Cardiovascular Disease Epidemiology and Risk Factors in Primary Care

Díez, José Miguel Baena; García, José Luis del Val; Pelegrina, J. Tomàs; Martínez, José Luis; Peñacoba, Raquel Martín; Tejón, Iván González; Quintana, Eva; Sajkiewicz, Monica Pomares; Boronat, Andreu Altés; Pérez, Beatriz Álvarez; Forcadell, P. Piñol; España, Mònica Rovira; Colom, Miquel

doi:10.1016/s1885-5857(06)60667-1

Cited by 19 publications

(8 citation statements)

References 23 publications

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“…It can, therefore, be considered to be representative of the performance of our specialty in clinical practice. The sociodemographic characteristics are similar to those described for the Spanish population in 2008 (8,9), and the prevalence of disease observed is also comparable to that described in the scientific literature (10). There are two findings that are especially interesting from the information obtained here.…”

Section: Discussionsupporting

confidence: 88%

Evaluation of the immediate post-operative procedure after dental intervetions. 24 hours follow up study. Epico Study

Bagán¹,

Soler-López²,

Épico-Study-Group³

2011

Med Oral

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Objectives: The purpose of this study was to make a descriptive approximation of the therapeutic management of the different dental interventions in clinical practice today, and to analyze the degree of consensus among the specialists participating in the study. Study Design: A total of 447 odontologists, stomatologists or maxillofacial surgeons from 43 Spanish provinces participated in the study. The study sample consisted of patients aged 18 years old or over attending the clinic for a dental intervention. The type of intervention carried out and treatments administered before and after the intervention were recorded. At 24 hours after the intervention, intensity of pain experienced by the patient, rescue therapy administered for pain relief, sleep affectation, the appearance of adverse events or complications of the intervention, and treatment compliance were also recorded. Results: Data corresponding to 4,194 patients were analyzed, of whom 53.2% were women (2,232). The mean age was 42.6 years (95%CI 42.2-43). The most frequent interventions corresponded to: oral surgery (66.4%), endodontics (17.3%) and periodontal treatment (4.6%). A total of 43.2% of the patients were taking some medication before the intervention: anticoagulants (2.5%), antibiotics (33%), pain relief and/or anti-inflammatory agents (23%) and other drugs (7.6%); 16.6% were receiving combined treatment with antibiotics and analgesics and/or anti-inflammatory agents before the intervention. Treatments prescribed to the patient for the 24 hours following the intervention corresponded to only one analgesic and/or anti-inflammatory in 18%, and a combination of analgesics and/or anti-inflammatories in 77.1%. Antibiotics were prescribed in 39.7%. Conclusions: Different patterns of therapeutic management by the specialists were noted depending on the type of intervention carried out. The use of analgesics and/or anti-inflammatories depended on the severity of pain expected with each intervention and the administration of antibiotics was related to the prevention of local infections.

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Section: Discussionsupporting

confidence: 88%

Evaluation of the immediate post-operative procedure after dental intervetions. 24 hours follow up study. Epico Study

Bagán¹,

Soler-López²,

Épico-Study-Group³

2011

Med Oral

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“…Simultaneously, 113 gender-and age-matched healthy volunteers (HC) were recruited from the same population and a group of 27 individuals with dyslipidemia (DL) was recruited from their primary healthcare center. Dyslipidemia diagnosis was performed according to national guidelines 19 . Exclusion criteria was the previous diagnosis of any immune-mediated condition.…”

Section: Patientsmentioning

confidence: 99%

High triglycerides and low high-density lipoprotein cholesterol lipid profile in rheumatoid arthritis: A potential link among inflammation, oxidative status, and dysfunctional high-density lipoprotein

Rodríguez‐Carrio

Alperi-López

López

et al. 2017

Journal of Clinical Lipidology

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“…Homocysteine (Hcy) is a byproduct of the methionine transmethylation process and hyperhomocysteinaemia (HHcy) has been recognized as an independent cardiovascular risk factor 1,2 . In vivo and in vitro evidence has shown that HHcy causes dyslipidaemia, 3 oxidative stress, 4 vascular smooth muscle cell (VSMC) proliferation, 5 and impairment of endothelial regeneration and function, 6 which are closely correlated with cardiovascular disease (CVD).…”

Section: Introductionmentioning

confidence: 99%

Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling

Yan

Zhang

et al. 2010

Clin Exp Pharma Physio

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1. Hyperhomocysteinaemia (HHcy) is associated with endothelial dysfunction and has been recognized as a risk factor of cardiovascular disease. The present study aimed to investigate the effect of homocysteine (Hcy) on endothelial function in vivo and in vitro, and the underlying signalling pathways. 2. The HHcy animal model was established by intragastric administration with l-methionine in rats. Plasma Hcy and nitric oxide (NO) concentration were measured by fluorescence immunoassay or nitrate reductase method, respectively. Vasorelaxation in response to acetylcholine and sodium nitroprusside were carried out on aortic rings. Human umbilical vein endothelial cells (HUVEC) were treated with indicated concentrations of Hcy in the in vitro experiments. Intracellular NO level and NO concentration in culture medium were assayed. The alterations of possible signalling proteins were detected by western blot analysis. 3. l-methionine administration induced a significant increase in plasma Hcy and decrease in plasma NO. Endothelium-dependent relaxation of aortic rings in response to acetylcholine was impaired in l-methionine-administrated rats. The in vitro study showed that Hcy reduced both intracellular and culture medium NO levels. Furthermore, Hcy decreased phosphorylation of endothelial nitric oxide synthase (eNOS) at serine-1177 and phosphorylation of Akt at serine-473. Hcy-induced dephosphorylation of eNOS at Ser-1177 was partially reversed by insulin (Akt activator) and GF109203X (PKC inhibitor). Furthermore, Hcy reduced vascular endothelial growth factor (VEGF) expression in a dose-dependent manner. 4. In conclusion, Hcy impaired endothelial function through compromised VEGF/Akt/endothelial nitric oxide synthase signalling. These findings will be beneficial for further understanding the role of Hcy in cardiovascular disease.

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Cardiovascular Disease Epidemiology and Risk Factors in Primary Care

Cited by 19 publications

References 23 publications

Evaluation of the immediate post-operative procedure after dental intervetions. 24 hours follow up study. Epico Study

Evaluation of the immediate post-operative procedure after dental intervetions. 24 hours follow up study. Epico Study

High triglycerides and low high-density lipoprotein cholesterol lipid profile in rheumatoid arthritis: A potential link among inflammation, oxidative status, and dysfunctional high-density lipoprotein

Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling

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