Objective: To assess the Nigerian primary and secondary school teachers' knowledge and attitude towards cardiopulmonary resuscitation (CPR). Methodology: A questionnaire-based cross-sectional study of Post NCE Sandwich students (primary and secondary school teachers) involving 322 -213(71%) females and 87(29%) males aged 22-60 years from 14 out of the 36 States of the Federal Republic of Nigeria. Originally, 325 copies of the questionnaire were distributed, giving a response rate of 92%. The data was analyzed using both descriptive and non-parametric statistics with statistical significance set at P < 0.05. Results: 64.29% gave wrong answers to questions on CPR knowledge with rejection of the null hypothesis on their CPR knowledge, meaning that the participants significantly had poor knowledge of CPR (P <.05) while 79.9% showed positive attitude towards CPR with the null hypothesis on their attitude towards CPR (meaning that the teachers significantly wanted CPR teaching and training in Nigerian schools, P< .05).