Cardiopulmonary exercise testing with supramaximal verification produces a safe and valid assessment of V̇<scp>o</scp><sub>2max</sub> in people with cystic fibrosis: a retrospective analysis

Causer, Adam J.; Shute, Janis K.; Cummings, Michael H.; Shepherd, Anthony I.; Bright, Victoria; Connett, Gary; Allenby, Mark I.; Carroll, Mary; Daniels, T.; Saynor, Zoe L.

doi:10.1152/japplphysiol.00454.2018

Cited by 29 publications

(30 citation statements)

References 35 publications

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“…The main outcome of aerobic capacity is the peak oxygen uptake (VO 2 peak), defined as the maximum amount of oxygen that can be absorbed during exercise . Cardiopulmonary exercise testing (CPET) is considered the gold standard for the assessment of physical fitness, evaluating the interaction of cardiovascular, respiratory, and metabolic systems . However, the performance of CPET is still not available in many CF centers due to the need of high cost equipment (treadmill or cycle ergometer and a gas analysis system) and highly trained staff.…”

Section: Introductionmentioning

confidence: 99%

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Vendrusculo

Heinzmann‐Filho

Campos

et al. 2019

Pediatric Pulmonology

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Background: Several tests may be used to assess exercise intolerance in cystic fibrosis (CF), including the gold standard cardiopulmonary exercise test (CPET) and the Modified Shuttle Test (MST).Objective: To evaluate the use of the MST as a predictor of peak oxygen uptake (VO 2 peak) and to compare VO 2 peak and maximal heart rate (HRmax) obtained in both tests.Methods: Cross-sectional study including individuals with CF aged between 6 and 20 years old. Participants who were unable to perform the tests and/or presented signs of pulmonary exacerbation were excluded. Demographic, anthropometric, clinical and spirometric values were collected. CPET and the MST were performed in two consecutive outpatient visits. HRmax, peripheral oxygen saturation, dyspnea, and VO 2 peak measured and estimated were compared.Results: Twenty-four patients, mean age 15.7 ± 4.2 years and FEV 1 (% predicted) 76.4 ± 23.8, were included. Mean values of HRmax (bpm) and HRmax in percent of predicted (HRmax%) were lower (P = 0.01) in the MST (171.6 ± 14.5 and 87.1 ± 7.5) compared to CPET (180.9 ± 10.0 and 91.9 ± 5.4). However, there was no significant differences between tests in the variation (delta) for HRmax and HRmax% (P = 0.17). A strong correlation (r = 0.79; P < 0.0001) was found between distance achieved (MST) and VO 2 peak (CPET). The regression model to estimate VO 2 peak resulted in the following equation: VO 2 (mL · kg −1 · min −1 ) = 20.301 + 0.019 × MST distance (meters). There was no difference (P = 0.50) between VO 2 peak measured (CPET) and estimated by the equation. Conclusion:The MST may be an alternative method to evaluate exercise capacity and to predict VO 2 peak in children and adolescents with CF.

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Section: Introductionmentioning

confidence: 99%

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Vendrusculo

Heinzmann‐Filho

Campos

et al. 2019

Pediatric Pulmonology

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“…After an incremental CPET, participants will be provided with a ten-minute break. They will then be asked to complete a supramaximal exercise test (Causer et al, 2018, Saynor et al, 2013 whereby participants will exercise at 110% of their power output (as determined by CPET test previously). This test has been conducted amongst PWCF previously and has been deemed safe and ensures validity of the results which are obtained in a CPET test.…”

Section: Methodsmentioning

confidence: 99%

Steps Ahead: optimising physical activity and health in people with cystic fibrosis: Study Protocol for a pilot randomised trial

et al. 2020

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Background: Physical activity (PA) and exercise are widely documented as key components in the management of cystic fibrosis (CF). In recent years there have been significant improvements in telehealth, in particular; fitness tracking, smartphone use and remote monitoring, all of which may have potential to impact on positive health outcomes in people with CF. The objective of this pilot randomised trial is to explore the potential efficacy of a fitness tracker, which is remotely monitored, combined with personalised text message feedback and goal setting, on lung function, aerobic capacity and PA in adults with CF. Secondary endpoints include quality of life, body composition and wellbeing. Methods: This is a pilot randomised trial which will be conducted at the University Hospital Limerick, Ireland. Participants will be randomised to the intervention or active comparator after their baseline assessment. The 12-week intervention will consist of a fitness tracker (Fitbit Charge 2) which is linked to an online monitoring system (Fitabase) for data collection purposes that enables the physiotherapist to remotely monitor participant data. The CF physiotherapist will set short- and long-term goals with participants and will send one-way text message feedback on Fitbit data and weekly progress. This message will consist of positive reinforcement and re-assess participant goals. The active comparator group will receive a fitness tracker which is also linked to Fitabase; however, no feedback will be provided to participants in this group. Both groups will be re-assessed at 12 weeks. After this point, both groups will continue with the Fitbit alone for a further 12 weeks. Both groups will be re-assessed at 24 weeks. Discussion: This is a novel concept which utilises modern technology, remote monitoring and personalised feedback to investigate the effect on health outcomes in people with CF. Trial registration: ClinicalTrials.gov NCT03672058 (14/09/2018)

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“…After an incremental CPET, participants will be provided with a ten-minute break. They will then be asked to complete a supramaximal exercise test (Causer et al, 2018;Saynor et al, 2013) whereby participants will exercise at 110% of their power output (as determined by CPET test previously). This test has been conducted amongst adults with CF previously and has been deemed safe and ensures validity of the results which are obtained in a CPET test.…”

Section: Cardiopulmonary Exercise Testingmentioning

confidence: 99%

Steps Ahead: optimising physical activity in adults with cystic fibrosis: Study Protocol for a pilot randomised trial using wearable technology

et al. 2020

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Background: Physical activity (PA) and exercise are widely documented as key components in the management of cystic fibrosis (CF). In recent years there have been significant improvements in telehealth, in particular; wearable technology, smartphone use and remote monitoring, all of which may have potential to impact on PA in adults with CF. The objective of this pilot randomised trial is to explore the effect of wearable technology, which is remotely monitored, combined with personalised text message feedback and goal setting, on PA in adults with CF. Secondary endpoints include lung function, aerobic capacity, quality of life, body composition, wellbeing and sleep. Methods: This is a pilot randomised trial which will be conducted at the University Hospital Limerick, Ireland. Participants will be randomised to the intervention or active comparator after their baseline assessment. The 12-week intervention will consist of wearable technology (Fitbit Charge 2) which is linked to an online monitoring system (Fitabase) that enables the physiotherapist to remotely monitor participant data. The CF physiotherapist will set individualised PA goals with each participant at baseline and will send text message feedback each week. The text messages will be personalised, one-way texts with positive reinforcement on step count attained by the participant. The active comparator group will receive this wearable technology which is also linked to Fitabase; however, no feedback will be provided to participants in this group. Both groups will be re-assessed at 12 weeks. After this point, both groups will continue with the Fitbit alone for a further 12 weeks. Both groups will be re-assessed at 24 weeks. A semi structured interview will assess satisfaction and acceptability of the intervention. Discussion: This is a novel concept which utilises modern technology, remote monitoring and personalised feedback to investigate the effect on PA in adults with CF. Trial registration: ClinicalTrials.gov NCT03672058 (14/09/2018)

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Cardiopulmonary exercise testing with supramaximal verification produces a safe and valid assessment of V̇o_2max in people with cystic fibrosis: a retrospective analysis

Abstract: Given the clinical importance of aerobic fitness in people with CF, incorporating S is recommended to provide a safe and valid measure of V̇O in children, adolescents and adults who span the spectrum of CF disease severity.

Cited by 29 publications

References 35 publications

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Steps Ahead: optimising physical activity and health in people with cystic fibrosis: Study Protocol for a pilot randomised trial

Steps Ahead: optimising physical activity in adults with cystic fibrosis: Study Protocol for a pilot randomised trial using wearable technology

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Cardiopulmonary exercise testing with supramaximal verification produces a safe and valid assessment of V̇o2max in people with cystic fibrosis: a retrospective analysis

Abstract: Given the clinical importance of aerobic fitness in people with CF, incorporating S is recommended to provide a safe and valid measure of V̇O in children, adolescents and adults who span the spectrum of CF disease severity.

Cited by 29 publications

References 35 publications

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Prediction of peak oxygen uptake using the modified shuttle test in children and adolescents with cystic fibrosis

Steps Ahead: optimising physical activity and health in people with cystic fibrosis: Study Protocol for a pilot randomised trial

Steps Ahead: optimising physical activity in adults with cystic fibrosis: Study Protocol for a pilot randomised trial using wearable technology

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Cardiopulmonary exercise testing with supramaximal verification produces a safe and valid assessment of V̇o_2max in people with cystic fibrosis: a retrospective analysis