Cardiovascular adverse events associated with oral antineoplastic therapy

Silva, Jacqueline Mota da; Lima, Beatriz da Silva; Araújo, Thelma Leite de; Lima, Francisca Elisângela Teixeira; Cunha, Gilmara Holanda da

doi:10.1590/0034-7167-2017-0450

Cited by 2 publications

(4 citation statements)

References 37 publications

(122 reference statements)

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“…Os principais agentes antitumorais, também chamados de antraciclinas, são a doxorrubicina, epirrubicina e idarrubicina, esta última sendo de uso oral e menos cardiotóxica que as intravenosas (Silva et al, 2018).…”

Section: Categoria 2 Principais Quimioterápicos Causadores De Cardiot...unclassified

“…Angina, isquemia e infarto agudo do miocárdio também foram relatados no tratamento com tamoxifeno e anastrozole (este sendo um Inibidor de Aromatase) (Silva et al, 2018).…”

Section: Categoria 2 Principais Quimioterápicos Causadores De Cardiot...unclassified

“…No tratamento com sunitinibe também foi registrada ocorrência de derrame pericárdico e nas enzimas cardíacas. Esses medicamentos também foram os mais associados às alterações na pressão arterial, o que evidenciou a grande necessidade de acompanhamento médico durante a utilização desses medicamentos (Silva et al, 2018).…”

Section: Categoria 2 Principais Quimioterápicos Causadores De Cardiot...unclassified

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The nurse's role in the care of the cardiotoxicities generated by chemotherapy administration

Teixeira¹,

Lordeiro²,

Silva³

et al. 2023

Collection of International Topics in Health Science- V1

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Cardiac toxicity is severe and an adverse effect of many chemotherapy drugs. The following guiding research question used was: how does the nurse provide health care for prevention and treatment of chemotherapy induced cardiotoxicity? This study is an Integrative Literature Review of which articles were searched in the Scielo, PubMed and BVS databases. The inclusion criteria were complete texts in Portuguese, English, and Spanish, published within a five-year period and indexed with the keywords used. The exclusion criteria were incomplete texts published over five years. The research indicates that there is a need of increasing the literary productions on the theme as well as a need of creating specific tools and guidelines to help nurses and the health care team to coordinate the care of cancer patients with cardiotoxicities generated by chemotherapeutic agents. It was also revealed that the nurse, as the only member of the health team that assists the patient in its entirety and in a holistic manner, has a crucial role in the management of risk factors, being able to act in the detection of the appearance of new signs and symptoms in the patients' routine, as well as guidance to eliminate or minimize their damage.

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Section: Categoria 2 Principais Quimioterápicos Causadores De Cardiot...unclassified

“…Angina, isquemia e infarto agudo do miocárdio também foram relatados no tratamento com tamoxifeno e anastrozole (este sendo um Inibidor de Aromatase) (Silva et al, 2018).…”

Section: Categoria 2 Principais Quimioterápicos Causadores De Cardiot...unclassified

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The nurse's role in the care of the cardiotoxicities generated by chemotherapy administration

Teixeira¹,

Lordeiro²,

Silva³

et al. 2023

Collection of International Topics in Health Science- V1

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“…It has also been used for other malignancies, including colon cancer, breast cancer, neuroendocrine cancer, and lung cancer in preclinical and clinical trials ( Demetri et al, 2006 ; Motzer et al, 2007 ). Along with the fact that cancer patients undergoing successful chemotherapy with SU often have an improved overall survival, a wide range of severe cardiac side-effects have been reported that lead to severe symptomatic heart failure in about 2% of the patients ( Gorini et al, 2018 ; Silva et al, 2018 ; Palmer et al, 2020 ). SU has a poor solubility in water, which leads to the instability of its therapeutic effects ( Alshehri and Shakeel, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Raman and fluorescence micro-spectroscopy applied for the monitoring of sunitinib-loaded porous silicon nanocontainers in cardiac cells

et al. 2022

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Nanomaterials are a central pillar in modern medicine. They are thought to optimize drug delivery, enhance therapeutic efficacy, and reduce side-effects. To foster this technology, analytical methods are needed to validate not only the localization and distribution of these nanomaterials, but also their compatibility with cells, drugs, and drug release. In the present work, we assessed nanoparticles based on porous silicon (pSiNPs) loaded with the clinically used tyrosine kinase inhibitor sunitinib for their effectiveness of drug delivery, release, and toxicity in colon cancer cells (HCT 116 cells) and cardiac myoblast cells (H9c2) using Raman micro-spectroscopy, high-resolution fluorescence microscopy, along with biological methods for toxicological effects. We produced pSiNPs with a size of about 100 nm by grinding mesoporous silicon layers. pSiNPs allowed an effective loading of sunitinib due to their high porosity. Photoluminescence properties of the nanoparticles within the visible spectrum allowed the visualization of their uptake in cardiac cells. Raman micro-spectroscopy allowed not only the detection of the uptake and distribution of pSiNPs within the cells via a characteristic silicon Raman band at about 518–520 cm−1, but also the localization of the drug based on its characteristic molecular fingerprints. Cytotoxicity studies by Western blot analyses of apoptotic marker proteins such as caspase-3, and the detection of apoptosis by subG1-positive cell fractions in HCT 116 and MTT analyses in H9c2 cells, suggest a sustained release of sunitinib from pSiNPs and delayed cytotoxicity of sunitinib in HCT 116 cells. The analyses in cardiac cells revealed that pSiNPs are well tolerated and that they may even protect from toxic effects in these cells to some extent. Analyses of the integrity of mitochondrial networks as an early indicator for apoptotic cellular effects seem to validate these observations. Our study suggests pSiNPs-based nanocontainers for efficient and safe drug delivery and Raman micro-spectroscopy as a reliable method for their detection and monitoring. Thus, the herein presented nanocontainers and analytical methods have the potential to allow an efficient advancement of nanoparticles for targeted and sustained intracellular drug release that is of need, e.g., in chronic diseases and for the prevention of cardiac toxicity.

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Cardiovascular adverse events associated with oral antineoplastic therapy

Cited by 2 publications

References 37 publications

The nurse's role in the care of the cardiotoxicities generated by chemotherapy administration

The nurse's role in the care of the cardiotoxicities generated by chemotherapy administration

Raman and fluorescence micro-spectroscopy applied for the monitoring of sunitinib-loaded porous silicon nanocontainers in cardiac cells

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