Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease

Oka, Hiroyuki; Morita, Masayo; Onouchi, Kenji; Yoshioka, Masayuki; Mochio, Soichiro; Inoue, Kiyoharu

doi:10.1016/j.jns.2007.01.002

Cited by 51 publications

(30 citation statements)

References 40 publications

(48 reference statements)

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“…For example, PD is associated with a reduction in sympathetic nervous system activity, and patients often display basal hypotension and bradycardia (Oka et al, 2007). It is feasible that (Ϯ)propranolol might exacerbate these symptoms.…”

Section: Discussionmentioning

confidence: 99%

Behavioral and Cellular Modulation of l-DOPA-Induced Dyskinesia by β-Adrenoceptor Blockade in the 6-Hydroxydopamine-Lesioned Rat

Lindenbach¹,

Ostock²,

Jaunarajs³

et al. 2011

J Pharmacol Exp Ther

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Chronic dopamine replacement therapy in Parkinson's disease (PD) leads to deleterious motor sequelae known as L-DOPAinduced dyskinesia (LID). No known therapeutic can eliminate LID, but preliminary evidence suggests that dl-1-isopropylamino-3-(1-naphthyloxy)-2-propanol [(Ϯ)propranolol], a nonselective ␤-adrenergic receptor (␤AR) antagonist, may reduce LID. The present study used the rat unilateral 6-hydroxydopamine model of PD to characterize and localize the efficacy of (Ϯ)propranolol as an adjunct to therapy with L-DOPA. We first determined whether (Ϯ)propranolol was capable of reducing the development and expression of LID without impairing motor performance ON and OFF L-DOPA. Coincident to this investigation, we used reverse-transcription polymerase chain reaction techniques to analyze the effects of chronic (Ϯ)propranolol on markers of striatal activity known to be involved in LID. To determine whether (Ϯ)propranolol reduces LID through ␤AR blockade, we subsequently examined each enantiomer separately because only the (Ϫ)enantiomer has significant ␤AR affinity. We next investigated the effects of a localized striatal ␤AR blockade on LID by cannulating the region and microinfusing (Ϯ)propranolol before systemic L-DOPA injections. Results showed that a dose range of (Ϯ)propranolol reduced LID without deleteriously affecting motor activity. Pharmacologically, only (Ϫ)propranolol had anti-LID properties indicating ␤AR-specific effects. Aberrant striatal signaling associated with LID was normalized with (Ϯ)propranolol cotreatment, and intrastriatal (Ϯ)propranolol was acutely able to reduce LID. This research confirms previous work suggesting that (Ϯ)propranolol reduces LID through ␤AR antagonism and presents novel evidence indicating a potential striatal locus of pharmacological action.

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Section: Discussionmentioning

confidence: 99%

Behavioral and Cellular Modulation of l-DOPA-Induced Dyskinesia by β-Adrenoceptor Blockade in the 6-Hydroxydopamine-Lesioned Rat

Lindenbach¹,

Ostock²,

Jaunarajs³

et al. 2011

J Pharmacol Exp Ther

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“…У пациентов с ДТЛ падение АД при стоянии сохраняется в течение длительного пе-риода времени [20]. Концентрация норадреналина в плазме крови у больных ДТЛ также остается низкой [55,56]. Для констатации тенденции к фиксирован-ности пульса оценивают его изменения при глубо-ком дыхании, пробе Вальсальвы (натуживание), из-менении положения тела, изометрической нагрузке.…”

Section: диагностика ог при дтлunclassified

Orthostatic hypotension in dementia with Lewy bodies

Чимагомедова¹,

Левин²

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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ГБОУ ДПО «Российская медицинская академия последипломного образования», Москва, Россия В обзоре рассматриваются особенности проявления ортостатической гипотензии при деменции с тельцами Леви и методы ее диагностики. Ранняя диагностика данных нарушений позволит предотвратить такие нежелательные последствия, как падения и обмороки, улучшить повседневную деятельность и повысить качество жизни пациентов. анализируются современные подходы к коррекции данного состояния. The features of orthostatic hypotension in patients with dementia with Lewy bodies are considered. The early diagnosis of these disorders could prevent adverse conditions (falls and syncopes), improve activities of daily living and quality-of-life. Current approaches to treatment of orthostatic hypotension are analyzed.

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“…DLB's typical symptoms include cognitive impairment, visual hallucinations, spontaneous parkinsonism, and fluctuating confusion in addition to autonomic failure [Hanson and Lippa, 2009]. Autonomic dysfunction is more severe in DLB than in PD [Oka et al 2007a;Kaufmann et al 2004;Thaisetthawatkul et al 2004].…”

Section: Parkinson's Disease and Dysautonomiamentioning

confidence: 99%

Review: Treatment of dysautonomia in extrapyramidal disorders

Ziemssen

Reichmann

2009

Ther Adv Neurol Disord

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Although extrapyramidal diseases are commonly thought to solely affect the extrapyramidal motor system, nonmotor symptoms such as behavioural abnormalities, dysautonomia, sleep disturbances and sensory dysfunctions are also frequently observed. Autonomic dysfunction as an important clinical component of extrapyramidal disease (idiopathic Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, dementia with Lewy bodies) is often not formally assessed and thus frequently misdiagnosed. Symptoms of autonomic dysfunction in general impact more on quality of life than motor symptoms. Appropriate symptom-oriented diagnosis and symptomatic treatment as part of an interdisciplinary approach can greatly benefit the patient. Unfortunately, double-blind, randomized, controlled studies are scarce with the consequence that most recommendations are not based on the highest level of evidence. This review elaborates a limited overview on the treatment of cardiovascular, gastrointestinal, urogenital and sudomotor autonomic dysfunction in various extrapyramidal syndromes.

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Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease

Cited by 51 publications

References 40 publications

Behavioral and Cellular Modulation of l-DOPA-Induced Dyskinesia by β-Adrenoceptor Blockade in the 6-Hydroxydopamine-Lesioned Rat

Behavioral and Cellular Modulation of l-DOPA-Induced Dyskinesia by β-Adrenoceptor Blockade in the 6-Hydroxydopamine-Lesioned Rat

Orthostatic hypotension in dementia with Lewy bodies

Review: Treatment of dysautonomia in extrapyramidal disorders

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