Abstract:AIMS Doxorubicin-induced cardiotoxicity (DIC) is a significant cause of
mortality in cancer care. This study was conducted to establish the
frequency of DIC in Zimbabwean breast cancer patients on doxorubicin and
to test the DIC predictive power of genetic biomarkers. METHODS A cohort
of 50 Zimbabwean breast cancer patients treated with doxorubicin were
followed up for 12 months with serial echocardiography and genotyped for
UGTA1A6*4, SLC28A3 and RARG. 11% of the patients experienced DIC.
RESULTS The frequenc… Show more
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