Cardiotoxicity of verapamil in renal failure: a case report and review of the literature

Abstract

We present a case of a 76-year-old diabetic patient on verapamil with undiagnosed renal failure presenting with collapse and severe life threatening bradyarrhythmias. She responded well to inotropic support and calcium supplementation.

Guizhi Fuling Wan, a Traditional Chinese Herbal Formula, Sensitizes Cisplatin‐Resistant Human Ovarian Cancer Cells through Inactivation of the PI3K/AKT/mTOR Pathway

“…administration in mouse was reported to be 7.6 mg·kg −1 [ 39 ], a single i.v. dose of 2.5 mg·kg −1 VER still caused the death of 40% of animals in the in vivo efficacy test, which may result from the cardiotoxicity of VER [ 40 ]; instead, no mice died in the combinative treatment of cisplatin, paclitaxel, and LD of GFW group. These data suggest, for the first time, that GFW may be an efficacious reversal TCM formula for ovarian cancer in vitro and in vivo .…”

Short-term exposure to L-type calcium channel blocker, verapamil, alters the expression pattern of calcium-binding proteins in the brain of goldfish, Carassius auratus

“…High doses of VRP show cardiovascular toxicity in human patients suffering from mostly renal failure (Ashraf et al, 1995;Batalis et al, 2007;Jadhav and Bohra, 2009), primarily due to inefficiency of the renal system to excrete unmetabolized VRP and its metabolites (Váquez et al, 1996). Effects of VRP overdose are evident not only in the cardiovascular system but are reported also on pancreatic cells resulting in hyperglycemia (Levine et al, 2007).…”