Cardiopulmonary effects of overnight indoor air filtration in healthy non-smoking adults: A double-blind randomized crossover study

Cui, Xiaojie; Li, Feng; Xiang, Jianbang; Lin, Fang; Chung, M. S.; Day, Drew B; Mo, Jinhan; Weschler, Charles J.; Gong, Jicheng; He, Linchen; Zhu, Dong; Lu, Chengjian; Han, Hailong; Zhang, Yinping; Zhang, Junfeng Jim

doi:10.1016/j.envint.2018.02.010

Cited by 87 publications

(54 citation statements)

References 46 publications

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“…Previous studies have investigated different kinds of air purifiers and their health effects. The mechanic filters, such as high-efficiency air particulate (HEPA) filtration purifiers, could lower indoor pollution and have cardiorespiratory benefits in human subjects (Huichu Li et al, 2017;Luo et al, 2018;Liu et al, 2018;Butz et al, 2011;Kajbafzadeh et al, 2015) while other studies demonstrated that HEPA air purifiers could not significantly improve cardiorespiratory function in adults (Cui et al, 2018;Day et al, 2017a). Also, some researchers paid attention to other types of purifiers, such as electrostatic precipitator purifiers (ESP) (Day et al, 2017a;Skulberg et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Different cardiorespiratory effects of indoor air pollution intervention with ionization air purifier: Findings from a randomized, double-blind crossover study among school children in Beijing

Dong

Liu

Chu

et al. 2019

Environmental Pollution

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Indoor air pollution is associated with numerous adverse health outcomes. Air purifiers are widely used to reduce indoor air pollutants. Ionization air purifiers are becoming increasingly popular for their low power consumption and noise, yet its health effects remain unclear. This randomized, double-blind crossover study is conducted to explore the cardiorespiratory effects of ionization air purification among 44 children in Beijing. Real or sham purification was performed in classrooms for 5 weekdays. Size-fractionated particulate matter (PM), black carbon (BC), ozone (O3), and negative air ions (NAI) were monitored, and cardiorespiratory functions were measured. Mixed-effect models were used to establish associations between exposures and health parameters. Real purification significantly decreased PM and BC, e.g. PM0.5, PM2.5, PM10 and BC were dereased by 48%, 44%, 34% and 50% respectively. O3 levels were unchanged, while NAI was increased from 12 to 12,997 cm-3. Real purification was associated with a 4.4% increase in forced exhaled volume in 1 second (FEV1) and a 14.7% decrease in exhaled nitrogen oxide (FeNO). However, heart rate variability (HRV) was altered negatively. Interaction effects of NAI and PM were observed only on HRV, and alterations in HRV were greater with high NAI. Ionization air purifier could bring substantial respiratory benefits, however, the potential negative effects on HRV need further investigation.

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Section: Introductionmentioning

confidence: 99%

Different cardiorespiratory effects of indoor air pollution intervention with ionization air purifier: Findings from a randomized, double-blind crossover study among school children in Beijing

Dong

Liu

Chu

et al. 2019

Environmental Pollution

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“…Previous studies have shown that air purifiers with high‐efficiency particulate air (HEPA) filtration characteristics significantly reduce the concentration of indoor particles in homes and schools . However, studies reporting on the impact of HEPA filtration on health outcomes have had varied results . While there were statistically significant benefits of particle filtration on health outcomes for those with asthma and allergic rhinitis, these improvements were defined as “modest.” It should be noted, however, that a recent study by Jia‐Ying et al reported improvements in allergic rhinitis symptoms by using HEPA filtration .…”

Section: Introductionmentioning

confidence: 99%

HEPA filtration improves asthma control in children exposed to traffic‐related airborne particles

et al. 2019

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Traffic‐related airborne particles are associated with asthma morbidity. The aim of this study was to assess the impact of a high‐efficiency particulate air (HEPA) filtration on the concentrations of traffic particles and the resultant effect on children with asthma. Forty‐three children with asthma were enrolled in this double‐blind, placebo‐controlled crossover design. A HEPA air cleaner or a placebo “dummy” was placed in participants’ homes for four weeks, interrupted by a one‐month washout period, before crossing over to the other treatment arm for four weeks. Air sampling and health outcomes, including asthma control (ACQ) and quality of life (AQLQ) measures, were completed prior to and at the end of each treatment arm. Indoor concentrations of traffic particles were significantly reduced with the HEPA treatment but not with the “dummy” treatment. In participants with poorly controlled asthma and lower quality of life at baseline, ACQ and AQLQ scores were significantly improved (1.3 to 0.9, P = .003 and 4.9 to 5.5, P = .02, respectively) following the HEPA treatment. In this study, HEPA filtration is associated with improved clinical outcomes and quality of life measures in children with uncontrolled asthma.

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“…Such as, the increase of PM2.5 concentration is closely correlated to the hospitalization rate and mortality associated with respiratory diseases [6][7][8][9]. Long-term exposure to PM2.5 can lead to an increase in emphysema [10] and small airway resistance [11]. The meta-analysis of global association of air pollution and heart failure indicated that air pollution especially the high concentration of PM2.5 has a close temporal association with heart failure hospitalization and heart failure mortality [12].…”

Section: Background and Rationalementioning

confidence: 99%

Effect of probiotics on nasal and intestinal microbiota in people with high exposure to particulate matter ≤ 2.5 μm (PM2.5): a randomized, double-blind, placebo-controlled clinical study

Pei

Wang

et al. 2020

Trials

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Background Extended exposure to high concentrations of PM2.5 changes the human microbiota profile, which in turn may increase morbidity and mortality due to respiratory system damage. A balanced microecosystem is crucial to human health, and certain health-related problems may be addressed by effective microecosystem regulation. Recent studies have confirmed that probiotics may reduce the incidence of respiratory diseases. However, few studies have investigated probiotic treatment outcomes in subjects exposed to high concentrations of PM2.5. Methods This study is designed as a prospective, randomized, participants- and assessor-blinded, placebo-controlled trial. One hundred and twenty eligible volunteers recruited from October 2019 to July 2020 in downtown Chengdu, China, will be treated with either probiotics or placebo over 4 consecutive weeks. The primary outcome will be 16SrRNA sequencing assay data from nasal and intestinal secretions. Secondary outcomes will be pulmonary function, score on a gastrointestinal symptom rating scale, COOP/WONCA charts, and the Short-Form Health Survey 36 for quality of life. Results will be analyzed to assess differences in clinical efficacy between groups. Six-month follow-up examinations will evaluate the long-term value of probiotics on cardiovascular and respiratory disease end-point events. Discussion We will explore the characteristics of nasal and intestinal microbiota in a population with high exposure to PM2.5. Probiotics and placebo interventions will be tested for efficacy in microbial balance regulation, effects on lung and physical functions, and quality of life improvement. This study is expected to provide reliable evidence to support the widespread promotion of probiotics in clinical practice for the protection of individuals with high exposure to PM2.5. Trial registration Chinese Clinical Trial Registry ChiCTR1900025469. Registered on 27 August 2019.

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Cardiopulmonary effects of overnight indoor air filtration in healthy non-smoking adults: A double-blind randomized crossover study

Cited by 87 publications

References 46 publications

Different cardiorespiratory effects of indoor air pollution intervention with ionization air purifier: Findings from a randomized, double-blind crossover study among school children in Beijing

Different cardiorespiratory effects of indoor air pollution intervention with ionization air purifier: Findings from a randomized, double-blind crossover study among school children in Beijing

HEPA filtration improves asthma control in children exposed to traffic‐related airborne particles

Effect of probiotics on nasal and intestinal microbiota in people with high exposure to particulate matter ≤ 2.5 μm (PM2.5): a randomized, double-blind, placebo-controlled clinical study

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