Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE)

Huang, Jing; Song, Yi; Chu, Mengtian; Dong, Wei; Miller, Mark R.; Loh, Miranda; Xu, Jianfeng; Yang, Di; Chi, Rui; Yang, Xuan; Wu, Shaowei; Guo, Xinbiao; Deng, Furong

doi:10.1016/j.envint.2019.105021

Cited by 39 publications

(22 citation statements)

References 48 publications

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“… 6 , 7 While our recent study suggested that short-term exposure to ozone (8.7 ± 6.6 ppb) indoors was associated with reduced cardiac autonomic and pulmonary function and increased fractional exhaled nitric oxide (FeNO) among children, its associations with pulmonary function and FeNO were not significant (p > 0.05). 8 In accordance with our findings, one previous study also found that indoor ozone exposure of <10 ppb was not associated with lung function changes, while it was associated with platelet activation and blood pressure (BP) increase, 4 which suggests that indoor exposure to ozone at relatively low concentrations (compared with the current standard limits and ranges of ozone concentrations in the studies conducted in the last decade; Tables S1 and S2 ) may possibly affect cardiovascular health. However, the exact mechanisms underlying the cardiorespiratory effects of ozone exposure remain uncertain.…”

Section: Introductionsupporting

confidence: 89%

Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children: A Repeated-Measure Panel Study

et al. 2021

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Ozone is one of the major gaseous pollutants associated with short-term adverse cardiopulmonary effects, even at concentrations below the current indoor air quality limits. However, the underlying biological mechanisms of cardiorespiratory changes with exposure to ozone remain unclear. To further explore molecular linkages between indoor ozone exposure and relevant cardiorespiratory effects, a repeated-measure panel study including 46 schoolchildren was conducted and real-time exposure measurements including ozone were performed inside classrooms every weekday during the study period. Repeated health measurements and urine sample collection were conducted in each participant. Ultra-high-performance liquid chromatography/tandem mass spectrometry and meet-in-metabolite approach were used in metabolomics analysis. Methods including mixed-effect models were adopted to identify metabolites associated with ozone exposure or health indices. Nine metabolites were found to be associated with ozone after mixed-effect model analysis, which are mainly involved in amino acid and bile acid metabolism. Boys may have a greater decrease in bile acid and RNA related metabolites. Four of the nine ozone-related metabolites were also associated with cardiorespiratory function indices. Furthermore, 26.67% of the positive association between ozone and heart rate was mediated by cholestane-3,7,12,25-tetrol-3-glucuronide. Exposure to ozone below the current indoor standards was associated with the deteriorated cardiovascular function by disturbing bile acid and endogenous nitric oxide-related oxidation and inflammation, and associated with the exacerbated airway inflammation by reducing GPx-related anti-oxidation. The results provide metabolic evidence of the cardiorespiratory effects of indoor ozone exposure. Indoor ozone pollution should be controlled further, and more attention should be paid to preventing its adverse health effects, especially in children.

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Section: Introductionsupporting

confidence: 89%

Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children: A Repeated-Measure Panel Study

et al. 2021

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“…NMHC is measured by gas sensitive semiconductor (GSS) sensor [20,21]. The literature has revealed that these sensors are reliable and they have been used by several studies [18,19,[22][23][24][25][26][27][28]. The sampling point height in each spot and for each pollutant was designated to match the human respiratory height (between 1.3-1.6 m).…”

Section: On-site Measurementsmentioning

confidence: 99%

Evaluation of the Indoor Air Quality in Governmental Oversight Supermarkets (Co-Ops) in Kuwait

Almutairi¹,

Alsanad²,

Alhelailah³

2019

Applied Sciences

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Examining the indoor air environment of public venues, especially populated supermarkets such as Co-Ops in Kuwait, is crucial to ensure that these venues are safe from indoor environmental deficits such as sick building syndrome (SBS). The aim of this study was to characterize the quality of the indoor air environment of the Co-Ops supermarkets in Kuwait based on investigation of CO2, CO, NO2, H2S, TVOCs, and NMHC. On-site measurements were conducted to evaluate these parameters in three locations at the selected Co-Ops, and the perceived air quality (PAQ) was determined to quantify the air’s pollutants as perceived by humans. Moreover, the indoor air quality index (AQI) was constructed for the selected locations, and the ANOVA test was used to analyze the association between the observed concentrations among these environmental parameters. At least in one spot at each Co-Op, the tested environmental parameters exceeded the threshold limit set by the environmental agencies. The PAQ for Co-Op1, 2, and 3 are 1.25, 1.00, and 0.75 respectively. CO2 was significantly found in an association with CO, H2S, and TVOCs, and its indoor-outdoor concentrations were significantly correlated with R2 values ranges from 0.40 to 0.86 depending on the tested location.

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“…Ozone is also associated with increased hospital admissions (12). Huang et al suggested that indoor ozone <10 ppb was associated with cardiovascular responses in children (13). The impact of indoor exposure to particulate matter on health depends on the particle size, with particle sizes <1 µm having the greatest impact (14).…”

Section: Introductionmentioning

confidence: 99%

Study of the Characteristics and Comprehensive Fuzzy Assessment of Indoor Air Chemical Contamination in Public Buildings

Liang

Zhang

et al. 2021

Front. Public Health

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Quality-of-life is improving daily with continuous improvements in urban modernization, which necessitates more stringent requirements for indoor air quality. Fuzzy assessment enables us to obtain the grade of the evaluation object by compound calculation with the help of membership function and weight coefficient, overcoming the limitations of traditional methods applied to develop environmental quality indices. First, this study continuously measured SO2, O3, NO2, NO, CO, CO2, PM10, PM2.5, and other chemical pollutants during the daytime operating hours of a library and a canteen. We analyzed the concentration distributions of the particles in the air were discussed based on 31 different particle diameters. Finally, the experimental data in department store and waiting hall were analyzed by fuzzy evaluation, with the following results. (1) The library and canteen PM10 concentrations peaked at 07:45 in the morning and was elevated during the afternoon (48.9 and 59 μg/m3, respectively). (2) The Pearson correlation coefficient of the PM10 and PM2.5 concentrations in the library was 0.98. PM10 and SO2 in the canteen were negatively correlated, with a correlation coefficient of −0.65. PM2.5 and PM1 were always highly positively correlated. (3) The high concentration of particles in the library was associated with the small particle size range (0.25~0.45 μm). (4) By applying the fuzzy comprehensive evaluation method, the library grade evaluation was the highest level, and the waiting hall was the lowest. This study enhances our understanding of the indoor chemical contamination relationships for public buildings and highlights the urgent need for improving indoor air quality.

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Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE)

Cited by 39 publications

References 48 publications

Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children: A Repeated-Measure Panel Study

Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children: A Repeated-Measure Panel Study

Evaluation of the Indoor Air Quality in Governmental Oversight Supermarkets (Co-Ops) in Kuwait

Study of the Characteristics and Comprehensive Fuzzy Assessment of Indoor Air Chemical Contamination in Public Buildings

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