Cardiorespiratory Effects of Experimental Lung Embolism*

Halmagyi, D; Colebatch, H. J. H.

doi:10.1172/jci104402

Cited by 61 publications

(29 citation statements)

References 33 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further, no increase in peak inspiratory pressure, reflecting dynamic lung compliance, was observed. In previous studies, the fall in lung compliance has been the most obvious change in lung mechanics, following pulmonary micro-embolism (Halmagyi & Colebatch, 1961;Nadel et al 1964), but this was only seen in this study at the higher dose of BaSO4 particles.…”

Section: Effects Of Microvascular Occlusioncontrasting

confidence: 55%

“…In this study, the bronchoconstriction, which followed the injection of collagen fibrils, was reduced by 60 % after section of the vagus nerves. On the other hand, other studies suggest that vagal connexions do not contribute to the genesis of airway constriction in response to BaSO4-induced pulmonary micro-embolism (Halmagyi & Colebatch, 1961;Nadel etal. 1964).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The role of prostaglandins in the bronchoconstriction induced by pulmonary micro‐embolism in the guinea‐pig.

Clay¹,

Hughes²

1980

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Respiratory resistance was measured by a forced oscillation technique in vagotomized guinea-pigs before and after pulmonary micro-embolism produced by i.v. injection of 0 5 ml./kg of 10 % w/v BaSO4. Changes in quasi-static inspiratory compliance and arterial platelet count were also measured.2. Micro-embolic challenge with BaSO4 increased respiratory resistance by 27 %; this was abolished by prior treatment with indomethacin; no change in the control resistance occurred after indomethacin.3. No change in respiratory compliance or arterial platelet numbers were observed following low dose BaSO4 micro-embolism. This suggests that pulmonary microembolism produced a decrease in medium or large airway calibre, which was mediated by a prostaglandin-like substance from lung tissue, and did not require the presence of the vagus nerves.

show abstract

Section: Effects Of Microvascular Occlusioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

The role of prostaglandins in the bronchoconstriction induced by pulmonary micro‐embolism in the guinea‐pig.

Clay¹,

Hughes²

1980

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…26,32 Smaller emboli (microemboli of Ͻ200 m) initiate pulmonary vasoconstriction, resulting in a considerable increase in pulmonary arterial pressure, even if less than 50% of the pulmonary arterial vasculature is blocked. 27,33 In the present study, the slight increase in pulmonary arterial pressure may have been a result of redistribution of blood flow after macroembolism, blocking less than 50% of the pulmonary arterial vasculature. Differences between the animal model and the clinical situation pertain to the limitations of the present study.…”

Section: Discussionmentioning

confidence: 54%

Cardiovascular Changes after Pulmonary Cement Embolism: An Experimental Study in Sheep

Krebs¹,

Aebli²,

Goss³

et al. 2007

American Journal of Neuroradiology

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:Most cement leaks during vertebroplasty are asymptomatic, but pulmonary cement embolism has been reported to cause cardiovascular disturbances and even death. Adding hydroxyapatite (HA) to polymethylmethacrylate (PMMA) cement to reduce the quantity of barium may aggravate cardiovascular deterioration in the event of cement embolism by activating coagulation. Thus, we investigated the cardiovascular changes after pulmonary cement embolism of PMMA with and without HA.

show abstract

“…The increase in pulmonary arterial pressure may have been caused by pulmonary vasoconstriction elicited by vasoactive mediators released from the bone marrow cavity or as a result of lung injury after embolization 38,39 . Alternatively, a reflex response to embolization may have elicited pulmonary vasoconstriction 40,41 . Methylmethacrylate has also been reported to cause pulmonary vasoconstriction 42,43 .…”

Section: Discussionmentioning

confidence: 99%

Influence of Bone Marrow Fat Embolism on Coagulation Activation in an Ovine Model of Vertebroplasty

Krebs

Ferguson

Hoerstrup

et al. 2008

The Journal of Bone & Joint Surgery

View full text Add to dashboard Cite

Influence of bone marrow fat embolism on coagulation activation in an ovine model of vertebroplasty Abstract BACKGROUND: Intraoperative cardiovascular deterioration as a result of pulmonary embolization of bone marrow fat is a potentially serious complication during vertebroplasty. The release of fatty material and thromboplastin from the bone marrow cavity during vertebroplasty may activate the coagulation cascade resulting in thrombogenesis, and pharmacological prophylaxis may therefore prevent cardiovascular complications. Thus, the effects of bone marrow fat embolism on coagulation activation during vertebroplasty were investigated with use of an animal model. METHODS: Polymethylmethacrylate was injected into three lumbar vertebrae of six sheep in order to force bone marrow fat into the circulation. Invasive blood pressures and heart rate were recorded continuously until sixty minutes after the last injection. Cardiac output, arterial and mixed venous blood gas parameters, and coagulation parameters were measured at selected time-points. Postmortem lung biopsy specimens were assessed for the presence of intravascular fat. RESULTS: Embolization of bone marrow fat resulted in a sudden and dramatic increase in mean pulmonary arterial pressure and a decrease in mean arterial blood pressure. There were no significant changes in any coagulation parameter from before the injection to after the injection. Intravascular fat and bone marrow cells were present in all lung lobes. CONCLUSIONS: Injection of polymethylmethacrylate into vertebral bodies caused embolization of bone marrow fat with subsequent transient cardiovascular deterioration, but no changes in coagulation parameters were observed. Thromboembolism did not contribute to the observed cardiovascular changes.

show abstract

Cardiorespiratory Effects of Experimental Lung Embolism*

Cited by 61 publications

References 33 publications

The role of prostaglandins in the bronchoconstriction induced by pulmonary micro‐embolism in the guinea‐pig.

The role of prostaglandins in the bronchoconstriction induced by pulmonary micro‐embolism in the guinea‐pig.

Cardiovascular Changes after Pulmonary Cement Embolism: An Experimental Study in Sheep

Influence of Bone Marrow Fat Embolism on Coagulation Activation in an Ovine Model of Vertebroplasty

Contact Info

Product

Resources

About