Cardiorespiratory neurons of the rat ventrolateral medulla contain TASK-1 and TASK-3 channel mRNA

Washburn, Christopher P.; Bayliss, Douglas A.; Guyenet, Patrice G.

doi:10.1016/s1569-9048(03)00185-x

Cited by 47 publications

(49 citation statements)

References 47 publications

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“…Expression of TASK channel transcripts is widespread throughout the CNS (Karschin et al, 2001;Talley et al, 2001;Vega-Saenz et al, 2001), and it is now clear that TASK-like background K ϩ currents contribute to regulation of excitability in numerous cell types (Millar et al, 2000;Sirois et al, 2000;Han et al, 2003;Meuth et al, 2003Meuth et al, , 2006Berg et al, 2004;Aller et al, 2005;Taverna et al, 2005;Burdakov et al, 2006;Torborg et al, 2006;Brickley et al, 2007), including many central respiratory-related neurons Washburn et al, 2002Washburn et al, , 2003. In addition, it has been proposed that TASK channels may be involved in regulation of respiration by peripheral chemoreceptors (e.g., via hypoxic inhibition of TASK-like channels in carotid body glomus cells) (Buckler, 2007).…”

Section: Task Channel Contributions To Respirationmentioning

confidence: 99%

“…These channels contribute to background K ϩ currents and are highly sensitive to physiological shifts in pH (Lesage, 2003;Talley et al, 2003). We showed that a number of different neuron types in the respiratory network express TASK channels that can impart intrinsic chemosensitivity to cells in which they are expressed Talley et al, 2000;Washburn et al, 2002Washburn et al, , 2003.…”

Section: Introductionmentioning

confidence: 96%

“…In previous work, we and others have proposed that the tandem pore-domain K ϩ channels TASK-1 and TASK-3 (K 2P 3.1 and K 2P 9.1) serve as molecular substrates for central chemoreception Washburn et al, 2002Washburn et al, , 2003Feldman et al, 2003;Lesage, 2003;Talley et al, 2003;Mulkey et al, 2004;Putnam et al, 2004). These channels contribute to background K ϩ currents and are highly sensitive to physiological shifts in pH (Lesage, 2003;Talley et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity

Mulkey¹,

Talley²,

Stornetta³

et al. 2007

J. Neurosci.

171

250

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Central respiratory chemoreception is the mechanism by which the CNS maintains physiologically appropriate pH and PCO 2 via control of breathing. A prominent hypothesis holds that neural substrates for this process are distributed widely in the respiratory network, especially because many neurons that make up this network are chemosensitive in vitro. We and others have proposed that TASK channels (TASK-1, K 2P 3.1 and/or TASK-3, K 2P 9.1) may serve as molecular sensors for central chemoreception because they are highly expressed in multiple neuronal populations in the respiratory pathway and contribute to their pH sensitivity in vitro. To test this hypothesis, we examined the chemosensitivity of two prime candidate chemoreceptor neurons in vitro and tested ventilatory responses to CO 2 using TASK channel knock-out mice. The pH sensitivity of serotonergic raphe neurons was abolished in TASK channel knock-outs. In contrast, pH sensitivity of neurons in the mouse retrotrapezoid nucleus (RTN) was fully maintained in a TASK null background, and pharmacological evidence indicated that a K ϩ channel with properties distinct from TASK channels contributes to the pH sensitivity of rat RTN neurons. Furthermore, the ventilatory response to CO 2 was completely retained in single or double TASK knock-out mice. These data rule out a strict requirement for TASK channels or raphe neurons in central respiratory chemosensation. Furthermore, they indicate that a non-TASK K ϩ current contributes to chemosensitivity of RTN neurons, which are profoundly pH-sensitive and capable of driving respiratory output in response to local pH changes in vivo.

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Section: Task Channel Contributions To Respirationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity

Mulkey¹,

Talley²,

Stornetta³

et al. 2007

J. Neurosci.

171

250

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“…Immunoprobing of a hippocampalexpression library with patients' antibodies resulted in the isolation of EFA6A, a protein that interacts with a member of the two-pore-domain potassium channel family and is involved in the regulation of the dendritic development of hippocampal neurons. Some members of this ion channel family (ie, TASK-1 and TASK-3) are known to play roles in controlling breathing and arousal [24,25].…”

Section: Novel Neuronal Antibodies Encephalitis Associated With Antibmentioning

confidence: 99%

“…Because EFA6A interacts with a member of the two-pore domain potassium channel, and some members of this potassium channel family seem to be important for control of breathing and arousal, it is tempting to speculate that the patients' antibodies disrupt the function of these channels [24,25].…”

Section: The Encephalitic Syndrome Associated With Ovarian Teratoma Amentioning

confidence: 99%

Clinical and Immunological Diversity of Limbic Encephalitis: A Model for Paraneoplastic Neurologic Disorders

Dalmau

Bataller

2006

Hematology/Oncology Clinics of North America

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The most important contribution to the understanding and management of paraneoplastic neurologic disorders (PND) is the discovery that many of these disorders are immune mediated. It is believed that cytotoxic T-cell responses and antibodies that target neuronal proteins usually expressed by the underlying tumor cause the neurologic symptoms [1]. The detection of these antibodies has provided diagnostic tests that allow recognition of the disorder as paraneoplastic and direct the search of the tumor to selected organs [2]. A better understanding of the function of the paraneoplastic neuronal (or onconeuronal) antigens along with modelling PND in animals results in improved treatment strategies. For the clinician who currently confronts these patients, however, the best chance to affect the neurologic outcome depends on: (1) the prompt diagnosis of the disorder, (2) the early discovery and treatment of the tumor, and (3) the use of immunotherapy. Likewise, any clinical features or tests suggesting that the patient's syndrome is not a PND are also important to prevent delays incurred by unnecessary oncologic evaluations.In 60% of patients who have PND the neurologic symptoms develop before the presence of cancer is known, so these patients are usually seen first by general practitioners or neurologists [6]. In an attempt to improve the recognition of these syndromes, the authors recently proposed a logical approach to the management of limbic encephalitis and postulated that many patients without well-characterized antibodies harbor novel immune responses [6,7]. This approach takes into consideration the type of syndrome, the neuroimaging and cerebrospinal fluid (CSF) findings, and whether the autoantigens are intracellular or are located in the cell membrane. Disorders associated with intracellular autoantigens usually associate with cytotoxic T-cell mechanisms and are less likely to improve than are disorders that associate with autoantigens in the cell membrane. This review summarizes the authors' findings of limbic encephalitis and postulate that a similar approach can be used for syndromes involving other areas of the nervous system.

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Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma

Vitaliani

Mason

Ances

et al. 2005

Annals of Neurology

535

347

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We report four young women who developed acute psychiatric symptoms, seizures, memory deficits, decreased level of consciousness, and central hypoventilation associated with ovarian teratoma (OT) and cerebrospinal fluid (CSF) inflammatory abnormalities. Three patients recovered with treatment of the tumor or immunosuppression and one died of the disorder. Five other OT patients with a similar syndrome and response to treatment have been reported. Our patients' serum or CSF showed immunolabeling of antigens that were expressed at the cytoplasmic membrane of hippocampal neurons and processes and readily accessed by antibodies in live neurons. Immunoprobing of a hippocampal-expression library resulted in the isolation of EFA6A, a protein that interacts with a member of the two-pore-domain potassium channel family and is involved in the regulation of the dendritic development of hippocampal neurons. EFA6A-purified antibodies reproduced the hippocampal immunolabeling of all patients' antibodies and colocalized with them at the plasma membrane. These findings indicate that in a young woman with acute psychiatric symptoms, seizures, and central hypoventilation, a paraneoplastic immune-mediated syndrome should be considered. Recognition of this disorder is important because despite the severity of the symptoms, patients usually recover. The location and function of the isolated antigen suggest that the disorder is directly mediated by antibodies.

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Cardiorespiratory neurons of the rat ventrolateral medulla contain TASK-1 and TASK-3 channel mRNA

Cited by 47 publications

References 47 publications

TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity

TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity

Clinical and Immunological Diversity of Limbic Encephalitis: A Model for Paraneoplastic Neurologic Disorders

Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma

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