Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort- evaluation of risk factors and their interactions

Hallmans, Göran; Ågren, Anneli; Johansson, Gerd; Johansson, Anders; Stegmayr, Birgitta; Jansson, Jan‐Håkan; Lindahl, Bernt; Rolandsson, Olle; Söderberg, Stefan; Nilsson, Mats; Johansson, Ingegerd; Weinehall, Lars

doi:10.1080/14034950310001432

Cited by 195 publications

(196 citation statements)

References 23 publications

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“…Demographic and clinical data used in this report were collected as part of the VIP survey by trained research nurses using a protocol standardised across study centres [8]. Height and weight were measured using a calibrated wall-mounted stadiometer and scales, respectively.…”

Section: Clinical Measurementsmentioning

confidence: 99%

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

et al. 2007

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Aims/hypothesis Mutations at the gene encoding wolframin (WFS1) cause Wolfram syndrome, a rare neurological condition. Associations between single nucleotide polymorphisms (SNPs) at WFS1 and type 2 diabetes have recently been reported. Thus, our aim was to replicate those associations in a northern Swedish case-control study of type 2 diabetes. We also performed a meta-analysis of published and previously unpublished data from Sweden, Finland and France, to obtain updated summary effect estimates. Methods Four WFS1 SNPs (rs10010131, rs6446482, rs752854 and rs734312 [H611R]) were genotyped in a type 2 diabetes case-control study (n=1,296/1,412) of Swedish adults. Logistic regression was used to assess the association between each WFS1 SNP and type 2 diabetes, following adjustment for age, sex and BMI. We then performed a meta-analysis of 11 studies of type 2 diabetes, comprising up to 14,139 patients and 16,109 controls, to obtain a summary effect estimate for the WFS1 variants. Results In the northern Swedish study, the minor allele at rs752854 was associated with reduced type 2 diabetes risk [odds ratio (OR) 0.85, 95% CI 0.75-0.96, p=0.010]. Borderline statistical associations were observed for the remaining SNPs. The meta-analysis of the four independent replication studies for SNP rs10010131 and correlated variants showed evidence for statistical association (OR 0.87, ). In an updated meta-analysis of all 11 studies, strong evidence of statistical association was also observed (OR 0.89, 95% CI 0.86-0.92; p=4.9×10 −11 ). Conclusions/interpretation In this study of WFS1 variants and type 2 diabetes risk, we have replicated the previously reported associations between SNPs at this locus and the risk of type 2 diabetes.

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Section: Clinical Measurementsmentioning

confidence: 99%

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

et al. 2007

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“…The principal investigators of the Västerbotten Intervention Program (Hallmans et al, 2003) and the Womens' Health Study (Liu et al, 2002) could not accommodate our request and the reporting of TFA intake data was judged to be of inadequate quality by the principal investigators of the Atherosclerosis Risk in Communities Study (Folsom et al, 1997). The Iowa Womens' Health Study (IWHS) performed a relevant analysis on our request (Personal Communication with Dr Kim Robien) and the principal investigators of the Finnish Mobile Clinic Health Examination Survey (FMC) provided us with the results of an unpublished analysis (Personal Communication with Dr Paul Knekt).…”

Section: Resultsmentioning

confidence: 99%

Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies

et al. 2011

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The aim of this systematic review and meta-analysis was to summarize the evidence from observational studies assessing the association between intake of trans fatty acids (TFA) and the risk of coronary heart disease (CHD), with a specific emphasis on distinguishing between TFA of industrial and ruminant origin. By searching five bibliographic databases, analyses from six published and two unpublished prospective cohort studies, assessing the association of intake of TFA with fatal and/or non-fatal CHD, were identified. Four and three studies reported separate associations for intake of ruminant or industrial-TFA, respectively. The pooled relative risk estimates for comparison of extreme quintiles of total-TFA intake (corresponding to intake increments ranging from 2.8 to B10 g/day) were 1.22 (95% confidence interval: 1.08-1.38; P ¼ 0.002) for CHD events and 1.24 (1.07-1.43; P ¼ 0.003) for fatal CHD. Ruminant-TFA intake (increments ranging from 0.5 to 1.9 g/day) was not significantly associated with risk of CHD (risk ratio (RR) ¼ 0.92 (0.76-1.11); P ¼ 0.36), and neither was industrial-TFA intake, although there was a trend towards a positive association (RR ¼ 1.21 (0.97-1.50); P ¼ 0.09). In conclusion, our analysis suggests that industrial-TFA may be positively related to CHD, whereas ruminant-TFA is not, but the limited number of available studies prohibits any firm conclusions concerning whether the source of TFA is important. The null association of ruminant-TFA with CHD risk may be due to lower intake levels.

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“…Participants were 25 to 74 years of age, and they resided in the counties of Västerbotten and Norrbotten 17. The MSP cohort comprised women who attended routine mammography screenings 18. Taken together, these 3 surveys included 140 414 participants up to December 2014, which reflected participation rates of 65% to 75%.…”

Section: Methodsmentioning

confidence: 99%

Lipoprotein(a) and the Apolipoprotein B/A1 Ratio Independently Associate With Surgery for Aortic Stenosis Only in Patients With Concomitant Coronary Artery Disease

Ljungberg

Holmgren

Bergdahl

et al. 2017

JAHA

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BackgroundAortic stenosis (AS) has different clinical phenotypes, including AS with or without concomitant coronary artery disease (CAD). It is unknown whether these phenotypes share the same risk factors. In particular, lipoprotein(a) [Lp(a)] and apolipoproteins (Apo) are associated with AS, but it is unknown whether these associations differ among phenotypes. In this prospective analysis we examined the impact of Lp(a) and Apo in subgroups of patients with AS.Methods and ResultsWe identified 336 patients (mean age at survey 56.7 years, 48% female) who underwent surgery for AS after a median 10.9 years (interquartile range 9.3 years), participants in 1 of 3 large population surveys. For each patient, 2 matched referents were allocated. Lp(a) and Apo were analyzed in the baseline samples. Uni‐ and multivariable logistic regression analyses were used to estimate risks related to a 1 (ln) standard deviation increase in Lp(a) and the ratio of Apo B to Apo A1 (Apo B/A1 ratio). High levels of Lp(a) predicted surgery for AS in 203 patients with concomitant CAD (odds ratio [95% confidence intervals]) (1.29 [1.07‐1.55]), but not in 132 patients without CAD (1.04 [0.83‐1.29]) in the fully adjusted model. Similarly, a high Apo B/A1 ratio predicted surgery in patients with concomitant CAD (1.43 [1.16‐1.76]) but not in those without CAD (0.87 [0.69‐1.10]).ConclusionsHigh levels of Lp(a) and a high Apo B/A1 ratio were associated with surgery for AS in patients with concomitant CAD but not in those with isolated AS. This finding may lead to a new avenue of research for targeted risk factor interventions in this population.

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Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort- evaluation of risk factors and their interactions

Cited by 195 publications

References 23 publications

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies

Lipoprotein(a) and the Apolipoprotein B/A1 Ratio Independently Associate With Surgery for Aortic Stenosis Only in Patients With Concomitant Coronary Artery Disease

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