Cardiovascular and Respiratory System Responses and Limitations to Exercise

Rodman, J. R.; Haverkamp, Hans Christian; Gordon, S.; Dempsey, Jerome A.

doi:10.1159/000062206

Cited by 8 publications

(6 citation statements)

References 87 publications

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“…This ventilatory pattern, well described in endurance athletes, offers less expenditure of ventilation in dead space and, therefore, minor work of respiratory muscles (Clark et al 1983;Johnson et al 1992). This pattern could be related to a reduced chemoreceptor sensitivity associated with a lower dyspnoea feeling (Rodman et al 2002;Takano et al 1997). Harms et al showed that minor tiredness in respiratory muscles, which can be experimentally obtained by mechanical unloading of these muscles, allows for a reduction of respiratory muscles _ VO 2 and blood flow and that this phenomenon is associated with more than 10% leg blood flow increase (Harms et al 1995;Harms et al 1997).…”

Section: Discussionmentioning

confidence: 75%

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End-tidal pressure of CO2 and exercise performance in healthy subjects

et al. 2008

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High arterial CO(2) pressure (P(a)CO(2)) measured in athletes during exercise suggests inadequate hyperventilation. End-tidal CO(2) pressure (P (ET)CO(2)) is used to estimate P(a)CO(2.) However, P(ET)CO(2) also depends on exercise intensity (CO(2) production, .VCO2) and ventilation efficiency (being P(ET)CO(2) function of respiratory rate). We evaluated P(ET)CO(2) as a marker, which combines efficiency of ventilation and performance. A total of 45 well-trained volunteers underwent cardiopulmonary tests and were grouped according to P(ET)CO(2) at respiratory compensation (RC): Group 1 (P(ET)CO(2) 35.1-41.5 mmHg), Group 2 (41.6-45.7) and Group 3 (45.8-62.6). At anaerobic threshold, RC and peak exercise, ventilation (.VE) was similar, but in Group 3, a greater tidal volume (Vt) and lower respiratory rate (RR) were observed. Peak exercise workload and .VO2 were lowest in Group 1 and similar between Group 2 and 3. Group 3 subjects also showed high peak .VCO2 suggesting a greater glycolytic metabolism. In conclusion, a high P(ET)CO(2) during exercise is useful in identifying a specific respiratory pattern characterized by high tidal volume and low respiratory rate. This respiratory pattern may belong to subjects with potential high performance.

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Section: Discussionmentioning

confidence: 75%

“…Excessive alveolar to arterial O 2 pressure (DP A-a O 2 ) difference, abnormal increases in arterial CO 2 pressure (P a CO 2 ) and haemoglobin desaturation have been demonstrated (Dempsey and Wagner 1999;Durand et al 2000;Rodman et al 2002).…”

Section: Introductionmentioning

confidence: 99%

End-tidal pressure of CO2 and exercise performance in healthy subjects

et al. 2008

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“…Bu egzersizden sonra kişi aralıklı olarak birçok defa (örneğin 1,3 [6]. Yapılan çalışmalarda metakolin duyarlılık testi bronş aşırı duyarlılığını değerlendirmede daha üstün olduğu gösterilmiştir [22].…”

Section: Egzersiz Ile Indüklenen Bronkospazm (Ei̇b) Testiunclassified

Cardiopulmonary exercise testing

Ceylan

2014

J Clin Exp Invest

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Cardiopulmonary exercise testing (CPET) is a noninvasive procedure that provides diagnostic and prognostic information and evaluates an individual's capacity for dynamic exercise. CPET is an investigation of the respiratory, cardiovascular and cellular response to the exercise that can be done under controlled metabolic conditions. It provides assessment of the integrative exercise responses involving not only the pulmonary and cardiovascular systems but also skeletal muscle system, which are not adequately reflected through the measurement of individual organ system function. Furthermore, it is being performed increasingly in a wide spectrum of clinical applications for evaluation of undiagnosed exercise intolerance or for objective determination of functional capacity. CPET with extensive hardware and educated staffs can be used for the diagnosis of different types of clinical problems. Additionally, the increasing number of applications for which CPET is currently employed, attests to the growing recognition of its importance in medicine. J Clin Exp Invest 2014; 5 (3): 504-509

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“…In the cardiological context, CPET is a well recognized method to diagnose and/or investigate cardiovascular dysfunction (e.g., myocardial ischemia, chronic heart failure) [ 10 , 13 ]. With respect to lung diseases, the goal of CPET is the identification of physiopathological determinants of respiratory dysfunction as well as matching the pattern of the abnormality with the particular sites of the system involved, thus clarifying the clinical picture and possibly narrowing the differential diagnosis [ 14 , 15 ]. Furthermore, the physiological link between respiratory and cardiovascular functions might cause the changes in one system to influence the performance of the other.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic pulmonary fibrosis and coronary artery disease

Cicchitto¹,

Musella²,

Acitorio

et al. 2014

Multidisciplinary Respiratory Medicine

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Idiopathic pulmonary fibrosis (IPF) is defined as a chronic fibrosing interstitial disease of unknown cause, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP); it generally progresses into respiratory failure and death. Although progression of the disease is the most common cause of death, there are increasing reports of its association with other pathologies has been reported: e.g., IPF patients seem more susceptible to cardiovascular diseases. Therefore, other pathologies might also influence the natural course.In this paper, we describe a case of IPF and coronary artery disease (CAD). We emphasize the importance of cardiopulmonary exercise test (CPET) as a useful procedure to monitor disease progression in IPF patients. We also stress the importance of a careful analysis of variables measured for an accurate interpretation of the clinical picture and an improvement of the clinical management of patients. Moreover, we suggest that a careful assessment of CPET parameters may additionally help in the early detection of high cardiovascular ischemic risk.

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Cardiovascular and Respiratory System Responses and Limitations to Exercise

Cited by 8 publications

References 87 publications

End-tidal pressure of CO2 and exercise performance in healthy subjects

End-tidal pressure of CO2 and exercise performance in healthy subjects

Cardiopulmonary exercise testing

Idiopathic pulmonary fibrosis and coronary artery disease

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