Cardiovascular and metabolic outcome in 6–8year old offspring of women with type 1 diabetes with near-optimal glycaemic control during pregnancy

Rijpert, Maarten; Evers, Inge M.; Valk, Harold W. de; Vroede, Monique A. M. J. de; Tersteeg-Kamperman, Marijke; Heijnen, Cobi J.; Visser, Gerard H.A.

doi:10.1016/j.earlhumdev.2010.10.002

Cited by 8 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature search identified 94 papers, of which 19 matched the inclusion criteria [11,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (Fig. 1).…”

Section: Literature Searchmentioning

confidence: 99%

“…Two papers mentioned BP, but reported no data [26,41]; the authors were contacted, but were unable to provide the data. Where outcome data were not represented as unadjusted mean and SD [24,30,33,34,36,38,42], the authors were contacted; data were received for all studies.…”

Section: Literature Searchmentioning

confidence: 99%

“…Seven studies provided BP in offspring of mothers with GDM [24,25,29,34,36,39,40], and two in offspring of mothers with type 1 diabetes [32,33]. Four studies included pooled outcome data for offspring of both type 1 diabetes and GDM mothers [28,30,38,42]; one study included data from prepregnancy type 2 diabetes in their pooled diabetic group [28]; authors provided separate data for type 1 diabetes and GDM for three studies [30,38,42].…”

Section: Literature Searchmentioning

confidence: 99%

“…One study provided sex-specific data for offspring BP [29]; authors of all included studies were contacted, and sexspecific data were provided for eight further studies [24,30,33,34,36,38,40,42]. Five studies reported maternal prepregnancy BMI [25,30,36,39,40], and two studies reported offspring SBP data adjusted for prepregnancy maternal BMI [38,39].…”

Section: Literature Searchmentioning

confidence: 99%

“…Study quality A meta-analysis limited to studies scoring ≥5 out of 7 according to the Modified Newcastle-Ottawa Quality Assessment Scale (seven studies for SBP [24,29,30,33,34,36,39], six studies for DBP [24,29,30,33,34,36] Adjusted analyses In five studies, SBP was adjusted for covariates including offspring sex and age [33,34,36,38,39]. A meta-analysis of the adjusted data showed that SBP was higher in ODM than controls (2.43 mmHg [95% CI 0.90, 3.97]; p00.002; random-effects analysis; ESM Fig.…”

Section: Offspring Sex (Nine Studies)mentioning

confidence: 99%

See 4 more Smart Citations

The diabetic pregnancy and offspring blood pressure in childhood: a systematic review and meta-analysis

Aceti¹,

Santhakumaran²,

Logan³

et al. 2012

Diabetologia

110

View full text Add to dashboard Cite

Aims/hypothesis Offspring of diabetic mothers have increased risk of the metabolic syndrome in adulthood. Studies examining BP in offspring of diabetic mothers have conflicting conclusions. We performed a systematic review and metaanalysis of studies reporting offspring BP in children born to diabetic mothers. Methods Citations were identified in PubMed. Authors were contacted for additional data. Systolic and diastolic BP in offspring of diabetic mothers and controls were compared. Subgroup analysis of type of maternal diabetes and offspring sex were performed. Fixed-effects models were used, and random-effects models where significant heterogeneity was present. Meta-regression was used to test the relationship between offspring systolic BP and prepregnancy BMI. Results Fifteen studies were included in the review and 13 in the meta-analysis. Systolic BP was higher in offspring of diabetic mothers (mean difference 1.88 mmHg [95% CI 0.47, 3.28]; p00.009). Offspring of mothers with gestational diabetes had similar diastolic BP to controls, but higher systolic BP (1.39 mmHg [95% CI 0.00, 2.77]; p00.05); results for type 1 diabetes were inconclusive and there were no separate data available on offspring of type 2 diabetic mothers. Male offspring of diabetic mothers had higher systolic BP (2.01 mmHg [95% CI 0.93, 3.10]; p00.0003) and diastolic BP (1.12 mmHg [95% CI 0.36, 1.88]; p00.004) than controls; in female offspring there was no difference (systolic: 0.54 mmHg [95% CI −1.83, 2.90], p00.66; diastolic: 0.51 mmHg [95% CI −1.07, 2.09], p00.52). The correlation between offspring systolic BP and maternal prepregnancy BMI was not significant (p00.37). Conclusions/interpretation Offspring of diabetic mothers have higher systolic BP than controls. Differences related to sex and type of maternal diabetes require further investigation.

show abstract

“…The literature search identified 94 papers, of which 19 matched the inclusion criteria [11,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (Fig. 1).…”

Section: Literature Searchmentioning

confidence: 99%