Cardiovascular and Locomotor Effects of Binary Mixtures of Common “Bath Salts” Constituents: Studies with Methylone, MDPV, and Caffeine in Rats
Robert W. Seaman,
David G. Galindo,
Benjamin T. Stinson
et al.
Abstract:Background and PurposeThe use of “Bath Salts” drug preparations has been associated with high rates of toxicity and death. Preparations often contain mixtures of drugs including multiple synthetic cathinones or synthetic cathinones and caffeine; however, little is known about whether interactions among “Bath Salts” constituents contribute to the adverse effects often reported in users.Experimental ApproachThis study used adult male Sprague-Dawley rats to characterize the cardiovascular effects, locomotor effec… Show more
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