Cardiovascular and all-cause mortality in patients with type 2 diabetes mellitus in the MADIABETES Cohort Study: Association with chronic kidney disease

Salinero-Fort, Miguel Á.; Andrés-Rebollo, F. Javier San; Burgos‐Lunar, Carmen de; Abánades-Herranz, Juan Carlos; Pau, Enrique Carrillo de Santa; Chico-Moraleja, Rosa M.; Jiménez‐García, Rodrigo; López‐de‐Andrés, Ana; Gómez-Campelo, Paloma

doi:10.1016/j.jdiacomp.2015.10.007

Cited by 28 publications

(33 citation statements)

References 45 publications

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“…8 The slower decrease in eGFR associated with dulaglutide compared with insulin glargine is especially important given the increased risk of cardiovascular disease and premature mortality associated with comorbid T2D and CKD. 27,28 The LEADER study also found that the slope of the eGFR decrease was attenuated when patients with eGFR <60 and 30 mL/min/1.73 m 2 took liraglutide compared with placebo. 9 Real-world outcomes research is relatively limited regarding renal outcomes with GLP-1 RA treatment, and such studies mostly have included a limited number of participants.…”

Section: T a G G E D H 1 Discussiont A G G E D E N Dmentioning

confidence: 97%

Effects of Dulaglutide and Insulin Glargine on Estimated Glomerular Filtration Rate in a Real-world Setting

Boye

Mody

et al. 2018

Clinical Therapeutics

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Section: T a G G E D H 1 Discussiont A G G E D E N Dmentioning

confidence: 97%

Effects of Dulaglutide and Insulin Glargine on Estimated Glomerular Filtration Rate in a Real-world Setting

Boye

Mody

et al. 2018

Clinical Therapeutics

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“…The MADIABETES Cohort Study showed that the coexistence of CKD in patients with type 2 diabetes mellitus was an independent risk factor for all-cause and CV mortality [11].…”

Section: Diabetes and Hypertensionmentioning

confidence: 99%

“…According to Matsushita et al [14], albuminuria is independently associated with heart mass, systolic and diastolic functions of left ventricle. The level of albumin is currently considered as a potential predictor of mortality and hospitalization risk [15].…”

Section: Diabetes and Hypertensionmentioning

confidence: 99%

Cardiovascular Risk Factors in End-Stage Renal Disease Patients: The Impact of Conventional Dialysis versus Online-Hemodiafiltration

Coimbra¹,

Faria²,

Miranda³

et al. 2018

Aspects in Dialysis

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End-stage renal disease (ESRD) patients present high incidence of cardiovascular (CV) events, which are the most common causes of death in these patients. The occurrence of CV events appears as a consequence of the high prevalence of traditional and nontraditional CV risk factors. Online-hemodiafiltration (OL-HDF) was introduced as a better alternative to conventional dialysis, as it was proposed to be more biocompatible, to increase dialysis efficacy, to reduce the inflammatory response to treatment and to improve patient's quality of life, contributing to reduce CV and all-cause mortality risk in ESRD. However, data in literature, comparing the effect of OL-HDF with conventional dialysis for clinical CV outcome and all-cause mortality, yielded controversy about those benefits of OL-HFD over standard hemodialysis. A review of the traditional CV risk factors (e.g., arterial hypertension, diabetes mellitus, dyslipidemia, obesity, smoking and advanced age), non-traditional risk factors (e.g., anemia, oxidative stress, hyperphosphatemia, endothelial dysfunction, left ventricular hypertrophy, insulin resistance, high levels of lipoprotein(a) and inflammation) and potential renocardiovascular biomarkers, in the setting of ESRD, is presented. The impact of conventional hemodialysis and OL-HDF on CV risk factors and on the outcome of ESRD patients is also addressed.

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“…The Madrid Diabetes Study, which is a prospective cohort study of 3443 type-2 diabetic outpatients, showed that the unadjusted hazard ratio for all-cause mortality in diabetic patients with eGFR < 60 mL/min/1.73 m 2 was approximately 3 after five years of follow-up. Patients with chronic kidney disease at baseline had an increased risk of cardiovascular mortality [24]. …”

Section: The Impact Of Chronic Hyperglycemia On Diabetic Complicationmentioning

confidence: 99%

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

Pereira

Pimenta

Porto

et al. 2016

IJMS

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Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and treatment has been a constant challenge for basic and clinical investigators focused on translating their discoveries into clinical treatment of this complex disorder. In this review, we highlight recent experimental and clinical evidences of potential coadjuvants in the management of DM, such as polyphenols (quercetin, resveratrol and silymarin), cultured probiotic microorganisms and drugs acting through direct/indirect or pleiotropic effects on glycemic control in DM. Among several options, we highlight new promising therapeutic coadjuvants, including chemical scavengers, the probiotic kefir and the phosphodiesterase 5 inhibitors, which besides the reduction of hyperglycemia and ameliorate insulin resistance, they reduce oxidative stress and improve endothelial dysfunction in the systemic vascular circulation. In the near future, experimental studies are expected to clear the intracellular pathways involving coadjuvants. The design of clinical trials may also contribute to new strategies with coadjuvants against the harmful effects of diabetic complications.

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Cardiovascular and all-cause mortality in patients with type 2 diabetes mellitus in the MADIABETES Cohort Study: Association with chronic kidney disease

Cited by 28 publications

References 45 publications

Effects of Dulaglutide and Insulin Glargine on Estimated Glomerular Filtration Rate in a Real-world Setting

Effects of Dulaglutide and Insulin Glargine on Estimated Glomerular Filtration Rate in a Real-world Setting

Cardiovascular Risk Factors in End-Stage Renal Disease Patients: The Impact of Conventional Dialysis versus Online-Hemodiafiltration

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

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