Cardiovascular and hidroelectrolytic changes in rats fed with high-fat diet

Sá, Jéssica Matheus; Barbosa, Rafaela Moreira; Menani, José Vanderlei; Luca, Laurival A. De; Colombari, Eduardo

doi:10.1016/j.bbr.2019.112075

Cited by 8 publications

(6 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…shown in the present study, in which rats fed a HFD showed decreased water intake when compared to control-fed rats. Previous studies showed a similar decrease in water intake, which was accompanied by a decrease in meal frequency (Haleem & Mahmood, 2021;Sá et al, 2019;Volcko et al, 2020). Rats often drink water when ingesting dry food, a behaviour named prandial drinking (Epstein et al, 1964;Teitelbaum & Epstein, 1962), and thus the decrease in basal water intake could be a consequence of decreased food intake.…”

Section: Discussionmentioning

confidence: 67%

“…Previous studies have shown that plasma sodium concentration and urinary sodium excretion were unchanged by HFD (Sá et al., 2019). Basal hypertonic saline ingestion was not changed by HFD, and this result is possibly due to the plasma levels of sodium not changing after HFD.…”

Section: Discussionmentioning

confidence: 89%

“…Although the relationship between obesity and cardiovascular diseases (Jokinen, 2015) and the metabolic changes caused by obesity (Greenberg & Obin, 2006) have been extensively investigated, few studies have assessed the relationship between obesity and hydromineral homeostasis. Previous studies indicate that chronic HFD decreases basal consumption of food and water in rats (Haleem & Mahmood, 2021;Sá et al, 2019;Volcko et al, 2020). Additionally, it has previously been hypothesized that hydration per se increases lipolysis (Thornton et al, 2009) and that chronic mild hypovolaemia is associated with the development of obesity, diabetes and hypertension (Fetissov & Thornton, 2009).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High‐fat diet changes the behavioural and hormonal responses to water deprivation in male Wistar rats

Dos‐Santos

Ishioka

Cognuck

et al. 2022

Experimental Physiology

View full text Add to dashboard Cite

New Findings What is the central question of this study?What is the effect of an obesogenic diet on the control of hydromineral balance in rats? What is the main finding and its importance?The results showed that, when dehydrated, rats fed a high‐fat diet drink less water than their control‐diet‐fed counterparts. Changes in aquaporin‐7 and peroxisome proliferator‐activated receptor α expression in the white adipose tissue might be involved. Abstract High‐fat diet (HFD) increases fat accumulation, glycaemia and blood triglycerides and is used as a model to study obesity. Besides the metabolic changes, obesity likely affects water intake. We assessed the effects of HFD on behavioural and hormonal responses to water deprivation. Additionally, we measured if the adipose tissue is differentially affected by water deprivation in control and HFD‐fed rats. HFD rats showed a decreased basal water intake when compared to control‐fed rats. When subjected to 48 h of water deprivation, as expected, both control and HFD rats drank more water than the hydrated rats. However, the increase in water intake was lessened in HFD dehydrated rats. Similarly, the increase in haematocrit in dehydrated rats was less pronounced in HFD dehydrated rats. These results suggest that HFD diminishes drinking behaviour. White adipose tissue weight, glycaemia and plasma glycerol concentration were increased in HFD rats; however, after 48 h of water deprivation, these parameters were significantly decreased in dehydrated HFD rats, when compared to controls. The increase in adipose tissue caused by HFD may mitigate the effects of dehydration, possibly through the increased production of metabolic water caused by lipolysis in the adipocytes. Oxytocin possibly mediates the lipolytic response, since both its secretion and receptor expression are affected by dehydration in both control and HFD rats, which suggests that oxytocin signalling is maintained in these conditions. Changes in mediators of lipolysis, such as aquaporin‐7 and peroxisome proliferator‐activated receptor α, might contribute to the different effects observed in control and HFD rats.

show abstract

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High‐fat diet changes the behavioural and hormonal responses to water deprivation in male Wistar rats

Dos‐Santos

Ishioka

Cognuck

et al. 2022

Experimental Physiology

View full text Add to dashboard Cite

show abstract

“…Among these, diabetes (Dong et al, 2017 ), inflammation, atherosclerosis (Joseph et al, 2003 ), obesity (Kaess et al, 2014 ), and hypertension (Siri-Tarino and Krauss, 2016 ) are related. The male rats feeding HFD showed increased blood pressure (Sá et al, 2019 ), and Hsu et al ( 2019 ) showed that the consumption of HFD during pregnancy of rats was responsible for inducing hypertension in adult offspring.…”

Section: Discussionmentioning

confidence: 99%

Congenital Anomalies Programmed by Maternal Diabetes and Obesity on Offspring of Rats

et al. 2021

View full text Add to dashboard Cite

Embryo-fetal exposure to maternal disorders during intrauterine life programs long-term consequences for the health and illness of offspring. In this study, we evaluated whether mild diabetic rats that were given high-fat/high-sugar (HF/HS) diet presented maternal and fetal changes at term pregnancy. Female rats received citrate buffer (non-diabetic-ND) or streptozotocin (diabetic-D) after birth. According to the oral glucose tolerance test (OGTT), the experimental groups (n = 11 animals/group) were composed of non-diabetic and diabetic receiving standard diet (S) or HF/HS diet. High-fat/high-sugar diet (30% kcal of lard) in chow and water containing 5% sucrose and given 1 month before mating and during pregnancy. During and at the end of pregnancy, obesity and diabetes features were determined. After laparotomy, blood samples, periovarian fat, and uterine content were collected. The diabetic rats presented a higher glycemia and percentage of embryonic losses when compared with the NDS group. Rats DHF/HS presented increased obesogenic index, caloric intake, and periovarian fat weight and reduced gravid uterus weight in relation to the other groups. Besides, this association might lead to the inflammatory process, confirmed by leukocytosis. Obese rats (NDHF/HS and DHF/HS) showed higher triglyceride levels and their offspring with lower fetal weight and ossification sites, indicating intrauterine growth restriction. This finding may contribute to vascular alterations related to long-term hypertensive disorders in adult offspring. The fetuses from diabetic dams showed higher percentages of skeletal abnormalities, and DHF/HS dams still had a higher rate of anomalous fetuses. Thus, maternal diabetes and/or obesity induces maternal metabolic disorders that contribute to affect fetal development and growth.

show abstract

“…Adequate nutritional status is essential for maintaining cardiovascular structure and functionality in the face of metabolic challenges [ 2 , 70 ]. During the last decade, there has been intensive debate about the advice to reduce SAFA and increase MUFA or polyunsaturated (PUFA) to reduce the risk of CVD [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats

et al. 2021

View full text Add to dashboard Cite

(1) Background: The replacement of diets high in saturated fat (SAFA) with monounsaturated fatty acids (MUFA) is associated with better cardiovascular function and is related to the modulation of the activity of the local renin–angiotensin system (RAS) and the collagenase activity of dipeptidyl peptidase IV (DPP-IV). The objective of the work was to verify the capacity of different types of dietary fat on the regulatory activities of RAS and DPP-IV. (2) Methods: Male Wistar rats were fed for 24 weeks with three different diets: the standard diet (S), the standard diet supplemented with virgin olive oil (20%) (VOO), or with butter (20%) plus cholesterol (0.1%) (Bch). The proteolytic activities were determined by fluorometric methods in the soluble (sol) and membrane-bound (mb) fractions of the left ventricle and atrium, aorta, and plasma samples. (3) Results: With the VOO diet, angiotensinase values were significantly lower than with the Bch diet in the aorta (GluAP and ArgAP (mb)), ventricle (ArgAP (mb)) and atrium (CysAP (sol)). Significant decreases in DPP-IV (mb) activity occurred with the Bch diet in the atrium and aorta. The VOO diet significantly reduced the activity of the cardiac damage marker LeuAP (mb) in the ventricle and aorta, except for LeuAP (sol) in the ventricle, which was reduced with the Bch diet. (4) Conclusions: The introduction into the diet of a source rich in MUFA would have a beneficial cardiovascular effect on RAS homeostasis and cardiovascular functional stability.

show abstract

Cardiovascular and hidroelectrolytic changes in rats fed with high-fat diet

Cited by 8 publications

References 47 publications

High‐fat diet changes the behavioural and hormonal responses to water deprivation in male Wistar rats

High‐fat diet changes the behavioural and hormonal responses to water deprivation in male Wistar rats

Congenital Anomalies Programmed by Maternal Diabetes and Obesity on Offspring of Rats

High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats

Contact Info

Product

Resources

About