Cardiovascular Autonomic Function and Incident Chronic Obstructive Pulmonary Disease Hospitalizations in Atherosclerosis Risk in Communities

MacDonald, David M; Ji, Yuekai; Adabag, Selçuk; Alonso, Álvaro; Chen, Lin Y.; Henkle, Benjamin; Juraschek, Stephen P; Norby, Faye L.; Lutsey, Pamela L.; Kunisaki, Ken M.

doi:10.1513/annalsats.202211-964oc

Cited by 5 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an important study presented in this issue of AnnalsATS , MacDonald and colleagues (pp. 1435–1444 ) used data from the ARIC (Atherosclerosis Risk in Communities) study to examine whether better cardiovascular autonomic function, indicated by higher HRV and appropriate control of orthostatic blood pressure, is associated with a reduced risk of incident COPD hospitalization and lower mortality due to chronic lower respiratory disease ( 10 ). Their findings suggest that individuals with better cardiovascular autonomic function (i.e., greater HRV and better orthostatic blood pressure control) indeed have a lower risk of COPD hospitalization over a median of nearly 27 years of follow-up.…”

mentioning

confidence: 99%

The Autonomous Nervous System: A Novel and Potentially Modifiable Risk Factor for Chronic Obstructive Pulmonary Disease in the Population?

Hamrefors

2023

Annals ATS

View full text Add to dashboard Cite

mentioning

confidence: 99%

The Autonomous Nervous System: A Novel and Potentially Modifiable Risk Factor for Chronic Obstructive Pulmonary Disease in the Population?

Hamrefors

2023

Annals ATS

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease and cardiovascular disease: mechanistic links and implications for practice

Maeda,

Dransfield

2023

Current Opinion in Pulmonary Medicine

View full text Add to dashboard Cite

Purpose of reviewChronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are both significant burdens on the healthcare system and often coexist. Mechanistic links between the two conditions and their clinical impact are increasingly understood.Recent findingsRecent studies demonstrate multiple mechanisms by which the pathobiology of COPD may have negative effects on the cardiovascular system. These include extrapulmonary consequences of the COPD inflammatory state, cardiac autonomic dysfunction, which has been recently implicated in worsening respiratory symptoms and exacerbation risk, and mechanical effects of lung hyperinflation on left ventricular diastolic function.Clinical studies have consistently shown a high prevalence of CVD in COPD patients and worsened outcomes (andvice versa). Exacerbations of COPD have also been demonstrated to dramatically increase the risk of cardiovascular events. While some safety concerns exist, medications for COPD and cardiovascular disease should be used in accordance with respective guidelines. However, real-world data show suboptimal management for patients with COPD and CVD.SummaryCOPD and cardiovascular disease have complicated interrelationships. Further mechanistic studies may lead to defining better targets for interventions. Education for medical professionals and implementation of novel screening protocols should be encouraged to fill in the gaps in clinical care for these patients.

show abstract

Cardiac comorbidity and COPD: chance or consequence?

Maeda,

Dransfield

2024

COPD in the 21st Century

View full text Add to dashboard Cite

Cardiovascular Autonomic Function and Incident Chronic Obstructive Pulmonary Disease Hospitalizations in Atherosclerosis Risk in Communities

Cited by 5 publications

References 46 publications

The Autonomous Nervous System: A Novel and Potentially Modifiable Risk Factor for Chronic Obstructive Pulmonary Disease in the Population?

The Autonomous Nervous System: A Novel and Potentially Modifiable Risk Factor for Chronic Obstructive Pulmonary Disease in the Population?

Chronic obstructive pulmonary disease and cardiovascular disease: mechanistic links and implications for practice

Cardiac comorbidity and COPD: chance or consequence?

Contact Info

Product

Resources

About