Cardiopulmonary Effects of Intralipid Infusion in Critically III Patients

Isenstein, Douglas A.

doi:10.1097/00003246-198907000-00028

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“…Increased serum and myocardial triglyceride have been shown to suppress ischemic myocardial performance both in animal models 42,43 and human subjects. 44,45 Under conditions of hypoxia and ischemia, myocardial substrate preference shifts to Beta oxidation of FFA, which consumes approximately 11% larger phosphate-to-oxygen ratios compared to glucose. 46 In addition, the increased oxygen consumption of FFA oxidation resulted in a relatively low efficiency in ATP generation, and high FFA loads may activate cycling of FFA in and out of the triglyceride pool, which is futile and energy-consuming.…”

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<p>Supplement of Lipid Emulsion to Epinephrine Improves Resuscitation Outcomes of Asphyxia-Induced Cardiac Arrest in Aged Rats</p>

Huang

Ren

et al. 2020

CIA

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The goal of the study was to investigate the efficacy of lipid supplement to epinephrine-based therapy in resuscitation of asphyxia-induced cardiac arrest in aged rats. Methods: The study included two parts: in experiment A, rats underwent asphyxial cardiac arrest and cardiopulmonary resuscitation, randomized to receive epinephrine and normal saline (control group, n=22), epinephrine and intralipid 20% (long-chain triglycerides (LCT) group, n=22) or epinephrine and lipovenoes 20% (LCT/medium-chain triglcerides (MCT) group, n=22). Return of spontaneous circulation, recurrence of asystole after resuscitation, hemodynamic metrics, arterial blood gas values, neurological assessment score and indexes of pulmonary transudation were recorded. In experiment B, rats using the same model and resuscitation protocol were randomly divided into 21 groups: Control 0 , Control 20 ,

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