Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: Similarities and differences

Assessment of autonomic dysfunction in Parkinson patients by electrocardiogram / Parkinson hastalarında otonomik disfonksiyonun EKG ile değerlendirilmesi

“…Prolongation of QT interval which is concomitant with ventricular arrhythmia has been related to unexpected cardiovascular deaths (1). QT prolongation and sudden death have been reported due to autonomic dysfunction in patients with PD and multi-system atrophy (MSA) in the literature (1,(3)(4)(5)(6). For this reason, QT interval is important for follow-up and treatment of these patients.…”

“…Cardinal symptoms of the disease are resting tremor, reduction in voluntary and associated movements, increase in tonus as rigidity and postural instability. In addition to these symptoms, autonomous symptoms and signs due to degeneration of spinal autonomous neurons and side effects of medications used to treat the disease particularly in advanced stages of disease (1,2). Prolongation of QT interval due to autonomic dysfunction was observed in Parkinson patients in the literature and sudden deaths due to this finding were reported (1).…”

Svimmelhet til besvær

“…Tilstanden varierer i alvorlighetsgrad fra helt lette symptomer til alvorligere, som falltendens og besvimelse. Svimmelhet er mest typisk, men pasientene kan også få symptomer som tretthet, muskelsvakhet, konsentrasjonsvansker eller synsforstyrrelser, og i tilfeller med vedvarende ortostatisk hypotensjon eller større blodtrykksfall kan synkope inntreffe (1,2). Ortostatisk hypotensjon er vanlig ved sykdommer som medfører svekket funksjon i det autonome nervesystemet, som Parkinsons sykdom, multisystematrofi (MSA) og autonome nevropatier.…”

“…En viktig grunn til å avklare om det foreligger nevrogen årsak, er faren for større svingninger i blodtrykket pga. svekket baroreseptorfunksjon (1,2). En konsekvens av dette er økt forekomst av hypertensjon i liggende stilling.…”

Analysis of the Synergistic Effects of Fasting Plasma Glucose and Hypertension on Cardiovascular Autonomic Neuropathy

“…Recent studies have indicated that CAN is associated with many other majority segments of the general population, such as the elderly and patients with HTN and metabolic disorders [5,7,8]. Studies have provided evidence that CAN is common in persons with an impaired glucose tolerance.…”