Background: Work-related Musculoskeletal Disorders (WRMSDs) constitutes major constraint to optimal performance among workers. However, information about its prevalence and pattern of occurrence among Ghanaians working in gold mine industries remain insufficient. Objective: To determine the prevalence of WRMSDs among workers of AngloGold Ashanti (AGA)-Obuasi mine. Materials and Methods: A cross-sectional survey was conducted with 28-point self-administered questionnaire modified from the Standardized Nordic Musculoskeletal Questionnaire. Quota sampling was applied using ratios according to the number of workers in each department. Data