Cardiotoxicity: Cisplatin and long-term cancer survivors

Insights into cardio-oncology: adrenergic receptor signaling and pathways in breast cancer.

“…Nowadays cardiotoxicity prevention still remains an important challenge along with its surveillance and management in cancer survivors [2][3][4][5] . Research has emphasized both cardioprotective beta adrenergic receptor blocker (BB) use against cardiotoxic chemiotherapies [2][3][4][5] and the activation of the sympathetic nervous system as a target for regulation of breast cancer, and it has also suggested a possible role for targeted breast cancer therapy using BBs 6,7 .…”

“…Nowadays cardiotoxicity prevention still remains an important challenge along with its surveillance and management in cancer survivors [2][3][4][5] . Research has emphasized both cardioprotective beta adrenergic receptor blocker (BB) use against cardiotoxic chemiotherapies [2][3][4][5] and the activation of the sympathetic nervous system as a target for regulation of breast cancer, and it has also suggested a possible role for targeted breast cancer therapy using BBs 6,7 . Although research has confirmed continuous use of BBs as being associated with cardioprotective lower incidence of heart failure 5,8 and with reducing related psychological distress 9 in patients with breast cancer, there is retrospective evidence suggesting that the use of BBs in early stage breast cancer patients correlates with an increased time to recurrence 2,10 .…”

Cisplatin induced arrhythmia; electrolyte imbalance or disturbance of the SA node?

“…However, over the past decade there has been a surge in the amount of clinical cases reporting a vast array of cardio-toxic events occurring during or shortly after cisplatin infusion (Patane, 2014;El-Awady et al, 2011). These include silent and symptomatic arrhythmias, angina, myocarditis, pericarditis, diastolic disturbances, cardiac ischemia, acute myocardial infarction, thromboembolic events, and chronic heart failure (CHF).…”

“…These include silent and symptomatic arrhythmias, angina, myocarditis, pericarditis, diastolic disturbances, cardiac ischemia, acute myocardial infarction, thromboembolic events, and chronic heart failure (CHF). The mechanisms of 3 action of cisplatin's cardiotoxic activity is still unknown and yet to be identified (Patane, 2014;El-Awady et al, 2011).…”

The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart

“…Many preclinical and clinical researchers have suggested that chronic cisplatin therapy is associated with severe side effect such as cardiotoxicity (10,11). Cardiotoxicity may be an early or late complication after treatment with cisplatin.…”