Cardiovascular Chronobiology: Do You Know What Time It Is?

Bridges, Elizabeth; Woods, Susan L.

doi:10.1111/j.1751-7117.2001.tb00238.x

Cited by 3 publications

(1 citation statement)

References 110 publications

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“…It is well appreciated by emergency and critical care nurses (Bridges & Woods, 1998, 2001) as well as paramedics that there is a significant circadian rhythm to the incidence of SCA. However, some discrepancy on circadian timing exists, which may be dependent upon patient characteristics (sex, age, etc.)…”

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confidence: 99%

Circadian Rhythms in Sudden Cardiac Arrest

2021

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Background: Sudden cardiac arrest (SCA) is a serious public health issue caused by the cessation of cardiac electrical and mechanical activity. Despite advances in pedestrian lifesaving technologies like defibrillators, the SCA mortality rate remains high, and survivors are at risk of suffering ischemic injury to various organs. Understanding the contributing factors for SCA is essential for improving morbidity and mortality. One factor capable of influencing SCA incidence and survival is the time of day at which SCA occurs.Objectives: This review focused on the effect of time of day on SCA incidence, survival rate, and survival to discharge over the past 30 years and the role of age, sex, and SCA location in modulating the timing of SCA.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews criteria guided this review. Four databases (PubMed, Cochrane Libraries, Scopus, and Cumulative Index to Nursing and Allied Health Literature) were queried for research reports or articles addressing time of day and cardiac arrest, which were subsequently screened by the authors for inclusion in this analysis.Results: A total of 48 articles were included in the final analysis. This analysis showed a bimodal SCA distribution with a primary peak in the morning and a secondary peak in the afternoon; these peaks were dependent on age (older persons), sex (more frequent in males), and the location of occurrence (out-of-hospital cardiac arrest vs. in-hospital cardiac rest). Survival following SCA was lowest between midnight and 06:00 a.m.Discussion: The circadian rhythm likely plays an important role in the time-of-day-dependent pattern that is evident in both the incidence of and survival following SCA. There is a renewed call for nursing research to examine or address circadian rhythm as an element in studies involving older adults and activities affecting cardiovascular or respiratory parameters.

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Circadian Rhythms in Sudden Cardiac Arrest

2021

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Ambulatory Applications for Monitoring Physiological Parameters

Yucha

Tsai

Calderon

2003

Biomedical Technology and Devices Handbook

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Influences of the circadian clock on neuronal susceptibility to excitotoxicity

Karmarkar

Tischkau

2013

Front. Physiol.

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Stroke is the third leading cause of death and the primary cause of morbidity in the United States, thus posing an enormous burden on the healthcare system. The factors that determine the risk of an individual toward precipitation of an ischemic event possess a strong circadian component as does the ischemic event itself. This predictability provided a window of opportunity toward the development of chronopharmaceuticals which provided much better clinical outcomes. Experiments from our lab showed for the first time that neuronal susceptibility to ischemic events follows a circadian pattern; hippocampal neurons being most susceptible to an ischemic insult occurring during peak activity in a rodent model of global cerebral ischemia. We also demonstrated that the SCN2.2 cells (like their in vivo counterpart) are resistant to excitotoxicity by glutamate and that this was dependent on activation of ERK signaling. We are currently working on elucidating the complete neuroprotective pathway that provides a barricade against glutamate toxicity in the SCN2.2 cells. Our future experiments will be engaged in hijacking the neuroprotective mechanism in the SCN2.2 cells and applying it to glutamate-susceptible entities in an effort to prevent their death in the presence of excitotoxicity. Despite the advancement in chronopharmaceuticals, optimal clinical outcome with minimal adverse events are difficult to come by at an affordable price. Superior treatment options require a better understanding of molecular mechanisms that define the disease, including the role of the circadian clock.

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Cardiovascular Chronobiology: Do You Know What Time It Is?

Cited by 3 publications

References 110 publications

Circadian Rhythms in Sudden Cardiac Arrest

Circadian Rhythms in Sudden Cardiac Arrest

Ambulatory Applications for Monitoring Physiological Parameters

Influences of the circadian clock on neuronal susceptibility to excitotoxicity

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