Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study

Abstract

IntroductionInflammation is an established component of cardiovascular disease (CVD) and an underlying factor of several dermatologic conditions including rosacea, atopic dermatitis, and psoriasis. Identifying potential associations between these dermatologic and cardiovascular diseases can better inform holistic healthcare approaches. The objective of this study was to determine whether rosacea, psoriasis or atopic dermatitis are independent risk factors for CVD 1 year following diagnosis.MethodsUsing a large commercial claims database of 21,801,147 lives, we employed a propensity-matched logistic regression to evaluate the association between diagnoses of rosacea, psoriasis, or atopic dermatitis and a 1-year risk of being diagnosed with cardiovascular disease. Control patients were matched based on health-care utilization, age and overall health status as defined by a modified Deyo–Charlson comorbidity index.ResultsThe analysis included 2105 rosacea, 622 atopic dermatitis, 1536 psoriasis, and 4263 control patients. Compared to propensity-matched controls, the adjusted odds of cardiovascular disease were not higher in patients with rosacea (odds ratio: 0.894, p = 0.2713), atopic dermatitis (OR 1.032, p = 0.8489), or psoriasis (OR 1.087, p = 0.4210). In univariate analysis, the unadjusted odds of cardiovascular disease was higher in patients with psoriasis (OR 1.223, p = 0.0347).ConclusionsLimitations of this study include the short follow-up period and inclusion of only commercially insured patients limit the generalizability of these findings. In this large study of patients with rosacea, atopic dermatitis, and psoriasis, we did not detect an increased 1-year risk of cardiovascular disease after adjusting for confounders.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-016-0144-3) contains supplementary material, which is available to authorized users.

The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis

“…). A total of 16 publications were included in the qualitative analysis and further details about the publications are presented online and below (Tables S1–S6; see Supporting Information) …”

“…A total of 13 studies were included in the quantitative meta‐analysis on crude data. Studies originated from Taiwan (two), Germany (one), Denmark (five), Canada (one) and the U.S.A. (four) . Two of the publications contained data from multiple cohorts ( n = 3), which were treated separately in the analyses, i.e.…”

“…A total of 16 publications were included in the qualitative analysis and further details about the publications are presented online and below (Tables S1-S6; see Supporting Information). [4][5][6][7][8][9][10][12][13][14][15][16][17][18][19][20] Meta-analysis based on crude data A total of 13 studies were included in the quantitative metaanalysis on crude data. Studies originated from Taiwan (two), 15,18 Germany (one), 6 Denmark (five), 4,9,10,12,14 Canada (one) 20 and the U.S.A. (four).…”

“…Studies originated from Taiwan (two), 15,18 Germany (one), 6 Denmark (five), 4,9,10,12,14 Canada (one) 20 and the U.S.A. (four). 5,7,8,13 Two of the publications contained data from multiple cohorts (n = 3), 5,8 which were treated separately in the analyses, i.e. all cohorts were included.…”

The Pattern of Cardiovascular Comorbidity in Patients With Severe Forms of Psoriasis: Data of Retrospective Analysis of a Hospital Cohort

“…В недавнем исследовании V. Marshall и соавт. [12] изуча-лась кардиоваскулярная смертность у пациентов с наи-более распространенными дерматологическими заболе-ваниями: 2105 больных с розацеа, 622 -с атопическим дерматитом и 4263 -с Пс в сравнении с популяцией (4263 человека -контрольная группа). Значимое повы-шение кардиоваскулярной смертности обнаружено только в группе больных Пс -относительный риск со-ставил 1,223.…”