum Proteins in Workers Occupationally Exposed to Polycyclic Aromatic Hydrocarbons

Alhamdow, Ayman; Lindh, Christian; Albin, María; Gustavsson, Per; Tinnerberg, Håkan; Broberg, Karin

doi:10.1093/toxsci/kfz142

Cited by 22 publications

(13 citation statements)

References 62 publications

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“…Similarly, chimney sweeps, who are occupationally exposed to particulate matter and PAHs, were reported to have CVD-related proteins [protein-glutamine gamma-glutamyltransferase 2 (TGM2), glyoxalase I (GLO1), NF-kappa-B essential modulator (NEMO), follistatin (FS), prointerleukin-16 (IL-16), and heat shock protein beta-1 (HSP 27)] in their sera. These serum protein markers also showed a positive association with the monohydroxylated metabolites of PAHs ( 173 ). Some of these proteins were correlated with homocysteine and cholesterol.…”

Section: Developments In the Fieldmentioning

confidence: 99%

“…Exposure to PAHs also may have induced oxidative stress in chimney sweeps, which could lead to endothelial dysfunction and inflammation resulting in atherosclerosis and hypertension (175). The increased expression of GLO1, NEMO, FS, and HSP 27 in chimney sweeps could be a compensatory response against PAH-induced oxidative damage (173).…”

Section: Relevance Of Proteomics In Chemical Exposure-induced Cvdmentioning

confidence: 99%

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Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Juárez

Hood

Song

et al. 2020

Front. Public Health

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Obesity, diabetes, and hypertension have increased by epidemic proportions in recent years among African Americans in comparison to Whites resulting in significant adverse cardiovascular disease (CVD) disparities. Today, African Americans are 30% more likely to die of heart disease than Whites and twice as likely to have a stroke. The causes of these disparities are not yet well-understood. Improved methods for identifying underlying risk factors is a critical first step toward reducing Black:White CVD disparities. This article will focus on environmental exposures in the external environment and how they can lead to changes at the cellular, molecular, and organ level to increase the personal risk for CVD and lead to population level CVD racial disparities. The external environment is defined in three broad domains: natural (air, water, land), built (places you live, work, and play) and social (social, demographic, economic, and political). We will describe how environmental exposures in the natural, built, and social environments "get under the skin" to affect gene expression though epigenetic, pan-omics, and related mechanisms that lead to increased risk for adverse CVD health outcomes and population level disparities. We also will examine the important role of metabolomics, proteomics, transcriptomics, genomics, and epigenomics in understanding how exposures in the natural, built, and social environments lead to CVD disparities with implications for clinical, public health, and policy interventions. In this review, we apply an exposome approach to Black:White CVD racial disparities. The exposome is a measure of all the exposures of an individual across the life course and the relationship of those exposures to health effects. The exposome represents the totality of exogenous (external) and endogenous (internal) exposures from conception onwards, simultaneously distinguishing, characterizing, and quantifying etiologic, mediating, moderating, and co-occurring risk and protective factors and their relationship to disease. Specifically, it assesses the biological mechanisms and underlying pathways through which chemical and non-chemical environmental Juarez et al. The Exposome and Cardiovascular Disease exposures are associated with CVD onset, progression and outcomes. The exposome is a promising approach for understanding the complex relationships among environment, behavior, biology, genetics, and disease phenotypes that underlie population level, Black: White CVD disparities.

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Section: Developments In the Fieldmentioning

confidence: 99%

Section: Relevance Of Proteomics In Chemical Exposure-induced Cvdmentioning

confidence: 99%

Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Juárez

Hood

Song

et al. 2020

Front. Public Health

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“…PEA has been successfully used to detect plasma biomarkers for cancer and cardiovascular diseases. [26][27][28] According to both manufacturers, more than 80% of the assays are expected to detect proteins on ethylenediaminetetraacetic acid-treated plasma from healthy donors. In our study, using the PEA platform, 79.7% of the assays were able to detect proteins in at least 25% of the vitreous samples, whereas only 41.5% of the ECL assays detected proteins in more than 25% of the vitreous samples.…”

Section: Discussionmentioning

confidence: 99%

“…PEA has been successfully used to detect plasma biomarkers for cancer and cardiovascular diseases. 26 – 28 …”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Multiplex Platforms for Detecting Vitreous Biomarkers in Diabetic Retinopathy

Lamy

Farber-Katz

Vives

et al. 2020

Trans. Vis. Sci. Tech.

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To evaluate the feasibility of using the Proximity Extension Assay (PEA) platform to detect biomarkers in vitreous and to compare the findings with results obtained with an electrochemiluminescent (ECL) sandwich immunoassay. Methods: Vitreous samples from patients with proliferative diabetic retinopathy (PDR) and non-diabetic controls were tested using two different proteomics platforms. Fortyone assays were completed with the ECL platform and 459 with the PEA platform. Spearman's rank correlation coefficient (r s) was used to determine the direction and strength of the relationship between protein levels detected by both platforms. Results: Three hundred sixty-six PEA assays detected the tested protein in at least 25% of samples, and the difference in protein abundance between PDR and controls was statistically significant for 262 assays. Seventeen ECL assays yielded a detection rate ≥ 25%, and the difference in protein concentration between PDR and controls was statistically significant for 13 proteins. There was a subset of proteins that were detected by both platforms, and for those the Spearman's correlation coefficient was higher than 0.8. Conclusions: PEA is suitable for the analysis of vitreous samples, showing a strong correlation with the ECL platform. The detection rate of PEA panels was higher than the panels tested with ECL. The levels of several proinflammatory and angiogenic cytokines were significantly higher in PDR vitreous compared to controls. Translational Relevance: This study provides new information on the yields of smallvolume assays that can detect proteins of interest in ocular specimens, and it identifies patterns of cytokine dysregulation in PDR.

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“…In another study, the authors found that PAH exposure was associated with levels of putative cardiovascular disease-related proteins in serum. The findings show that differentially expressed proteins are mainly involved in inflammatory response and immunological functions, such as leukocyte migration, leukocyte cell movement, and immune cell adhesion [38]. In addition, some PAHs metabolites also show consistent positive association with C-reactive protein, a plasma inflammation marker [39].…”

Section: Discussionmentioning

confidence: 99%

Long-term ambient hydrocarbons exposure and incidence of ischemic stroke

et al. 2019

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Exposure to air pollutants is known to have adverse effects on human health; however, little is known about the association between hydrocarbons in air and an ischemic stroke (IS) event. We investigated whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increased IS risk. This retrospective cohort study included 283,666 people aged 40 years or older in Taiwan. Cox proportional hazards regression analysis was used to fit single- and multiple-pollutant models for two targeted pollutants, total hydrocarbons (THC) and nonmethane hydrocarbons (NMHC), and estimated the risk of IS. Before controlling for multiple pollutants, hazard ratios (HRs) of IS with 95% confidence intervals for the overall population were 2.69 (2.64–2.74) at 0.16-ppm increase in THC and 1.62 (1.59–1.66) at 0.11-ppm increase in NMHC. For the multiple-pollutant models controlling for PM2.5, the adjusted HR was 3.64 (3.56–3.72) for THC and 2.21 (2.16–2.26) for NMHC. Our findings suggest that long-term exposure to THC and NMHC may be a risk factor for IS development.

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Cardiovascular Disease-Related Serum Proteins in Workers Occupationally Exposed to Polycyclic Aromatic Hydrocarbons

Cited by 22 publications

References 62 publications

Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Comparative Analysis of Multiplex Platforms for Detecting Vitreous Biomarkers in Diabetic Retinopathy

Long-term ambient hydrocarbons exposure and incidence of ischemic stroke

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