Abstract:Urethane is used in rats and dogs and is recognized to minimally suppress cardiorespiratory function, but little is known about its impact in mouse models. The overall purpose of this study was to comprehensively compare cardiorespiratory function in mice anesthetized with urethane, compared to conscious state. 16-week old C57BL6/J mice (n=30,15 males, 15 females), underwent measurements while conscious and urethane-anesthetized. Hemodynamic parameters including heart rate variability (HRV), blood pressure (BP… Show more
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