Cardiorespiratory and neuroendocrine changes induced by methadone in conscious and in isoflurane anaesthetised dogs

Garófalo, Natache Arouca; Neto, Francisco José Teixeira; Pereira, Carolina Dini Nuno; Pignaton, Wangles; Vicente, Flavia; Alvaides, Renata K.

doi:10.1016/j.tvjl.2012.03.019

Cited by 25 publications

(18 citation statements)

References 18 publications

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“…The likely explanation for this result is that a significant decrease in HR was also observed in dogs from these groups with the concomitant maintenance of SV values, which directly affects CI values. GAROFALO et al (2012) also observed decreases in HR and CI after methadone was administered, corroborating the findings of the present study. Regarding the parameters associated with diastolic function (E/A ratio, IVRT, E`-wave, and A`-wave), no significant differences were observed among the groups and time points (Table 3).…”

Section: ----------------Ab-------------------------------mam--------supporting

confidence: 92%

“…The animals from group M exhibited significantly higher BP values after sedation than dogs from groups AB, AM, and MAM (Table 1). As there was a significant decrease in CO values in dogs from group M (Table 2), it is likely that the maintenance of high BP values occurred due to an increase in pulmonary vascular resistance (PVR), given that this drug increases serum vasopressin concentrations (GAROFALO et al, 2012) and thus increases PVR.…”

Section: Resultsmentioning

confidence: 99%

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Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

et al. 2016

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The present study aimed to evaluate the effects of different sedation protocols on blood pressure and echocardiographic and electrocardiographic parameters in dogs. In total, 24 male mixed-breed dogs with a mean weight of 9.87±3.0kg were used.Animals were randomly divided into four groups (n=6), which were subjected to sedation using the following protocols: acepromazine (0.05mgkg -1 ) and butorphanol (0.3mgkg -1

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Section: ----------------Ab-------------------------------mam--------supporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

et al. 2016

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“…Respiratory depression may be induced by the use of opioids, depending on the dosage and administration route [13,32]. Importantly, this effect was not observed in this study, which may be related to the intramuscular administration employed, which alters absorption kinetics and leads to fewer side effects, representing an advantage over morphine.…”

Section: Discussionmentioning

confidence: 75%

“…This result may be related to the dosage employed in this study or the presence of injury/pain. In pain-free conscious dogs, Garofalo et al [32] reported the presence of dysphoria in all animals after 1 mg/kg of methadone was intravenously administered. In previous studies where tramadol was used for the control of postoperative pain after ovariohysterectomy, mandibulectomy, and maxillectomy, dysphoria was not observed [4,12,28].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effects of methadone and tramadol on postoperative analgesia and serum interleukin-6 in dogs undergoing orthopaedic surgery

et al. 2014

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BackgroundAcute postsurgical pain is of great interest due to potential risk of becoming chronic if not treated properly, worsening patient’s recovery and quality of life. Twenty-eight dogs with ruptured cruciate ligaments were divided into three groups that received intramuscular injections of 4 mg/kg of tramadol (TRA), 0.5 mg/kg of methadone (MET0.5), or 0.7 mg/kg of methadone (MET0.7). Physiological parameters (heart and respiratory rates and blood pressure) were evaluated at specified times: baseline (TBL), 1 (T1), 2 (T2), 4 (T4), 6 (T6), and 24 (T24) hours after premedication. Pain scores were described by visual analogue scale (VAS), modified Glasgow Composite, and Colorado University Acute Pain scales. Blood samples for measurement of interleukin (IL)-6 were collected at TBL, T1, T6, and T24. This was a prospective, randomised investigation to evaluate the efficacy of tramadol and methadone as premedications in dogs undergoing osteotomies.ResultsThere were no statistically significant differences between groups with respect to age, weight, gender, surgery time, and time to extubation. Heart rate, respiratory rate, and blood pressure values were maintained within acceptable ranges, and a reduction was observed at T2 in MET0.5 and MET0.7 compared with TBL. Increases in VAS scores were observed in TRA at T4 compared with TBL, T1, and T24 and between T1 and T6 (p < 0.001). In MET0.5, there was significant increase in VAS score at T4 compared with T1 (p < 0.001). TRA and MET0.5 showed significantly higher mean ± SD VAS scores (3.4 ± 2.5 and 2.5 ± 2.6, respectively) than MET0.7 (1.1 ± 1.5) at T4 (p < 0.001). TRA showed greater demand of rescue analgesia (four animals in T4 and two in T6) (p < 0.037). There were no statistically significant differences in sedation scores, Colorado Scale scores, or interleukin levels between groups and time points.ConclusionsMethadone given as premedication in doses of 0.7 mg/kg was better at controlling pain compared with lower doses and tramadol. However, dosage increases, administered as rescue analgesia, promoted adequate pain control even in tramadol group. Influence of these analgesics on IL-6 release could not be demonstrated, but significant levels were not found.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-014-0194-7) contains supplementary material, which is available to authorized users.

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“…Although these two models had different phenotypes, the results suggest that SHIP2 is a key regulator of glucose, and its inhibition would be useful regarding efforts to improve diet-induced obesity. Furthermore, transgenic mice expressing catalytically-inactive SHIP2 have displayed altered lipid metabolism and insulin secretion[82]. In addition transgenic mice over-expressing SHIP2 WT are obese and suffer from hepatic insulin resistance[83].…”

Section: Pi3k/ship2/pten Pathway and Insulin Resistancementioning

confidence: 99%

PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis

Awad

Gassama‐Diagne

2017

WJH

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Hepatitis C virus (HCV) infects hepatocytes, polarized cells in the liver. Chronic HCV infection often leads to steatosis, fibrosis, cirrhosis and hepatocellular carcinoma, and it has been identified as the leading cause of liver transplantation worldwide. The HCV replication cycle is dependent on lipid metabolism and particularly an accumulation of lipid droplets in host cells. Phosphoinositides (PIs) are minor phospholipids enriched in different membranes and their levels are tightly regulated by specific PI kinases and phosphatases. PIs are implicated in a vast array of cellular responses that are central to morphogenesis, such as cytoskeletal changes, cytokinesis and the recruitment of downstream effectors to govern mechanisms involved in polarization and lumen formation. Important reviews of the literature identified phosphatidylinositol (PtdIns) 4-kinases, and their lipid products PtdIns(4)P, as critical regulators of the HCV life cycle. SH2-containing inositol polyphosphate 5-phosphatase (SHIP2), phosphoinositide 3-kinase (PI3K) and their lipid products PtdIns(3,4)P2 and PtdIns(3,4,5)P3, respectively, play an important role in the cell membrane and are key to the establishment of apicobasal polarity and lumen formation. In this review, we will focus on these new functions of PI3K and SHIP2, and their deregulation by HCV, causing a disruption of apicobasal polarity, actin organization and extracellular matrix assembly. Finally we will highlight the involvement of this pathway in the event of insulin resistance and nonalcoholic fatty liver disease related to HCV infection.

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Cardiorespiratory and neuroendocrine changes induced by methadone in conscious and in isoflurane anaesthetised dogs

Cited by 25 publications

References 18 publications

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

Evaluation of the effects of methadone and tramadol on postoperative analgesia and serum interleukin-6 in dogs undergoing orthopaedic surgery

PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis

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