Cardiovascular disease in systemic lupus erythematosus: A comprehensive update

Giannelou, Mayra; Mavragani, Clio P.

doi:10.1016/j.jaut.2017.05.008

Cited by 143 publications

(97 citation statements)

References 177 publications

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“…Obesity and metabolic syndrome are associated with SLE and may contribute to a variety of SLE-associated pathologies. 79 This may occur due to increased nutrient acquisition by inflammatory cells in settings of hyperglycemia and hyperlipidemia, but may also be regulated through changes in hormones or adipokines, such as leptin. A variety of metabolic inhibitors have been tested in animal models of SLE.…”

Section: Immunome Tabolis M In Tissue Smentioning

confidence: 99%

Immunometabolism: From basic mechanisms to translation

Makowski

Chaib

Rathmell

2020

Immunological Reviews

228

190

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Immunometabolism has emerged as a major mechanism central to adaptive and innate immune regulation. From early observations that inflammatory cytokines were induced in obese adipose tissue and that these cytokines contributed to metabolic disease, it was clear that metabolism and the immunological state are inextricably linked. With a second research wave arising from studies in cancer metabolism to also study the intrinsic metabolic pathways of immune cells themselves and how those pathways influence cell fate and function, immunometabolism is a rapidly maturing area of research. Several key themes and goals drive the field. There is abundant evidence that metabolic pathways are closely tied to cell signaling and differentiation which leads different subsets of immune cells to adopt unique metabolic programs specific to their state and environment. In this way, metabolic signaling drives cell fate. It is also apparent that microenvironment greatly influences cell metabolism.Immune cells adopt programs specific for the tissues where they infiltrate and reside.Ultimately, a central goal of the field is to apply immunometabolism findings to the discovery of novel therapeutic strategies in a wide range of diseases, including cancer, autoimmunity, and metabolic syndrome. This review summarizes these facets of immunometabolism and highlights opportunities for clinical translation. K E Y W O R D S autoimmunity, immune-mediated diseases, infectious diseases, metThis article introduces a series of reviews covering Immunometabolism: From Basic Mechanisms to Translation appearing in Volume 295 of Immunological Reviews.

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Section: Immunome Tabolis M In Tissue Smentioning

confidence: 99%

Immunometabolism: From basic mechanisms to translation

Makowski

Chaib

Rathmell

2020

Immunological Reviews

228

190

View full text Add to dashboard Cite

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“…The high risk of both subclinical atherosclerosis and cardiovascular events are well established in SLE. Antiphospholipid syndrome (APS) secondary to SLE also showed an increased risk of developing cardiovascular diseases in patients [88]. For the observation of different miRNAs profiles in a subset of lupus patients who had cardiovascular events, Kay et al identified that miR-101, miR-375 and miR-125b were indicative of atherosclerosis, with a sensitivity of 86% and a specificity of 88%.…”

Section: Extracellular Rna and Organ Involvement In Slementioning

confidence: 99%

Extracellular RNA in systemic lupus erythematosus

Liu

Wang

Liu

2019

ExRNA

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Since the discovery of extracellular RNA (exRNA), it has been shown that exRNAs play a significant role as a transducer in intercellular communication and biomarkers in various diseases. Systemic lupus erythematosus (SLE) is a kind of autoimmune disease that has protean manifestations. The survival and long-term prognosis of patients with SLE has improved in these 5-10 years, while disease pathogenesis is still not clear. Many researchers found the changes in exRNA profile, and exRNAs are likely participating in the process of SLE. In this review, we summarize the current profile and function of exRNA in SLE. Circulating miRNAs, in particular, have been identified as biomarkers for SLE diagnosis. We also explore the function of lncRNA in SLE and the potential correlation with disease progression and activity. These studies show that exRNAs may take parts in the process of SLE and some of them can be used as diagnostic tool for SLE.

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“…But CVD-related morbidity of in Chinese SLE patients was lower in our study. The risk factors included oxidized low-density lipoprotein, autoantibodies against endothelial cells and phospholipids, type I interferons (IFN-I), and extracellular neutrophils [31]. SLEDAI was the predictor of CVD in our study, which may be affected by immunological regulation.…”

Section: Discussionmentioning

confidence: 73%

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

et al. 2018

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Objective To investigate cardiac manifestations and the risk factors in Han Chinese patients with systemic lupus erythematosus (SLE). Methods Seven hundred fifty SLE patients who were hospitalized at our department were recruited in the present study. The patients were divided into two groups-those with or without cardiac manifestations. Cardiac manifestations in those SLE patients, such as pericarditis, myocarditis, heart valve disease, arrhythmia, were analyzed. The risk and protective factors of cardiac diseases in patients with SLE, as well as the predictors of mortality, were assessed, respectively. Results In all 750 SLE patients, there were 339 (45.20%) patients suffered from one or more cardiac manifestations, involving pericarditis in 9.5%, myocarditis in 5.7%, heart valve disease in 15.6%, arrhythmia in 16.67%, and cardiovascular diseases (CVD) in 14%. 15.7% of SLE patients were accompanied with pulmonary arterial hypertension (PAH), of which 13.7% were mild, 1.2% were moderate, and 0.8% were severe. No significant differences were found between the two groups in age, disease duration, gender, antibody, and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The incidence of pericarditis, heart valve disease, arrhythmia, and PAH was positively correlated with age. The incidence of arrhythmia, CVD, and PAH was correlated with SLEDAI. PAH and myocarditis were the risk factors of mortality in SLE patients with disease duration ≤ 10 years (P = 0.034 and 0.001, respectively). Conclusion Cardiac involvement is common in Han Chinese SLE patients and associated with age and disease activity. PAH and myocarditis are the risk factors of mortality in SLE.

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Cardiovascular disease in systemic lupus erythematosus: A comprehensive update

Cited by 143 publications

References 177 publications

Immunometabolism: From basic mechanisms to translation

Immunometabolism: From basic mechanisms to translation

Extracellular RNA in systemic lupus erythematosus

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

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