Cardiovascular Complications of Eating Disorders

Casiero, Deena; Frishman, William H.

doi:10.1097/01.crd.0000216745.96062.7c

Cited by 211 publications

(165 citation statements)

References 27 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…Whether a similar mechanism occurs in cardiac muscle atrophy associated with bone metastasis is not known, but TGF-␤1 has been shown to regulate ryanodine receptor-mediated sarcoplasmic reticulum Ca 2ϩ oscillations in cardiac myocytes (78). The heart is not spared during malnutrition (19,45), but nutritional supplementation can reverse the cardiac atrophy (49), suggesting a direct link between energy balance and the regulation of heart size. The mechanisms involved in this effect are still being elucidated, but experiments in mouse hearts showed the starvation-induced cardiac atrophy involved a reduction in ATP and subsequent activation of AMPK, leading to autophagy and inhibition of mTOR signaling (111).…”

Section: Pathogenesis Of Cardiac Atrophy In Cancer Cachexia: Protein mentioning

confidence: 99%

The pathogenesis and treatment of cardiac atrophy in cancer cachexia

Murphy

2016

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass associated with significant functional impairment. In addition to a loss of skeletal muscle mass and function, many patients with cancer cachexia also experience cardiac atrophy, remodeling, and dysfunction, which in the field of cancer cachexia is described as cardiac cachexia. The cardiac alterations may be due to underlying heart disease, the cancer itself, or problems initiated by the cancer treatment and, unfortunately, remains largely underappreciated by clinicians and basic scientists. Despite recent major advances in the treatment of cancer, little progress has been made in the treatment of cardiac cachexia in cancer, and much of this is due to lack of information regarding the mechanisms. This review focuses on the cardiac atrophy associated with cancer cachexia, describing some of the known mechanisms and discussing the current and future therapeutic strategies to treat this condition. Above all else, improved awareness of the condition and an increased focus on identification of mechanisms and therapeutic targets will facilitate the eventual development of an effective treatment for cardiac atrophy in cancer cachexia.

show abstract

Section: Pathogenesis Of Cardiac Atrophy In Cancer Cachexia: Protein mentioning

confidence: 99%

The pathogenesis and treatment of cardiac atrophy in cancer cachexia

Murphy

2016

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

“…It is well known that individuals with AN demonstrate cardiac structural (decreased left ventricular mass and wall thickness), functional (left ventricle dysfunction), and electrical (prolonged QT interval and bradycardia) problems. Episodes of sudden death induced by hypokalemia and arrhythmia are common in patients with AN and bulimia nervosa (BN) (6).…”

Section: Introductionmentioning

confidence: 99%

Serum Lipid Levels in Patients with Eating Disorders

Nakai¹,

Noma

Fukusima

et al. 2016

Intern. Med.

View full text Add to dashboard Cite

Objective To evaluate some risk factors for cardiovascular diseases in feeding and eating disorders, the degree of lipid abnormalities was investigated in a large Japanese cohort of different groups of feeding and eating disorders, according to the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 2012 (JAS Guidelines 2012). Methods Participants in the current study included 732 women divided into four groups of feeding and eating disorders: anorexia nervosa, restricting type (AN-R); anorexia nervosa, binge-eating/purging type; bulimia nervosa (BN); and binge-eating disorder (BED). We measured the serum levels of total cholesterol, highdensity-lipoprotein (HDL) cholesterol, and triglyceride in these participants. Low-density-lipoprotein (LDL) cholesterol and non-HDL cholesterol levels were also calculated. Results The concentrations of LDL cholesterol and non-HDL cholesterol were widely distributed in all groups. When the LDL cholesterol risk was defined as ! 120 mg/dL and the non-HDL cholesterol risk as ! 150 mg/dL, according to the JAS Guidelines 2012, the proportion of LDL cholesterol risk ranged from 29.6% (BN) to 38.6% (AN-R), and the proportion of non-HDL cholesterol risk ranged from 17.8% (BN) to 30.1% (BED). Conclusion The present findings suggest the existence of LDL cholesterol risk and non-HDL cholesterol risk in all groups of eating disorders. Given the chronicity of this condition, the development of elevated concentrations of LDL cholesterol and non-HDL cholesterol at an early age may increase the risk of cardiovascular diseases.

show abstract

“…Nagy hatással bírnak az egész-ségi állapotra és életminőségre (Túry & Szabó, 2000), sokféle orvosi szövődménnyel jár-nak (Casiero & Frishman, 2006;Mitchell & Crow, 2006;Páli & Pászthy, 2008;Pászthy, 2007Péter, Kelemen, & Pászthy, 2008;Szabó & Túry, 1994a) gyakran társulnak más pszichiátriai betegséggel (Blinder, Cumella, & Sanathara, 2006;Szabó & Túry, 1994b;Touchette et al, 2011), és nagy a krónikussá válás esélye (Túry & Pászthy, 2008;Túry & Szabó, 2000. Az evészavarok a legnagyobb mortalitással járó pszichiátriai betegségek: az anorexia nervosa halálozása a betegség kezdetétől számítva 10 éven belül 8%, 20 éven belül 20% (Arcelus, Mitchell, Wales, & Nielsen, 2011;Crow et al, 2009a;Rosling, Sparén, Norring, & von Knorring, 2011;Suzuki, Takeda, & Yoshino, 2011).…”

Section: A Leggyakoribb Evészavarokunclassified

Eating Disorders and School. Risk Factor or the Site of Prevention?

Ludányi¹,

Szabó²

2017

Magyar Pedagógia

View full text Add to dashboard Cite

Evészavarokon olyan tünetcsoportokat értünk, amelyek középpontjában a táplálékfelvétel és a testsúly rendellenessége, illetve a táplálékfelvétellel és testsúllyal kapcsolatos viselkedéses és pszichológiai tünetek állnak. A hazai szakirodalom táplálkozászavarként, étke-zési zavarként, evészavarként vagy a táplálkozási magatartás zavaraként tárgyalja ezeket a zavarokat. Ezen megnevezések közül -egyszerűsége és rövidsége miatt -az evészavar használata tűnik a legcélszerűbbnek. Az evészavar az angol és német kifejezés (eating disorder, Essstörung) tükörfordításának felel meg. A pedagógusok -képzésük és tovább-képzéseik során -kevés információval rendelkeznek az evészavarokról, így célkitűzésünk az, hogy áttekintést nyújtsunk az evészavarok jelenségköréről, illetve arról, hogy az iskolának és a pedagógusoknak milyen szerepük lehet az evészavarok kialakulásában és megelőzésében.

show abstract

Cardiovascular Complications of Eating Disorders

Cited by 211 publications

References 27 publications

The pathogenesis and treatment of cardiac atrophy in cancer cachexia

The pathogenesis and treatment of cardiac atrophy in cancer cachexia

Serum Lipid Levels in Patients with Eating Disorders

Eating Disorders and School. Risk Factor or the Site of Prevention?

Contact Info

Product

Resources

About