Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant

Aguilar-Melero, Patricia; Luque, Antonio; Machuca, M.M. Granados; Obanos, María P. Pérez de; Navarrete, Rocío; Rodríguez-García, Inés C.; Briceño, Javier; Íñiguez, María; Ruiz, Juan; Prieto, Jesús; Mata, Manuel de la; Gómez-Villamandos, R.J.; Muntané, Jordi; López‐Cillero, Pedro

doi:10.1016/j.jss.2012.07.046

Cited by 30 publications

(19 citation statements)

References 34 publications

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“…CT-1 enhanced regeneration of cirrhotic livers through promotion of angiogenesis and cell proliferation [97]. Furthermore, the administration of CT-1 to donors decreased ischemia/reperfusion damage in liver transplantation in an experimental pig model [98]. Finally, the administration of adenovirus encoding CT-1 improved liver function and the survival of small-for-size grafts [99].…”

Section: Livermentioning

confidence: 99%

See 1 more Smart Citation

Cardiotrophin-1: A multifaceted cytokine

López-Yoldi

Moreno-Aliaga

Bustos

2015

Cytokine & Growth Factor Reviews

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Section: Livermentioning

confidence: 99%

“…Indeed, it was found that CT-1 lowered TNF-a levels in a model of endotoxemia [115], in orthotopic liver transplant [98], in obese mice [100] and in renal ischemia/reperfusion injury [116]. Also, rCT-1 administration prevented the renal toxicity of iodinated contrast media in rats [117].…”

Section: Inflammationmentioning

confidence: 99%

Cardiotrophin-1: A multifaceted cytokine

López-Yoldi

Moreno-Aliaga

Bustos

2015

Cytokine & Growth Factor Reviews

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“…In the ischemic state, both TSP‐1 and CD47 are up‐regulated and linked with ROS induction in vascular cells, and this leads to inflammatory reactions, endothelial cell injury accompanied by microcirculatory dysfunction, and extensive tissue necrosis . Hence, we postulate that CD47 blockade using antibodies specific to CD47 (CD47mAbs) will provide cytoprotection against IRI during liver transplantation.…”

mentioning

confidence: 99%

CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model

et al. 2015

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Orthotopic liver transplantation (OLT) remains the standard treatment option for nonresponsive liver failure. Because ischemia/reperfusion injury (IRI) is an important impediment to the success of OLT, new therapeutic strategies are needed to reduce IRI. We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Syngeneic OLT was performed with Lewis rats. Control immunoglobulin G or CD47mAb400 was administered to the donor organ at procurement or to both the organ and the recipient at the time of transplant. Serum transaminases, histological changes of the liver, and animal survival were assessed. Oxidative stress, inflammatory responses, and hepatocellular damage were also quantified. A significant survival benefit was not achieved when CD47mAb400 was administered to the donor alone. However, CD47mAb400 administration to both the donor and the recipient increased animal survival afterward. The CD47mAb400-treated group showed lower serum transaminases, bilirubin, oxidative stress, terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling staining, caspase-3 activity, and proinflammatory cytokine expression of tumor necrosis factor α, interleukin-1β, and interleukin-6. Thus, CD47 blockade with CD47mAb400 administered both to the donor and the recipient reduced liver graft IRI in a rat liver transplantation model. This may translate to decreased liver dysfunction and increased survival of liver transplant recipients.

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“…The lowest level of MPO was observed in the HPIR and control groups in our study. CT-1 is a member of a family of cytokines that has been demonstrated to have cytoprotective properties against I/R injury (32). The results of our experiments indicate that montelukast and H. perforatum treatment reduced some of the ischemia-induced damage and increased CT-1 levels in hamster intestines.…”

Section: Discussionmentioning

confidence: 51%