Cardiovascular Biomarkers in Exhaled Breath

Cikach, Frank; Dweik, Raed A.

doi:10.1016/j.pcad.2012.05.005

Cited by 100 publications

(81 citation statements)

References 69 publications

(88 reference statements)

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“…27 For example, exhaled nitric oxide produced during exercise reflects vascular endothelial dysfunction and has been associated with increased mortality in chronic HF. 28 In patients with HF, EAC has been previously reported as a biomarker associated with plasma BNP level and NYHA class.…”

Section: Discussionmentioning

confidence: 99%

Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart Failure

Yokokawa

Sugano

Shimouchi

et al. 2016

Circ J

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Background:We hypothesized that exhaled acetone concentration (EAC), reflecting altered blood ketone body metabolism and increased acetone exhaust because of pulmonary congestion in heart failure (HF), would correlate with hemodynamic parameters in patients with non-ischemic chronic HF. Methods and Results:We prospectively enrolled 102 non-ischemic HF patients with New York Heart Association (NYHA) class I-III. Exhaled breath was collected after an overnight fast. Echocardiography and cardiac catheterization were performed in all patients. We also enrolled 17 control patients without HF. EAC in the HF patients was significantly higher than that in the control patients (median EAC; 0.53 vs. 0.38 ppm, P=0.012). EAC positively correlated with blood total ketone bodies (r=0.454, P<0.001), NYHA class (r=0.489, P<0.001), and plasma B-type natriuretic peptide (r=0.316, P=0.001). Right heart catheterization revealed that EAC significantly correlated with pulmonary capillary wedge pressure (PCWP, r=0.377, P<0.001). Receiver-operating characteristic analysis revealed that EAC >1.05 ppm was associated with PCWP ≥18 mmHg (area under the curve [AUC] 0.726, sensitivity 50%, specificity 89%). EAC was shown to be a comparable diagnostic biomarker for HF to BNP (AUC 0.760, sensitivity 80%, specificity 70%).Conclusions: EAC may be a novel noninvasive biomarker that correlates hemodynamic severity in non-ischemic chronic HF. (Circ J 2016; 80: 1178 -1186

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Section: Discussionmentioning

confidence: 99%

Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart Failure

Yokokawa

Sugano

Shimouchi

et al. 2016

Circ J

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“…Breath alcohol tests are widely employed by law enforcement to provide evidence of recent alcohol consumption during roadside stops. Exhaled breath analysis also is evolving as a new frontier in lung and cardiovascular disease testing (31–32). …”

Section: Discussionmentioning

confidence: 99%

Cannabinoids in Exhaled Breath following Controlled Administration of Smoked Cannabis

et al. 2013

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“…It is thought to be formed following the mevalonic acid (MVA) pathway (Fig. 3) of cholesterol biosynthesis [2, 40, 61–64]. The formation of mevalonate from acetic acid is a crucial chemical reaction in the cholesterol biosynthesis.…”

Section: Origin and Biochemical Pathways Of Major Vocs In Human Exhalmentioning

confidence: 99%

“…Commonly used methods for the analysis of exhaled breath VOCs are GC, GC–MS, and GC with tandem MS (GC–MS 2 ) [4, 7, 61, 98]. In practice, GC/MS systems are often associated with other methods, e.g., solid-phase extraction (SPE) and solid-phase microextraction (SPME), for the analysis of breath VOCs [1].…”

Section: Analytical Techniques Applied In Exhaled Breath Voc Analysismentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.

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Cardiovascular Biomarkers in Exhaled Breath

Cited by 100 publications

References 69 publications

Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart Failure

Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart Failure

Cannabinoids in Exhaled Breath following Controlled Administration of Smoked Cannabis

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

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