Cardiovascular Autonomic Adaptation to Long-Term Confinement During a 105-Day Simulated Mars Mission

Wan, Li; Ogrinz, Barbara; Vigo, Daniel Eduardo; Bersenev, E. Yu.; Tuerlinckx, Francis; Bergh, Omer Van den; Aubert, André

doi:10.3357/asem.2986.2011

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Moderate but significant body weight and plasma volume loss were reported in 28, 60 and 105 day confinement study [10], [11], [13] while in the present one despite the subjects reduced slightly their physical activity and changed their salt intake no body weight nor water content loss was reported [16]. Thus the vessel wall change measured during MARS 500 could not be related to significant hemodynamic changes.…”

Section: Discussionmentioning

confidence: 38%

“…Carotid and femoral results suggest that the main peripheral arterial flows remained stable as expected, because in absence of gravity change there would be no fluid redistribution between the main vascular compartment, nor a decrease in plasma volume as observed in bedrest or spaceflight [1] , [4] . Moderate but significant body weight and plasma volume loss were reported in 28, 60 and 105 day confinement study [10] , [11] , [13] while in the present one despite the subjects reduced slightly their physical activity and changed their salt intake no body weight nor water content loss was reported [16] . Thus the vessel wall change measured during MARS 500 could not be related to significant hemodynamic changes.…”

Section: Discussionmentioning

confidence: 43%

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Adaptation of the Main Peripheral Artery and Vein to Long Term Confinement (MARS 500)

Arbeille

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Vincent³

et al. 2014

PLoS ONE

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PurposeThe objective was to check if 520 days in confinement (MARS 500), may affect the main peripheral arterial diameter and wall thickness and the main vein size.MethodCommon carotid (CC) femoral artery (FA) portal vein (PV), jugular (JG), femoral vein (FV) and tibial vein were assessed during MARS 500 by echography, performed by the subjects. A hand free volumic echographic capture method and a delayed 3D reconstruction software developed by our lab were used for collecting and measuring the vascular parameters.ResultsDuring the MARS 500 experiment the subjects performed 6 sessions among which 80% of the echographic data were of sufficient quality to be processed. No significant change was found for the Common carotid, Jugular vein, femoral artery, femoral vein, portal vein, and tibial vein diameter. CC and FA IMT (intima media thickness) were found significantly increased (14% to 28% P<0.05) in all the 6 subjects, during the confinement period and also at +2 days after the confinement period, but there was no significant difference 6 month later compare to pre MARS 500.ConclusionThe experiment confirmed that even untrained to performing echography the subjects were able to capture enough echographic data to reconstruct the vessel image from which the parameters were measured. The increase in both CC and FA IMT should be in relation with the stress generated by the confined environment or absence of solar radiation, as there was no change in gravity, temperature and air in the MARS 500 module, and minor changes in physical exercise and nutrition.

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Section: Discussionmentioning

confidence: 38%

Section: Discussionmentioning

confidence: 43%

Adaptation of the Main Peripheral Artery and Vein to Long Term Confinement (MARS 500)

Arbeille

Provost

Vincent³

et al. 2014

PLoS ONE

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“…In order to prepare for a manned space flight to Mars, a 105-day pilot study and a 520-day study has been carried out to simulate a mission to Mars, where a small crew was confined for 520 days, hereby mimicking the time necessary to travel back and forth to Mars and the tasks they would have to perform. During these preparation studies, the cardiovascular response to the prolonged confinement was evaluated (Vigo et al, 2012(Vigo et al, , 2013Wan et al, 2011). Only the reduction in gravity was not simulated.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular autonomic adaptation in lunar and martian gravity during parabolic flight

et al. 2015

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“…Studies in space life science research in this new lab began following a cooperation established in 2010 with the Katholieke Universiteit Leuven, Belgium, which enabled participation in the Mars500 project (Russian Academy of Sciences, European Space Agency). In the study connected to that project, autonomic profiles associated with prolonged confinement were described (2)(3)(4). In 2012, the "First International Workshop on Human Space Physiology" (http://www.spacelife.com.ar) was held in Argentina, where local and international scientists from Brazil (MicroG-PUCRS) and Europe (DLR, Katholieke Universiteit Leuven) exchanged views regarding possible cooperation opportunities at national and international levels.…”

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confidence: 99%

MicroG Buenos Aires is born: Space and Applied Neuroscience Lab joins the MicroG Labs Network

2015

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brings together four interesting articles, like that entitled "Man-machine interaction in technologically advanced aircraft: transformation of a paradigm". Based on a literature review, this paper presents a discussion of the transformation of aircraft management processes, characterized by the increasing automation of aviation and reflecting on the man-machine interaction in technologically advanced aircraft (TAA).The new edition also includes two interesting contributions from the Brazilian Air Force. The first article, "Analysis of the forces exerted in flight by Aviator Cadets of the Brazilian Air Force", presents an evaluation of muscular force of aviator cadets submitted to a training program in an Aircraft Force Simulator, prototype EMB312/T-27. The second article, "The influence of airsickness on learning and flight instruction of aviator cadets of the Brazilian Air Force", investigates the prevalence of airsickness among aviator cadets of the Brazilian Air Force, based in Pirassununga, São Paulo state, their search for medical treatment and the influence of symptoms on their performance.The fourth paper in this issue, "The relationship between institutions, human factors and operational safety in aviation" examines the relationship between the organization and the individual, in other words, the role of organizational culture on the implementation of human factors in the daily operations of an airline company, and the influence this process has on the level of operational safety.

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Cardiovascular Autonomic Adaptation to Long-Term Confinement During a 105-Day Simulated Mars Mission

Abstract: Our findings are in line with and extend previous findings on the alteration of blood pressure regulation due to long-term confinement.

Cited by 5 publications

References 25 publications

Adaptation of the Main Peripheral Artery and Vein to Long Term Confinement (MARS 500)

Adaptation of the Main Peripheral Artery and Vein to Long Term Confinement (MARS 500)

Cardiovascular autonomic adaptation in lunar and martian gravity during parabolic flight

MicroG Buenos Aires is born: Space and Applied Neuroscience Lab joins the MicroG Labs Network

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