Cardiovascular Disease in the Systemic Vasculitides

Σουλαϊδόπουλος, Στέργιος; Madenidou, Anastasia-Vasiliki; Daoussis, Dimitrios; Μελισσαρόπουλος, Κωνσταντίνος; Mavrogeni, Sophie; Kitas, George D.; Dimitroulas, Theodoros

doi:10.2174/1570161118666200130093432

Cited by 11 publications

(8 citation statements)

References 108 publications

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“…The only imaging modality to clearly depict cardiac involvement in EGPA is CMRI, [22][23][24][25][26] which was evident in our patient. CMRI has optimal spatial and temporal resolutions without any need of radiation and clearly shows the cardiac complications characteristic of the disease.…”

Section: Discussionmentioning

confidence: 74%

Cardiac Involvement and Absence of Asthma – What is Phenotype Specificity of EGPA: A Case Report

Fijołek¹,

Wiatr²,

Błasińska³

et al. 2022

Clin Med Res

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Eosinophilic granulomatosis with polyangiitis (EGPA) typically is characterized by asthma, blood eosinophilia, and extrapulmonary manifestations. Asthma is a major EGPA symptom affecting almost all patients, but cardiac involvement is one of the most serious manifestations, responsible for 31% of deaths. Two recently defined phenotypes of EGPA, according to the patient's antineutrophil cytoplasmic antibody (ANCA) status, differ significantly in clinical features and prognosis. We share a case of EGPA characterized by atypical manifestation without any evidence of asthma, in whom extensive cardiac involvement was the dominant manifestation of vasculitis. This case demonstrates the difficulties associated with phenotyping EGPA and highlights the importance of cardiac magnetic resonance imaging (CMRI) in definitive diagnosis.

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Section: Discussionmentioning

confidence: 74%

Cardiac Involvement and Absence of Asthma – What is Phenotype Specificity of EGPA: A Case Report

Fijołek¹,

Wiatr²,

Błasińska³

et al. 2022

Clin Med Res

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“…A variety of related proteins and acute phase proteins are expressed in the plasma of patients with TA, which can also be used to determine the different stages of the disease, and which are worthy of further discussion. In addition, the N-terminal pro-brain natriuretic peptide (NT pro-BNP) level was significantly higher in the PH group than the non-PH group, which may be related to the wide range of pulmonary artery lesions (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of vascular stenosis includes hormones and immunosuppressants, biological targeted therapies, percutaneous angioplasty, and surgery. Hormones, immunosuppressants and biological targeted therapies can improve the clinical symptoms of some patients; however, patients may suffer from a variety of adverse reactions to drug therapies, and it is not yet known whether such therapies can reverse the pathological structure of diseased blood vessels (24,25). In addition, the condition often repeats when the hormone dosage is reduced; thus, patients may require long-term hormone treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of pulmonary artery involvement in patients with Takayasu arteritis between pulmonary hypertension and non-pulmonary hypertension

Lei¹,

Li²,

Wang³

et al. 2023

Ann Transl Med

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Background: Multiple Takayasu arteritis (TA) is a chronic non-specific large to medium vasculitis disease that mainly accumulates the aorta and its branches. Pulmonary vascular disease is often seen as stenosis and occlusion, and patients may show no moderate to severe pulmonary hypertension. The study sought to summarize the clinical characteristics of patients with pulmonary hypertension (PH) involving the pulmonary artery caused by TA.Methods: Twenty-nine patients with TA treated at the General Hospital of Ningxia Medical University from September 2009 to December 2021 were collected. All the patients had TA involving the pulmonary artery, and were divided into the PH group (n=17 patients) and the non-PH group (n=12). The diagnoses of pulmonary Takayasu arteritis (PTA) were used the 1990 diagnostic criteria of the American Rheumatic Association and the 1996 improved Ishikawa diagnostic criteria. Computed tomography angiography (CTA) of the patients after treatment was determined, and the laboratory tests, echocardiography, pulmonary and systemic artery angiography were assessed. Results:The patients had an average age of onset of 33.5 [19-60] years. All the cases of PH were confirmed by echocardiography and it was suggested that the bilateral side easier to involve pulmonary arteries than the unilateral side, and the right side than the left side. At admission, the ESR and N pro-BNP level of the PH group did not differ significantly to those of the non-PH Group. There were significant differences between the two groups in patients in terms of the type II of TA imaging diagnosis (P=0.030). The accuracy of diagnosing PH with bilateral pulmonary vascular involvement was significantly higher in the PH group than the non-PH group (P=0.003). The diagnostic accuracy of pulmonary vascular lumen obstruction in the PH group was significant difference (P<0.05). The diagnostic accuracy of pleural effusion in the PH group was significantly higher than that of the non-PH group (P=0.001) for lung field signs. The diameters of the right atrium and pulmonary artery differed significantly between the two groups (P=0.013).Conclusions: Patients with TA involving the pulmonary artery mainly complained of shortness of breath.Most of these patients had PH.

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“…Many other mimickers also exist such as pulmonary cement embolism after kyphoplasty, and thoughtful evaluation with a multidisciplinary approach involving an experienced radiologist is paramount. Certainty of the diagnosis is crucial as taking the patient to the operating room without the correct diagnosis can lead to significant morbidity and mortality ( 6 ).…”

Section: Discussionmentioning

confidence: 99%