Cardiopulmonary bypass in a rat model may shorten the lifespan of stored red blood cells by activating caspase-3
Lu Han,
Lianlian Li,
Hangya Linghu
et al.
Abstract:Background
Red blood cell transfusion is required for many types of surgery against cardiovascular disease, and the function of transfused cells appears to decline over time. The present study examined whether transfusion also reduces red blood cell lifespan in a rat model.
Material and methods
Bypass in rats were established by connecting a roll pump to the femoral artery and vein. Then FITC-labeled stored red blood cells from rats were transfused in the animals, and the cells in circulation were counted af… Show more
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