Cardiovascular Disease and Chronic Endodontic Infection. Is There an Association? A Systematic Review and Meta-Analysis

Koletsi, Despina; Iliadi, Anna; Tzanetakis, Giorgos N.; Vavuranakis, Manolis; Eliades, Theodore

doi:10.3390/ijerph18179111

Cited by 12 publications

(9 citation statements)

References 57 publications

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“…As a result, it was observed that the risk of CVD diagnosis in patients with chronic endodontic infection was 1.38 times those without infection. Therefore, there are indications for an identified association between chronic endodontic infection and CVD [19].…”

Section: Resultsmentioning

confidence: 99%

Evidence of the association between endodontic infections and heart diseases: a systematic review

Ribeiro¹,

Santos²,

Assunção³

et al. 2022

MedNEXT

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Introduction: In the scenario of heart diseases, especially cardiovascular diseases (CVD), there are several predictors of these diseases, including diseases related to oral health. Objective: It was to analyze through clinical studies the association of diseases of the oral cavity with cardiovascular diseases, to point out the main causes and treatments for future clinical studies. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from January 2022 to April 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: In line with the objective proposed in the present study, the results concluded that the association between chronic endodontic infection and CVD cannot be disregarded, although it is of limited quality evidence at the moment. Thus, clinical studies observed that the risk of diagnosing CVD in patients with chronic endodontic infection was 1.38 times those without infection. Furthermore, early childhood caries showed that the microbiome profile composed of Fusobacterium, Prevotella, Capnocytophaga, and Oribacterium were more abundant in the group with congenital heart disease than in the group without congenital heart disease. Also, the greater number of missing teeth was associated with an increased risk of a first acute myocardial infarction, and endodontic inflammatory disease may contribute as an independent risk factor for cardiovascular diseases.

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Section: Resultsmentioning

confidence: 99%

Evidence of the association between endodontic infections and heart diseases: a systematic review

Ribeiro¹,

Santos²,

Assunção³

et al. 2022

MedNEXT

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“…Therefore, it is key to determine the risk factors associated with CVD. The relationship between AP and cVd has been investigated for several decades and numerous reviews or meta-analyses have been published (186)(187)(188)(189). Most studies have found a weak correlation between AP and cVd (186)(187)(188)(189)(190)(191), with only a few disagree (192,193).…”

Section: Cvdmentioning

confidence: 99%

“…The relationship between AP and cVd has been investigated for several decades and numerous reviews or meta-analyses have been published (186)(187)(188)(189). Most studies have found a weak correlation between AP and cVd (186)(187)(188)(189)(190)(191), with only a few disagree (192,193).…”

Section: Cvdmentioning

confidence: 99%

Interaction between apical periodontitis and systemic disease (Review)

Cao

Song

et al. 2023

Int J Mol Med

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Apical periodontitis is an oral common inflammatory disease initiated by infection of pulp chamber and is characterized by destruction and resorption of the periapical bone. As a local infection, pathogens and their products in periapical tissues, as well as inflammatory cytokines produced in periapical lesions, enter the blood circulation, triggering systemic immune responses and leading to the pathogenesis of various types of systemic disease. Therefore, apical periodontitis might be associated with systemic disease rather than solely simple local oral disease. In addition, the existence of a hyperinflammatory state in certain patients with chronic inflammation-related disorder may affect the progression or prognosis of apical periodontitis. However, the association and potential mechanisms between apical periodontitis and systemic diseases remain unclear. An in-depth understanding of the association between apical periodontitis and systemic disease will be useful for both dentists and physicians to eliminate the possible risk factors and promote the healing of apical periodontitis and systemic disease. Thus, the aim of the present review is to introduce the potential relationship between apical periodontitis and systemic disease.

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“…In addition, long-term consequences of oral diseases and tooth loss tend to further influence other mechanisms in the entire body regarding systemic health (e.g., weight loss, diabetes, cardiovascular diseases, dementia, Alzheimer's disease, and spatial cognitive impairment). 5,[7][8][9][10][11] Therefore, a huge amount of effort must be put to develop biomaterials by sorting out oral health problems faced in dentistry. The selection of biomaterials is being done considering the end product's potential physical, chemical, and biological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Atila,

Kumaravel

2023

Biomater. Sci.

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Cardiovascular Disease and Chronic Endodontic Infection. Is There an Association? A Systematic Review and Meta-Analysis

Cited by 12 publications

References 57 publications

Evidence of the association between endodontic infections and heart diseases: a systematic review

Evidence of the association between endodontic infections and heart diseases: a systematic review

Interaction between apical periodontitis and systemic disease (Review)

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

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