Abstract:Isomazole analogues which have achiral electron withdrawing substituents at the 4'-position and analogues with heterocyclic 'C' rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the 'C' ring without loss of activity. The 4'-methylsulphonyl, -cyano, -carboxamido, and acetyl analogues had similar inotropic potencies to Isomazole whilst displaying superior cardiovascular profiles in in vivo studies.
The 2‐methoxybenzoic acids (VI) and (XI), prepared as outlined in the reaction scheme, are coupled with the diaminopyridine (VII) to form the corresponding imidazopyridines (VIII) and (XIII).
The 2‐methoxybenzoic acids (VI) and (XI), prepared as outlined in the reaction scheme, are coupled with the diaminopyridine (VII) to form the corresponding imidazopyridines (VIII) and (XIII).
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