Cardiopulmonary exercise testing in obstructive sleep apnea syndrome

Lin, Ching-Chi; Hsieh, Wen-Shyang; Chou, Chon-Shin; Liaw, Shwu-Fang

doi:10.1016/j.resp.2005.01.008

Cited by 81 publications

(88 citation statements)

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“…Some studies have revealed no reduction in aerobic capacity on the cycle ergometer test, (12,13) whereas others have reported a significant reduction. (14,15) One study showed a significant increase in VO 2 max after the use of noninvasive support ventilation.…”

Section: Discussionmentioning

confidence: 99%

“…(11) All of the compartments involved are determinants of exercise capacity. Some authors have found reduced exercise capacity in patients with OSAS, (12,13) although others have demonstrated no such impairment. (14,15) It is also known that increases in the levels of C-reactive protein (CRP), platelets, fibrinogen, and interleukin-6 are associated with nocturnal hypoxemia in patients with OSAS, (16) together with altered autonomic tone, (11) altered daytime catecholaminergic activity, (17) and increased diastolic blood pressure (DBP) during maximal exercise.…”

Section: Introductionmentioning

confidence: 99%

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Efeitos sistêmicos da hipoxemia noturna em pacientes com doença pulmonar obstrutiva crônica sem síndrome da apnéia obstrutiva do sono

et al. 2008

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Objective: To study the effects of nocturnal hypoxemia in patients with chronic obstructive pulmonary disease without obstructive sleep apnea syndrome. Methods: We studied 21 patients-10 desaturators and 11 nondesaturators-submitted to arterial blood gas analysis, polysomnography, spirometry, cardiopulmonary exercise testing (cycle ergometer), and hand-grip dynamometry, as well as measurements of maximal inspiratory pressure, maximal expiratory pressure, and C-reactive protein (CRP) levels. Patients with arterial oxygen tension > 60 mmHg were included; those with an apnea-hypopnea index > 5 events/hour of sleep were excluded. Maximal oxygen uptake, maximal power, systolic blood pressure, diastolic blood pressure (DBP), and maximal heart rate were measured during exercise in order to detect hemodynamic alterations. Patients presenting CRP levels above 3 mg/L were considered CRP-positive. Results: Minimum peripheral oxygen saturation during sleep was significantly higher among nondesaturators (p = 0.03). More desaturators presented CRP > 3 mg/L (p < 0.05). No differences were observed in terms of any variables. However, mean oxygen saturation during sleep correlated with DBP and maximal inspiratory pressure (p < 0.001 and p = 0.001, respectively). Conclusions: Although nocturnal hypoxemia does not reduce exercise capacity or hand-grip strength in patients with mild/moderate COPD, its effect on maximal exercise DBP seems to depend on the degree of hypoxemia. In addition, there is a positive relationship between maximal inspiratory pressure and mean oxygen saturation during sleep, as well as evidence of pronounced inflammatory activation in patients with nocturnal hypoxemia.Keywords: Pulmonary disease, chronic obstructive; Exercise test; Anoxia; Respiratory function tests. ResumoObjetivo: Estudar os efeitos da hipoxemia noturna em pacientes com doença pulmonar obstrutiva crônica sem síndrome da apnéia obstrutiva do sono. Métodos: Estudamos 21 pacientes-10 dessaturadores e 11 não-dessaturadores-submetidos a gasometria arterial, polissonografia, espirometria, teste de exercício cardiopulmonar (cicloergômetro), dinamometria manual e medidas de pressão inspiratória máxima, pressão expiratória máxima e proteína C reativa (PCR). Incluíram-se os pacientes com pressão parcial arterial de oxigênio > 60 mmHg; excluíram-se os com índice de apnéia-hipopnéia > 5 eventos/hora de sono. Foram medidos consumo máximo de oxigênio, potência máxima, pressão arterial sistólica, pressão arterial diastólica (PAD) e frequência cardíaca máxima durante exercício, visando detectar alterações hemodinâmicas. A PCR foi considerada positiva quando acima de 3 mg/L. Resultados: A saturação periférica de oxigênio mínima durante o sono foi significativamente maior nos não-dessaturadores (p = 0,03). Mais dessaturadores apresentaram PCR > 3 mg/L (p < 0,05). Não houve diferença quanto a capacidade de exercício e demais variáveis. No entanto, PAD (p < 0,001) e pressão inspiratória máxima (p = 0,001) correlacionaram-se com saturação periférica de o...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efeitos sistêmicos da hipoxemia noturna em pacientes com doença pulmonar obstrutiva crônica sem síndrome da apnéia obstrutiva do sono

et al. 2008

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“…While both tests were in progress, the players were given continual verbal encouragement. [35][36] The subjective perception of effort was estimated in each stage by means of Borg's graduated linear scale of 15 points (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). [37][38][39] In the present study, the test was considered to have reached the maximum when the soccer players attained 2 of the following validation criteria: 1) maximum respiration exchange ratio (RER) ≥ 1.10; 2) Borg´s scale of subjective perception of tiredness ≥ 18 and 3) maximum heart rate ≥ 95% of the maximum chronotropic response predicted for the age.…”

Section: Logistics Of the Testsmentioning

confidence: 99%

“…7 Maximum oxygen consumption is considered to be one of the most important parameters for aerobic function and has become extremely useful for evaluating cardiorespiratory performance in health and illness. [8][9][10][11][12][13] Another important point to be considered as a prerequisite for studying the validity of any assessment procedure is the reproducibility of its measurements. 14 In ergometry, various effort test protocols using treadmills and/or cycle ergometers, with different models for load increases, stage duration, and styles (ramped, stepped, or intermittent) have been used for testing VO 2max and other metabolic variables.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of Maximum Aerobic Power (Vo2max) Among Soccer Players Using a Modified Heck Protocol

Silva

Fonseca

Castro

et al. 2007

Clinics

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JM; Hernandez AJ. Reproducibility of maximum aerobic power (VO 2max ) among soccer players using a modified heck protocol. Clinics. 2007;62(4):391-6. OBJECTIVE:To determine the degree of reproducibility of maximum oxygen consumption (VO 2max ) among soccer players, using a modified Heck protocol. METHODS: 2 evaluations with an interval of 15 days between them were performed on 11 male soccer players. All the players were at a high performance level; they were training for an average of 10 hours per week, totaling 5 times a week. When they were evaluated, they were in the middle of the competitive season, playing 1 match per week. The soccer players were evaluated on an ergometric treadmill with velocity increments of 1.2 km . h -1 every 2 minutes and a fixed inclination of 3% during the test. VO 2max was measured directly using a breath-by-breath metabolic gas analyzer. RESULTS:The maximum running speed and VO 2max attained in the 2 tests were, respectively: (15.6 ± 1.1 vs. 15.7 ± 1.2 km ; [P = .88]). There was high and significant correlation of VO 2max between the 2 tests with a 15-day interval between them [r = 0.97; P < .001]. CONCLUSION: The modified Heck protocol was reproducible, and the 15-day interval between the ergospirometric testing was insufficient to significantly modify the soccer players' VO 2max values.

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“…A person's sex also has an influence on exercise capacity, which could be at least 20%-40% lower in women than in men (15). These variables have not always been considered, however, when interpreting the results of studies that have evaluated exercise capacity in patients with OSA (2)(3)(4)(5)(6)(7)(8)(9)(10)12). Moreover, these reports have included only a small number of women; therefore, their results might not extend to this population.…”

Section: Introductionmentioning

confidence: 99%

Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

et al. 2017

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INTRODUCTION:To study exercise capacity and heart rate (HR) recovery after peak exercise in morbidly obese female patients with obstructive sleep apnoea (OSA). METHODS:Twenty-four morbidly obese female patients (36.17 ± 9.20 years and 45.20 ± 5.41 kg.m diagnosed with OSA underwent cardiopulmonary exercise testing (CPET) for assessment of peak oxygen uptake (V'O2) and heart rate (HR) recovery at 30, 60 a index [AHI] <15 h-1) and moderate-to-severe (AHI RESULTS: For the entire study population, peak V'O2 was 15.58 ± 2.44 ml.min were found between moderate-to-severe and mild OSA (16.11 ± 2.37 vs. 15.19 ± 2.50 ml.min respectively). HR recovery registered at any time after the peak workload also did not differ between both groups. Nonetheless, the percentage of HR decrease at 90 seconds in the patients with moderate-to-severe OSA (p=.073), and it was negatively correlated with the oxygen desaturation index (r =-0.679, p=.044). CONCLUSION:Exercise capacity is not different bet Nevertheless, patients with moderatethose with milder OSA. Finally, the oxygen desaturation index is related to this slower chron Keywords: Obstructive sleep apnoea, Exercise test, Female, Heart rate, Obesity. Received March 20, 2017; Accepted May 11, 2017 Copyright: © 2017 Authors. This is an open License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and sourc credited. Editor: Javier Jareño Cite as: Carpio C., Santiago A., Gómez-Mendieta M., Caballero P., Martín capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrom IBJ Plus 2017 1(1):e0004. Funding: The author(s) declared that no grants were involved in supporting this work. To study exercise capacity and heart rate (HR) recovery after peak exercise in morbidly obese female patients with obstructive sleep apnoea (OSA).four morbidly obese female patients (36.17 ± 9.20 years and 45.20 ± 5.41 kg.m diagnosed with OSA underwent cardiopulmonary exercise testing (CPET) for assessment of peak oxygen uptake (V'O2) and heart rate (HR) recovery at 30, 60 and 90 seconds. Comparisons were made between mild (apnoea severe (AHI ≥15 h-1) OSA.For the entire study population, peak V'O2 was 15.58 ± 2.44 ml.min-1.kg-1. No differences in peak V'O2 severe and mild OSA (16.11 ± 2.37 vs. 15.19 ± 2.50 ml.min respectively). HR recovery registered at any time after the peak workload also did not differ between both groups. Nonetheless, the percentage of HR decrease at 90 seconds of recovery time was almost statistically significantly lower severe OSA (p=.073), and it was negatively correlated with the oxygen desaturation Exercise capacity is not different between patients with mild and moderate -to-severe OSA tend to have a slower HR recovery response to exercise than those with milder OSA. Finally, the oxygen desaturation index is related to this slower chronotropic response.Obstructive sleep apnoea, Exercise test, Female, Heart rate, Obesity.May 11, 2017; Published May 23, 2017...

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Cardiopulmonary exercise testing in obstructive sleep apnea syndrome

Cited by 81 publications

References 34 publications

Efeitos sistêmicos da hipoxemia noturna em pacientes com doença pulmonar obstrutiva crônica sem síndrome da apnéia obstrutiva do sono

Efeitos sistêmicos da hipoxemia noturna em pacientes com doença pulmonar obstrutiva crônica sem síndrome da apnéia obstrutiva do sono

Reproducibility of Maximum Aerobic Power (Vo2max) Among Soccer Players Using a Modified Heck Protocol

Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

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