Cardiopulmonary arrest and pneumoencephaly developing after epidural oxygen-ozone mixture therapy

Beyaz, Serbülent Gökhan; Altaş, Cafer; Sayhan, Havva

doi:10.4103/aer.aer_142_17

Cited by 10 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study used a 13‐mm injector tip. A case of cardiopulmonary arrest has been reported after O 3 /O 2 injection in the epidural cavity . No major complication has been reported with lumbar paravertebral ozone injection.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain

et al. 2019

View full text Add to dashboard Cite

Aim Paravertebral ozone injection is a new treatment method described in the literature for low back pain. The aim of this study was to compare the pre‐ and post‐treatment pain scores of patients undergoing paravertebral ozone/oxygen (O3/O2) injections for low back pain. Methods From September 2018 to December 2018, 122 patients who underwent paravertebral ozone injections due to low back pain were examined retrospectively; 62 patients who met the study criteria were included. The patients were injected with 15 µg/mL (50 mL) O3/O2 gas in the paravertebral space. The subjects were treated every 7 days for 6 total session. The VAS and Oswestry Disability Index (ODI) scores were assessed before treatment and after treatment (first and third months). The patients’ body mass indexes (BMIs) were measured before the injections. Results There were 12 male patients and 50 female patients. The mean age was 51.9 (range 25 to 71) years. The mean duration of pain was 9.1 (3 to 24) months. Significant improvements were observed in the statistical comparison of VAS and ODI scores between the pre‐injection and first month controls (P < 0.000). There was no significant difference in the statistical comparison of VAS and ODI scores between the first and third months (P < 0.05). There was no statistically significant difference between BMI and pain scores (P > 0.213). Conclusion Paravertebral O3/O2 gas is a reliable and effective treatment for the treatment of lumbar disc herniation, radicular pain, and mechanical back pain due to low back pain.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In addition, many studies have also reported on available scientific evidence concerning the beneficial properties of ozone therapy of pain, resulting in ozone therapy being widely used in pain management 19,20. However some complications of oxygen-ozone therapy still exist, such as headache pain, pneumocephalus, and cardiopulmonary arrest 21,22…”

Section: Introductionmentioning

confidence: 99%

“… 19 , 20 However some complications of oxygen-ozone therapy still exist, such as headache pain, pneumocephalus, and cardiopulmonary arrest. 21 , 22 …”

Section: Introductionmentioning

confidence: 99%

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Hu¹,

Zheng²,

Liu³

et al. 2018

JPR

View full text Add to dashboard Cite

IntroductionWe investigated the effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia (PHN).MethodsNinety-eight patients with PHN were enrolled in this study and randomly divided into a pharmacological therapy group and ozone autohemotherapy group (49 patients in each group). The PHN patients in the pharmacological therapy group were administered pharmacological therapy for 2 weeks, whereas PHN patients in the ozone autohemotherapy group were given ozone autohemotherapy (200 mL blood from patients, the concentration of medical ozone was set as 30 μg/mL using an ozone medical apparatus, 40 mL medical ozone was incubated in 200 mL autologous blood for 3–5 minutes) combined with pharmacological therapy for 2 weeks. The Visual Analog Scale (VAS), the 50% VAS reduction in the initial value, McGill Pain Questionnaire (MPQ), the Patients’ Global Impression of Change (PGIC) scale, and the World Health Organization Quality of Life (WHOQOL-BREF) instrument were used to evaluate the outcomes of all PHN patients before therapy and at 1 week, 1 month, and 3 months after therapy.ResultsForty-five patients in the pharmacological therapy group and 47 patients in the ozone autohemotherapy group completed the study. Compared with before therapy, the two groups showed significant improvements in VAS, MPQ, PGIC, and WHOQOL-BREF scores after therapy (P<0.05). Moreover, compared with the scores of the pharmacological therapy group, the ozone autohemotherapy group’s scores were significantly improved in the VAS, MPQ, PGIC, and WHOQOL-BREF as well as the 50% VAS reduction of the initial value after therapy (P<0.05). Finally, there were no statistically significant differences in adverse effects between groups after therapy (P>0.05).ConclusionThe results of this study demonstrated that ozone autohemotherapy combined with pharmacological therapy was superior to isolated pharmacological therapy in patients with PHN and was an effective and safe way to relieve PHN.

show abstract

“…Ozone can be administered as a gas mixture of oxygen-ozone (medical-grade ozone), with a concentration between 10 and 40 µg/mL [23][24][25][26] . However, a study on the therapy with low (10 µg/mL), medium (40 µg/mL), and high (60 µg/mL) concentrations in patients with disc herniation showed a higher rate of decline in the group who received a volume of 40 µg/ml 25.…”

Section: Types Of Administration Doses and Concentrationsmentioning

confidence: 99%

The effectiveness of percutaneous injections of ozonotherapy in low back pain

Barbosa

Sousa‐Rodrigues

Andrade

et al. 2020

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

SUMMARY INTRODUCTION Lumbar pain is one of the main reasons for medical consultation, causing the disruption of daily routines due to its disabling nature, thus resulting in social and personal damage. Among the complementary treatments, ozonotherapy offers analgesia to most patients, with reports of complications. However, great questions about its clinical effectiveness have not been answered yet, and there have been reports of serious complications. OBJECTIVE To describe the use of ozonotherapy in the treatment of lumbar pain, focusing on its favorable and unfavorable effects, and its analog profile. METHODS A cross-sectional bibliographic research was performed with scientific articles obtained from the Pubmed, LILACS and Scopus database, using the following descriptors: “Ozone”, “Therapy”, “Lumbar pain”, “complication”, “Disk herniation”, “Guideline”, “Protocol”, “Standards”, “Criteria”. RESULTS The researched literature corroborates that, in clinical practice, there is safety in the use of oxygen-ozone therapy through percutaneous injections for the treatment of lumbar pain, especially when compared to surgeries and use of medicines, provided that strict criteria are followed. CONCLUSION The procedure is effective and has a favorable analgesic profile. However, it is necessary to produce a medical guideline that will help in its strict and systematic control.

show abstract

Cardiopulmonary arrest and pneumoencephaly developing after epidural oxygen-ozone mixture therapy

Cited by 10 publications

References 14 publications

The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain

The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

The effectiveness of percutaneous injections of ozonotherapy in low back pain

Contact Info

Product

Resources

About