Cardiothoracic Morphology Measures in Heart Failure Patients to Inform Device Designs

Saffarzadeh, Mona; Gaewsky, James P; Tan, Joshua C.; Lahm, Ryan; Upadhya, Bharathi; Jao, Geoffrey T.; Weaver, Ashley A.

doi:10.1007/s13239-019-00436-z

Cited by 4 publications

(6 citation statements)

References 23 publications

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“…Patients with reduced EF revealed an increased LV long-axis length and an increased angle between the MV and LV long-axis. 1 Developing a transapical-to-aorta intracardiac LVAD, Liu et al analyzed a larger cohort (N = 199), including 21 HF patients by echocardiography. The range of the end-diastolic distance between apex and AV (72.6-116.0 mm) was comparable to the range found among Controls in our study.…”

Section: Discussionmentioning

confidence: 99%

“…collected twelve cardiothoracic measurements from CTA scans in a small cohort ( N = 20). Patients with reduced EF revealed an increased LV long‐axis length and an increased angle between the MV and LV long‐axis 1 . Developing a transapical‐to‐aorta intracardiac LVAD, Liu et al.…”

Section: Discussionmentioning

confidence: 99%

“…These dimensions are, however, essential for the design of novel devices and their implantation. 1 Facing an increasing HF prevalence, a donor shortage for heart transplantation, and a lack of approved biological alternatives, left ventricular assist devices (LVAD) are considered indispensable. New surgical techniques and novel MCS devices are required to improve patient outcomes and reduce device-related adverse events.…”

Section: Introductionmentioning

confidence: 99%

“…While echocardiography allows an incomplete depiction of the longitudinal dimensions, computed tomography angiography (CTA), unlike MRI, can be obtained before and after LVAD implantation, providing excellent spatial-temporal resolution. 1 In this study, we aimed to investigate the longitudinal cardiac dimensions in patients undergoing LVAD implantation from CTA. We further aimed to correlate these dimensions to patient characteristics and quantify their alterations after LVAD implantation.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to LV diameters, volumes, and function, little is known about the longitudinal dimensions (e.g., distance between apex and aortic valve, AV) and their alterations among HF and MCS patients. These dimensions are, however, essential for the design of novel devices and their implantation 1 …”

Section: Introductionmentioning

confidence: 99%

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Longitudinal cardiac dimensions in patients undergoing LVAD implantation

Meissner,

Szvetics,

Galbas

et al. 2024

Artificial Organs

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BackgroundIn conventional left ventricular assist devices (LVAD), a separate outflow graft is sutured to the ascending aorta. Novel device designs may include a transventricular outflow cannula crossing the aortic valve (AV). While transversal ventricular dimensions are well investigated in patients with severe heart failure, little is known about the longitudinal dimensions. These dimensions are, however, particularly critical for the design and development of mechanical circulatory support (MCS) devices with transaortic outflow cannula.MethodsIn an explorative retrospective cohort study at the University Medical Center Freiburg, Germany, the longitudinal cardiac dimensions of patients undergoing computed tomography angiography (CTA) before and, if available, after LVAD implantation were analyzed. Among others, the following dimensions were assessed: (a) apex to AV, (b) apex to mitral valve, (c) AV to sinotubular junction (STJ), (d) apex to STJ, (e) apex to brachiocephalic artery (BCA), and (f) AV to BCA.ResultsIn total, 44 LVAD patients (36 male, age 55.8 years, height 1.75 m) were included. The longitudinal cardiac dimensions were (a) 114.5 ± 12.1 mm, (b) 108.0 ± 12.4 mm, (c) 20.9 ± 2.9, (d) 135.4 ± 13.4 mm, (e) 206.0 ± 18.3, and (f) 91.5 ± 9.8 mm. Postoperatively, (a) and (b) decreased by 31.5% and 39.5%, respectively (N = 14).ConclusionsLongitudinal cardiac dimensions may be reduced by up to 40% after LVAD implantation. A better knowledge of these dimensions and their postoperative alterations in LVAD patients may improve surgical planning and help to design MCS devices with transventricular outflow cannula.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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