Cardiotonic Principles of Ginger (Zingiber officinale Roscoe)

Shoji, Noboru; Iwasa, A.; Takemoto, Tsunematsu; Ishida, Yusuke; Ohizumi, Yasushi

doi:10.1002/jps.2600711025

Cited by 114 publications

(63 citation statements)

References 4 publications

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“…Ginger is one of the most important spices throughout the world, its tuber having been utilized for treating headache, nausea, stomach ache, and colds as a traditional medicine and having also been used as a stimulant. 6) It has also been shown to possess antioxidative properties, and there have been a few reports on its chemical constituents; 7,8) however, there have been no reports on the antifouling activity of its constituents. In this paper, we report the isolation of attachmentinhibitors from the hexane fraction of the roots of ginger, Z. o‹cinale.…”

Section: -5)mentioning

confidence: 99%

Shogaols from Zingiber officinale as Promising Antifouling Agents

Etoh

Kondoh

Noda

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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Section: -5)mentioning

confidence: 99%

Shogaols from Zingiber officinale as Promising Antifouling Agents

Etoh

Kondoh

Noda

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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“…The pharmacological properties of gingerols include antioxidant, analgesic and anti-inflammatory [6] , antipyretic [7] , cardiotonic [8] , and hypothermic [9] activities. More recent studies have suggested that gingerols exhibit preventive activity against cancers of the skin [10] , pancreas [11] , gastrointestinal tract [12] , colon [13] , and breast [14] .…”

Section: Introductionmentioning

confidence: 99%

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Chen

Yue

et al. 2013

Acta Pharmacol Sin

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Aim: Ginger rhizome is used worldwide as a spicy flavor agent. This study was designed to explore the potential effects of pungent ginger components, 6-, 8-, and 10-gingerol, on human cytochrome P450 (CYP450) enzymes that are responsible for the metabolism of many prescription drugs. Methods: The activities of human CYP2C9, CYP2C19, CYP2D6, and CYP3A4 were analyzed using Vivid P450 assay kits. The mRNA expression of CYP3A4 in human hepatocellular carcinoma cell line HepG2 was measured using quantitative real-time PCR assay. Results: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6. 8-Gingerol was the most potent in inhibition of P450 enzymes with IC 50 values of 6.8, 12.5, 8.7, and 42.7 μmol/L for CYP2C9, CYP2C19, CYP3A4, and CYP2D6, respectively. By comparing the effects of gingerols on CYP3A4 with three different fluorescent substrate probes, it was demonstrated that the inhibition of gingerols on CYP3A4 had no substrate-dependence. In HepG2 cells, 8-gingerol and 10-gingerol inhibited, but 6-gingerol induced mRNA expression of CYP3A4. Conclusion: 6-, 8-, and 10-gingerol suppress human cytochrome P450 activity, while 8-and 10-gingerol inhibit CYP3A4 expression. The results may have an implication for the use of ginger or ginger products when combined with therapeutic drugs that are metabolized by cytochrome P450 enzymes.

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“…The chemical structure of the diaryl heptanoids used in the present study have the same length of alkyl chain as (*)- [4] gingerol. The substitution of the hydrogen at the C-7 position with a phenyl group (com pound A, (±)-yakuchinone-A and (±)-HHC) significantly suppressed the spontaneous Ca 21 spikes and contraction, whereas (±) [4] gingerol had weak effects.…”

Section: Discussionmentioning

confidence: 99%

“…The substitution of the hydrogen at the C-7 position with a phenyl group (com pound A, (±)-yakuchinone-A and (±)-HHC) significantly suppressed the spontaneous Ca 21 spikes and contraction, whereas (±) [4] gingerol had weak effects. The introduction of the free OH group in the phenyl moieties (compound A to compound B) also reduced the inhibitory activity.…”

Section: Discussionmentioning

confidence: 99%