Cardiovascular autonomic dysfunction in diabetes mellitus.

Barkai, László; Madácsy, László

doi:10.1136/adc.73.6.515

Cited by 39 publications

(45 citation statements)

References 21 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prasad et al studied cardiac autonomic dysfunction and ECG abnormalities in patients with Type II diabetes and found increased frequency of postural hypotension in patients with diabetes compared to healthy controls. Finding of the present study is in accordance with studies done by Jayabal et al [4] and Prasad et al [5] studies done in the past by Ewing et al, [6] Dyrberg et al, [7] Popovic et al, [8] Beylot et al, [9] and Barkai and Madacsy [10] had similar results. It can thus be concluded that the heart rate response to standing, a measure of cardiac parasympathetic function is reduced in uncontrolled diabetes patient groups compared to controls.…”

Section: Jayabal Et Al Studied Autonomic Function Test In Patients Withsupporting

confidence: 83%

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Suhail¹,

Hatekar²,

Daimi³

et al. 2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

Background: In India, more than 50% of patients with Type II diabetes have poor glycemic control and these patients suffer from complications of diabetes. One of the major complications of diabetes is impaired cardiovascular autonomic reflexes. Postural tachycardia index, blood pressure (BP) response to sustained handgrip (SHG), and BP response to standing these tests are used to assess cardiovascular autonomic responses. Aims and Objectives: This study was done to assess cardiovascular responses to SHG and change in posture in Type II diabetes mellitus patients. Materials and Methods: A total of 90 participants were selected out, of which 30 participants had uncontrolled diabetes, 30 had controlled diabetes, and remaining were 30 age-and gender-matched healthy controls. Postural tachycardia index, BP response to SHG, and BP response to standing were measured using Physiopac-8: Computerized 8-channel biopotential acquisition system and Omron Intellisense M3 BP monitor. Data obtained were analyzed statistically. Results: Postural tachycardia index values were significantly lower in uncontrolled diabetes patient group as compared to controlled diabetes patient group and healthy control group. The value of BP response to sustained handgrip in uncontrolled diabetes patient group was significantly lower as compared to healthy controls (P < 0.01), whereas no statistically significant difference observed between uncontrolled and controlled diabetes patient groups (P = 0.35). The value of BP response to standing was significantly higher in uncontrolled diabetes patient group as compared healthy controls (P < 0.01), there is a progressive increase in value of fall of BP to standing from healthy control group to uncontrolled diabetes patient group. Value of fall in BP is more in both controlled and uncontrolled diabetes patient group compared to controls but value is greater in patients with uncontrolled diabetes. Conclusion: Poor glycemic control leads to impairment of cardiovascular response to change in posture and SHG in Type II diabetes mellitus patients.

show abstract

Section: Jayabal Et Al Studied Autonomic Function Test In Patients Withsupporting

confidence: 83%

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Suhail¹,

Hatekar²,

Daimi³

et al. 2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

show abstract

“…The heart rate variability may be diminished in patients with diabetes due to cardiovascular autonomic neuropathy. It has been observed that in adult patients with diabetes, there is dysfunction of the autonomic nervous system with the long duration of the disease [26][27][28][29] . Diabetic autonomic neuropathy is accompanied at first by disorders of the parasympathetic and later, of the sympathetic system 28 .…”

Section: Discussionmentioning

confidence: 99%

“…It has been observed that in adult patients with diabetes, there is dysfunction of the autonomic nervous system with the long duration of the disease [26][27][28][29] . Diabetic autonomic neuropathy is accompanied at first by disorders of the parasympathetic and later, of the sympathetic system 28 . Our assessment of the HRV changes supports the view that there is a decrease in autonomic function early in the development of diabetes and that diabetes leads to a progressive decline in autonomic function and that heart rate variability may be an efficient method for early detection of diabetic autonomic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Efeito da respiração diafragmática sobre a variabilidade da frequência cardíaca na doença cardíaca isquêmica com diabete

Kulur

Haleagrahara

Adhikary

et al. 2009

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…During the sleep state, especially during REM sleep, cardiorespiratory function comes predominantly under sympathetic control [32,33]. An unstable sympathetic system poses a real threat to life and it is important to note that our patients' apnoeic events occurred mainly in the REM stage.…”

Section: Discussionmentioning

confidence: 99%

Sleep apnoea in children with diabetes mellitus: effect of glycaemic control

et al. 2000

View full text Add to dashboard Cite

Autonomic neuropathy is a frequent complication of diabetes mellitus and an additional risk factor for sudden death [1±5]. The autonomic dysfunction associated with diabetes mellitus is shown by changes in cardiovascular [3], gastrointestinal and genitourinary system dysfunction, pupillary dysfunction [6±7] and abnormal sweating [8]. The current consensus is that the syndrome of diabetic neuropathy has a relatively early, adolescent onset and develops earlier and more frequently than had previously been thought [3]. The syndrome causes diffuse functional changes [4], the most feared being changes in heart rhythm [9±10], because they pose a risk of death from cardiac arrest, especially during or immediately after surgical interventions [11±14]. Some of these presumed cardiac events might actually be respiratory arrests, resulting from an alter- AbstractAims/hypothesis. Patients with diabetes mellitus commonly have cardiovascular autonomic dysfunction and an abnormal ventilatory pattern during sleep. Few data are available on these changes in childhood diabetes. We investigated whether young diabetic children with or without diabetic neuropathy have ventilatory dysfunction during sleep and if so, whether these autonomic changes are related to the duration of diabetes and glycaemic control. Methods. We studied 25 children with insulin-dependent diabetes mellitus (19 boys, mean age 7.72 1.99 years). All patients were insulin-dependent at diagnosis; blood samples for HbA 1 c assay were collected on the morning before testing and at 3-month intervals during the preceding year. Patients and control subjects (20 age-matched healthy children, 15 boys) underwent overnight polysomnography. Results. More diabetic patients than control subjects had sleep apnoeas (p = 0.006); apnoeas in patients also lasted longer (p = 0.07). Patients with poorly controlled diabetes had more apnoeas than patients with well±controlled diabetes and than healthy control subjects (p < 0.0001). Respiratory events during sleep correlated significantly with glycaemic control (r = 0.360; p = 0.09) and with the duration of diabetes (r = 0.430; p = 0.04). Conclusion/interpretation. We conclude that respiratory control is compromised very early in children with diabetes. These anomalies are closely related to the duration of diabetes and to glycaemic control. In young children with diabetes, screening of ventilatory control using recording techniques that are simpler than polysomnography could provide an early indication that an adverse cardiopulmonary reaction has begun. [Diabetologia (2000) 43: 696±702] Keywords Sleep apnoea, diabetes, children, autonomic nervous dysfunction, glycaemic control. Corresponding author: Dr M. P. Villa, II Cattedra di Clinica Pediatrica, Policlinico Umberto I, Viale Regina Elena, 324, 00161 Roma, Italy Abbreviations: TSH, Thyroid stimulating hormone; REM, rapid eye movement; NREM, non rapid eye movement; FEV 1 , forced expiratory volume at 1 second; FVC, forced vital capacity; FEF 25±75 , forced expiratory flow at 25±7...

show abstract

Cardiovascular autonomic dysfunction in diabetes mellitus.

Cited by 39 publications

References 21 publications

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Study of cardiovascular responses to sustained handgrip and change in posture in Type II diabetes mellitus patients

Efeito da respiração diafragmática sobre a variabilidade da frequência cardíaca na doença cardíaca isquêmica com diabete

Sleep apnoea in children with diabetes mellitus: effect of glycaemic control

Contact Info

Product

Resources

About