Cardiorespiratory fitness and fat oxidation during exercise as protective factors for insulin resistance in sedentary women with overweight or obesity

Ramírez, Javiera Cancino; Sánchez, Johana Soto; Foncea, Hermann Zbinden; González, Manuel Moreno; Dinamarca, Bárbara Leyton; Rojas, Luis

doi:10.20960/nh.1279

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…In agreement, Cancino‐Ramírez et al (2018) showed that VO 2 max and MFO are protective factors for insulin resistance and, therefore, CMR in sedentary women with overweight or obesity. However, VO 2 max was more strongly associated with CMR, suggesting that VO 2 max is a better predictor compared to MFO.…”

Section: Discussionsupporting

confidence: 67%

“…range between 33% and 65% of VO 2 max) and the test ends when subject reaches a Respiratory Exchange Ratio (RER) = 1.0 (Achten et al, 2002). Moreover, MFO has shown to be related to some individual CMR factors such as insulin resistance, obesity, plasma triglycerides and body weight (Cancino‐Ramírez et al, 2018; Kelley, Goodpaster, Wing, & Simoneau, 2017; Robinson, Hattersley, Frost, Chambers, & Wallis, 2015; Rosenkilde, Nordby, Nielsen, Stallknecht, & Helge, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Maximal fat oxidation capacity is associated with cardiometabolic risk factors in healthy young adults

Montes-de-Oca-García

Pérez‐Bey

Corral-Pérez

et al. 2020

European Journal of Sport Science

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It is unknown whether resting fat oxidation (RFO), maximal fat oxidation (MFO) and FatMax (intensity at which MFO is reached) are related to cardiometabolic risk (CMR). Thus the aim of this study was to examine the association of RFO, MFO and FatMax with CMR. 81 healthy adults (n = 31 women; 22.72 ± 4.40 years) participated in this cross-sectional study. Glucose and triglycerides were analysed in plasma. Body composition, anthropometry, physical activity, blood pressure (BP) and heart rate measurements were taken. RFO and MFO were determined through indirect calorimetry. Maximal oxygen uptake (VO 2 max) test was performed until exhaustion after MFO test. The CMR cluster was created from individual CMR factors: waist circumference, body fat percentage, systolic BP, diastolic BP, blood glucose and plasma triglycerides. Groups of high and low MFO and VO 2 max were created. RFO was not associated with CMR (p < 0.05). FatMax, MFO and VO 2 max were associated with individual CMR factors as waist circumference (R 2 = 0.144; R 2 = 0.241; R 2 = 0.285; p = 0.001; respectively) and plasma triglycerides (R 2 = 0.111; p = 0.004 and R 2 = 0.130; p = 0.002 and R 2 = 0.093; p = 0.008; respectively) and clustered CMR factors (R 2 = 0.105; p = 0.008 and R 2 = 0.162; p = 0.001 and R 2 = 0.239; p = 0.001; respectively). VO 2 max was also associated with body fat percentage (R 2 = 0.105; p = 0.003) and diastolic BP (R 2 = 0.083; p = 0.01), even adjusting for sex or age (p < 0.05). Groups with high level of MFO or VO 2 max obtained lower CMR (p = 0.001), even adjusting for sex or age (p < 0.01). FatMax, MFO and, especially, VO 2 max are associated with CMR, regardless of age and sex. However, RFO is not associated with CMR.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Maximal fat oxidation capacity is associated with cardiometabolic risk factors in healthy young adults

Montes-de-Oca-García

Pérez‐Bey

Corral-Pérez

et al. 2020

European Journal of Sport Science

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“…In the incremental treadmill test, the MFO of the IR group was significantly smaller than that of the no-IR group, which is consistent with previous studies (Cancino Ramírez et al, 2018); under the same exercise intensity, both the AFO and RFO of the IR group were lower than those of the no-IR group, and the difference increased in significance with the exercise intensity. This phenomenon may be related to the mitochondrial dysfunction in the adipose tissue of the IR group.…”

Section: Discussionsupporting

confidence: 91%

Resting and exercise metabolic characteristics in obese children with insulin resistance

et al. 2022

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Purpose: This study aimed to explore the characteristics of resting energy expenditure (REE) and lipid metabolism during incremental load exercise in obese children and adolescents with insulin resistance (IR) to provide evidence for exercise intervention in obese children and adolescents with IR.Method: From July 2019 to August 2021, 195 obese children and adolescents aged 13–17 were recruited through a summer camp. The participants were divided into IR (n = 67) and no-IR (without insulin resistance, n = 128) groups and underwent morphology, blood indicators, body composition, and resting energy consumption gas metabolism tests. Thirty participants each were randomly selected from the IR and no-IR groups to carry out the incremental treadmill test.Results: Significant metabolic differences in resting and exercise duration were found between the IR and no-IR groups. In the resting state, the resting metabolic equivalents (4.33 ± 0.94 ml/min/kg vs. 3.91 ± 0.73 ml/min/kg, p = 0.001) and REE (2464.03 ± 462.29 kcal/d vs. 2143.88 ± 380.07 kcal/d, p < 0.001) in the IR group were significantly higher than in the no-IR group. During exercise, the absolute maximal fat oxidation (0.33 ± 0.07 g/min vs. 0.36 ± 0.09 g/min, p = 0.002) in the IR group was significantly lower than in the no-IR group; maximal fat oxidation intensity (130.9 ± 8.9 bpm vs. 139.9 ± 7.4 bpm, p = 0.040) was significantly lower in the IR group.Conclusion: Significant resting and exercise metabolic differences were found between obese IR and no-IR children and adolescents. Obese IR children and adolescents have higher REE and lower maximal fat oxidation intensity than obese no-IR children and adolescents.

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“…Different Metflex markers have been physiologically related to physical fitness and insulin sensitivity [ 2 , 4 , 6 , 8 , 10 , 13 , 14 , 24 ]. The present study aimed to determine their correlation particularly testing their association with body fatness while controlling for VO 2peak (mL∙kg −1 ∙min −1 ) in subjects with obesity.…”

Section: Discussionmentioning

confidence: 99%

Exercise Fat Oxidation Is Positively Associated with Body Fatness in Men with Obesity: Defying the Metabolic Flexibility Paradigm

Chávez-Guevara

Hernández-Torres

Trejo-Trejo

et al. 2021

IJERPH

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Obesity is thought to be associated with a reduced capacity to increase fat oxidation in response to physical exercise; however, scientific evidence supporting this paradigm remains scarce. This study aimed to determine the interrelationship of different submaximal exercise metabolic flexibility (Metflex) markers and define its association with body fatness on subjects with obesity. Twenty-one male subjects with obesity performed a graded-intensity exercise protocol (Test 1) during which cardiorespiratory fitness (CRF), maximal fat oxidation (MFO) and its corresponding exercise intensity (FATmax) were recorded. A week afterward, each subject performed a 60-min walk (treadmill) at FATmax (Test 2), and the resulting fat oxidation area under the curve (TFO) and maximum respiratory exchange ratio (RERpeak) were recorded. Blood lactate (LAb) levels was measured during both exercise protocols. Linear regression analysis was used to study the interrelationship of exercise Metflex markers. Pearson’s correlation was used to evaluate all possible linear relationships between Metflex and anthropometric measurement, controlling for CRF). The MFO explained 38% and 46% of RERpeak and TFO’s associated variance (p < 0.01) while TFO and RERpeak were inversely related (R2 = 0.54, p < 0.01). Body fatness positively correlated with MFO (r = 0.64, p < 0.01) and TFO (r = 0.63, p < 0.01) but inversely related with RERpeak (r = −0.67, p < 0.01). This study shows that MFO and RERpeak are valid indicators of TFO during steady-state exercise at FATmax. The fat oxidation capacity is directly associated with body fatness in males with obesity.

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Cardiorespiratory fitness and fat oxidation during exercise as protective factors for insulin resistance in sedentary women with overweight or obesity

Abstract: VO2(%) and MFO are independent protective factors for IR. No association was found between FATmax and IR.

Cited by 6 publications

References 34 publications

Maximal fat oxidation capacity is associated with cardiometabolic risk factors in healthy young adults

Maximal fat oxidation capacity is associated with cardiometabolic risk factors in healthy young adults

Resting and exercise metabolic characteristics in obese children with insulin resistance

Exercise Fat Oxidation Is Positively Associated with Body Fatness in Men with Obesity: Defying the Metabolic Flexibility Paradigm

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