Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system

Gard, Anthony L.; Gavin, Elaine; Solodushko, Viktoriya; Pennica, Diane

doi:10.1016/j.neuroscience.2004.03.065

Cited by 22 publications

(16 citation statements)

References 77 publications

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“…Review ependyma. This fi nding has broad implications for CT-1 functioning apart from other leukemia inhibitory factor receptor ligands as a CSF-borne signal of brain homeostasis, one possibly involving regulation of the barrier itself, the ependyma or target cells in the surrounding parenchyma, including the subventricular zone 85 . CT-1 is expressed at high levels in embryonic limb bud and is secreted by diff erentiated myotubes.…”

Section: Cancermentioning

confidence: 93%

Cardiotrophin-1 Review

Stejskal¹,

Růžička²

2008

BIOMED PAP

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Section: Cancermentioning

confidence: 93%

Cardiotrophin-1 Review

Stejskal¹,

Růžička²

2008

BIOMED PAP

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“…6E). The choroid plexus generates the cerebrospinal fluid (CSF) that bathes the interior of the embryonic and adult brain, and it is known to secrete many different growth factors and cytokines (Chodobski and Szmydynger-Chodobska, 2001;Dziegielewska et al, 2001;Gard et al, 2004;Speake et al, 2001;Sturrock, 1979). Our results suggest that the embryonic choroid plexus also generates CNTF and LIF.…”

Section: Cntf/lif/gp130 Signaling Is Required In Vivo To Maintain Thementioning

confidence: 99%

“…It has been suggested that the adult choroid plexus does not express CNTF and LIF (Gard et al, 2004), which may be significant given that only the SVZ (and not the VZ) is maintained into adulthood. Perhaps the production of CNTF and LIF by the choroid plexus is required to maintain levels of these molecules sufficient for the formation of both the VZ and SVZ germinal layers.…”

Section: Cntf/lif/gp130 Signaling Maintains a Gradient Of Vz Precursomentioning

confidence: 99%

CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain

Gregg

Weiss

2005

Development

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The extrinsic signaling pathways responsible for the formation and maintenance of the unique laminar organization of the forebrain germinal zones are largely unknown. In the present study, we asked whether ciliary neurotrophic factor (CNTF)/leukemia inhibitory factor (LIF)/gp130 signaling plays a role in the development of the germinal layers in the lateral ganglionic eminence. We found that CNTF/LIF/gp130 receptor signaling promotes the self-renewal/expansion of a subpopulation of fibroblast growth factor-responsive ventricular zone (VZ) precursors in the ventral forebrain. Analysis of Lifr-/- mice suggests that CNTF/LIF/gp130 signaling maintains a subpopulation of GSH2+ VZ precursors, which are necessary for normal growth of the early ventral forebrain and for maintaining a gradient of VZ precursor differentiation in the lateral ganglionic eminence,as defined by GSH2, MASH1 and DLX2 expression. Furthermore, addition of exogenous CNTF to embryonic forebrain explant cultures deprived of choroid plexus-derived CNTF, was sufficient to promote a VZ differentiation gradient. In contrast to the forebrain, CNTF/LIF/gp130 signaling reduced, rather than enhanced, precursor self-renewal/expansion in the spinal cord. These results demonstrate a novel region-specific role for CNTF/LIF/gp130 signaling in the development of the germinal layers of the embryonic telencephalon.

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“…Bidirectional inward and outward transport occurs at all interfaces depicted; however, this review emphasizes transport of substances into the brain. (21,24,30,38,68) Ependyma LV, 3V, 4V Leaky c Single Allows the CSF Bsink action^on the brain due to high permeability (11,56,57,59,61,62) CVOs 3V, 4V Tight Single Integrates hormonal and neural activity to effect fluid homeostasis (2,38,75,76,111) PiaYglia SAS d Leaky Multiple Protects brain by filtering and buffering actions on SAS CSF (3,148,149) Arachnoid SAS Tight Multiple Secretes neurotrophic peptides and reabsorbs CSF in the villi (1Y3, 34,40,127,129) a Virtually all epithelia in the CSF system can metabolize drugs. b LV, 3V, and 4V refer to the lateral, third, and fourth ventricles, respectively.…”

Section: Choroidal Blood Flow and Interstitial Fluid Dynamicsmentioning

confidence: 99%

“…Ependymal cell receptor stimulation leads to a plethora of homeostatic activities. As an integral part of homeostatic responses, the ependyma help to mediate effects of growth factors (56), neuropeptides (57), proteins (58), cytokines (59), and hormones (60). These diverse modulatory actions benefit the neurons and glia.…”

Section: Ependymamentioning

confidence: 99%

Enhanced Prospects for Drug Delivery and Brain Targeting by the Choroid Plexus–CSF Route

et al. 2005

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The choroid plexus (CP), i.e., the blood-cerebrospinal fluid barrier (BCSFB) interface, is an epithelial boundary exploitable for drug delivery to brain. Agents transported from blood to lateral ventricles are convected by CSF volume transmission (bulk flow) to many periventricular targets. These include the caudate, hippocampus, specialized circumventricular organs, hypothalamus, and the downstream pia-glia and arachnoid membranes. The CSF circulatory system normally provides micronutrients, neurotrophins, hormones, neuropeptides, and growth factors extensively to neuronal networks. Therefore, drugs directed to CSF can modulate a variety of endocrine, immunologic, and behavioral phenomema; and can help to restore brain interstitial and cellular homeostasis disrupted by disease and trauma. This review integrates information from animal models that demonstrates marked physiologic effects of substances introduced into the ventricular system. It also recapitulates how pharmacologic agents administered into the CSF system prevent disease or enhance the brain's ability to recover from chemical and physical insults. In regard to drug distribution in the CNS, the BCSFB interaction with the blood-brain barrier is discussed. With a view toward translational CSF pharmacotherapy, there are several promising innovations in progress: bone marrow cell infusions, CP encapsulation and transplants, neural stem cell augmentation, phage display of peptide ligands for CP epithelium, CSF gene transfer, regulation of leukocyte and cytokine trafficking at the BCSFB, and the purification of neurotoxic CSF in degenerative states. The progressively increasing pharmacological significance of the CP-CSF nexus is analyzed in light of treating AIDS, multiple sclerosis, stroke, hydrocephalus, and Alzheimer's disease.

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Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system

Cited by 22 publications

References 77 publications

Cardiotrophin-1 Review

Cardiotrophin-1 Review

CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain

Enhanced Prospects for Drug Delivery and Brain Targeting by the Choroid Plexus–CSF Route

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