Cardiovascular actions of substituted adenosine analogues

Angus, James A.; Cobbin, L. B.; Einstein, Rosemarie; Maguire, M. Helen

doi:10.1111/j.1476-5381.1971.tb07067.x

Cited by 33 publications

(5 citation statements)

References 14 publications

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“…Among them N 6 -chlorocyclopentyladenosine (CCPA) and N 6 -cyclopentyladenosine (CPA) have been reported as being highly selective A 1 AR agonists. 4 On the other hand, reported AR antagonists are usually derivatives of xanthines such as caffeine or theophylline. 5 Thus, having drugs that modulate A 1 AR at one's disposal could be interesting in different therapeutic areas, including heart failure, diuresis, 6 heart arrhythmia, 7 glucose tolerance, 8 cognitive diseases 9 and contrast media-induced acute renal failure.…”

Section: Introductionmentioning

confidence: 99%

Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

Mathew

Berthault

et al. 2010

Org. Biomol. Chem.

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Section: Introductionmentioning

confidence: 99%

Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

Mathew

Berthault

et al. 2010

Org. Biomol. Chem.

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“…Adenosine and its metabolically stable analogs can have pronounced cardiovascular effects as well, producing dose-related decreases in blood pressure and heart rate in monkeys (Coffin and Spealman 1987) as well as other species (Thorp and Cobbin 1959;Angus et al 1971;Vapaatalo et al 1975;Olsson et al 1979;Barraco et al 1984;Ohnishi et al 1986). A major factor contributing to the hypotensive effects of these drugs appears to be their vasodilating actions on peripheral vessels (Angus et al 1971;Einstein et al 1972).…”

Section: Role Of Adenosine Receptor Antagonism and Pde Inhibitionmentioning

confidence: 95%

“…A major factor contributing to the hypotensive effects of these drugs appears to be their vasodilating actions on peripheral vessels (Angus et al 1971;Einstein et al 1972). Coronary arteries also are sensitive to the vasodilatory effects of adenosine analogs, and the observed potency relations suggest that these actions are mediated primarily at adenosine A 2 receptors (Kusachi et al 1983;Haleen and Evans 1985).…”

Section: Role Of Adenosine Receptor Antagonism and Pde Inhibitionmentioning

confidence: 96%

Behavioral and physiological effects of xanthines in nonhuman primates

Howell

Coffin²,

Spealman

1997

Psychopharmacology

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Caffeine and related xanthines can have significant behavioral effects on measures of locomotor activity, schedule-controlled behavior, drug self-administration, and learning and memory. Xanthines also produce numerous physiological effects including positive inotropic and chronotropic effects on the heart, decreased airway resistance in the lung, and respiratory stimulation. Due to the widespread use of xanthines as constituents of food and beverages and as therapeutic drugs, identification of mechanisms that mediate their pharmacological effects has considerable relevance for drug development and therapeutics. Two primary mechanisms involving the cyclic nucleotide system have been implicated as the bases for the effects of xanthines in the CNS. Many xanthines bind to specific adenosine recognition sites and block the actions of adenosine. Xanthines also inhibit cyclic nucleotide phosphodiesterases, the enzymes responsible for the hydrolytic inactivation of cyclic AMP and cyclic GMP. Recent research in nonhuman primates has characterized the behavioral, respiratory and cardiovascular effects of a number of xanthines and related drugs differing in affinity at different subtypes of adenosine receptors and in capacity to inhibit different molecular forms of PDE. The behavioral-stimulant effects of xanthines appear to be mediated principally by their adenosine-antagonist actions and may be limited by PDE inhibition. The respiratory-stimulant and cardiac effects of xanthines, on the other hand, appear to be linked more closely to their PDE-inhibiting actions than to adenosine antagonism. Converging lines of evidence suggest that adenosine A2 and cAMP-specific (possibly type IV) PDE mechanisms play especially prominent roles in mediating the behavioral and physiological effects of xanthines in nonhuman primates.

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“…Since the cardiovascular actions of adenosine were first described by Drury & Szent-Gyorgyi in 1929, many analogues have been synthesized in attempts to improve and prolong these actions (Clarke et al, 1952;Dietmann, Birkenheier & Schaumann, 1970;Angus et al, 1971 ;Kawazoe & Kikuchi, 1974;Cobbin, Einstein & Maguire, 1974;Raberger, Schutz & Kraupp, 1977).…”

Section: Introductionmentioning

confidence: 99%

The Cardiovascular Actions of 1‐methylisoguanosine

Marwood¹

1981

Clin Exp Pharma Physio

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1. 1-Methylisoguanosine was found to cause a potent long-lasting decrease in both blood pressure and heart rate after oral administration to conscious hypertensive rats. Dose-response curves to intravenously administered 1-methylisoguanosine and adenosine in anaesthetized rats demonstrated qualitatively similar decreases in blood pressure and heart rate, with 1-methylisoguanosine being two to three times more potent than adenosine. 2. In guinea-pig isolated atria, 1-methylisoguanosine exhibited a negative inotropic and a negative chronotropic effect with a greater potency than adenosine. 3. In halothane-anaesthetized cats, 1-methylisoguanosine produced a biphasic response on cardiac output: a rapid initial decrease followed by a slow increase. 4. 1-Methylisoguanosine had no effect on the response to intralumenally administered noradrenaline in isolated perfused rat tail arteries but reduced the response to electrical stimulation. In these effects, 1-methylisoguanosine was similar to adenosine.

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Cardiovascular actions of substituted adenosine analogues

Cited by 33 publications

References 14 publications

Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

Behavioral and physiological effects of xanthines in nonhuman primates

The Cardiovascular Actions of 1‐methylisoguanosine

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